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Protein

BMP and activin membrane-bound inhibitor homolog

Gene

Bambi

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Negatively regulates TGF-beta signaling.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-2173788 Downregulation of TGF-beta receptor signaling

Names & Taxonomyi

Protein namesi
Recommended name:
BMP and activin membrane-bound inhibitor homolog
Alternative name(s):
Putative transmembrane protein NMA
Gene namesi
Name:Bambi
Synonyms:Nma
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1915260 Bambi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 152ExtracellularSequence analysisAdd BLAST126
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 260CytoplasmicSequence analysisAdd BLAST87

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000002078027 – 260BMP and activin membrane-bound inhibitor homologAdd BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9D0L6
PRIDEiQ9D0L6

PTM databases

PhosphoSitePlusiQ9D0L6

Expressioni

Developmental stagei

Expressed at high levels during odontogenesis.1 Publication

Gene expression databases

BgeeiENSMUSG00000024232 Expressed in 314 organ(s), highest expression level in molar tooth
GenevisibleiQ9D0L6 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9D0L6, 1 interactor
STRINGi10090.ENSMUSP00000025075

Structurei

3D structure databases

ProteinModelPortaliQ9D0L6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BAMBI family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIU1 Eukaryota
ENOG4110R2C LUCA
GeneTreeiENSGT00390000014168
HOGENOMiHOG000095174
HOVERGENiHBG050659
InParanoidiQ9D0L6
KOiK10162
OMAiVTGHENC
OrthoDBiEOG091G0PAE
PhylomeDBiQ9D0L6
TreeFamiTF333466

Family and domain databases

InterProiView protein in InterPro
IPR009345 BAMBI
PANTHERiPTHR15505:SF1 PTHR15505:SF1, 1 hit
PfamiView protein in Pfam
PF06211 BAMBI, 1 hit
PIRSFiPIRSF037456 BAMBI, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D0L6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRHSSYFFI WLQLELCAMA VLLTKGEIRC YCDAAHCVAT GYMCKSELSA
60 70 80 90 100
CFSRLLDPQN TNSPLTHGCL DSLASTADIC RAKQAQNHSG PAMPTLECCH
110 120 130 140 150
EDMCNYRGLH DVLSPSKSEA SGQGNRYQHD SSRNLITKMQ ELTSSKELWF
160 170 180 190 200
RAAVIAVPIA GGLILVLLIM LALRMLRSEN KRLQDERQQM LSRLHYSFHG
210 220 230 240 250
HHSKKGQVAK LDLECMVPVS GQENCCLTCD KMRQAELSNE KILSLVHWGM
260
YSGHGKLEFI
Length:260
Mass (Da):29,198
Last modified:June 1, 2001 - v1
Checksum:i3C27915AFA112693
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26G → E in AAK60413 (PubMed:11706948).Curated1
Sequence conflicti116 – 118SKS → PRG in AAK60413 (PubMed:11706948).Curated3
Sequence conflicti138K → N in AAK60413 (PubMed:11706948).Curated1
Sequence conflicti180N → I in AAK60413 (PubMed:11706948).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153440 mRNA Translation: AAK60413.1
AK011305 mRNA Translation: BAB27531.1
AK045192 mRNA Translation: BAC32256.1
AK164632 mRNA Translation: BAE37852.1
BC019378 mRNA Translation: AAH19378.1
CCDSiCCDS29034.1
RefSeqiNP_080781.1, NM_026505.2
UniGeneiMm.284863

Genome annotation databases

EnsembliENSMUST00000025075; ENSMUSP00000025075; ENSMUSG00000024232
GeneIDi68010
KEGGimmu:68010
UCSCiuc008dyc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153440 mRNA Translation: AAK60413.1
AK011305 mRNA Translation: BAB27531.1
AK045192 mRNA Translation: BAC32256.1
AK164632 mRNA Translation: BAE37852.1
BC019378 mRNA Translation: AAH19378.1
CCDSiCCDS29034.1
RefSeqiNP_080781.1, NM_026505.2
UniGeneiMm.284863

3D structure databases

ProteinModelPortaliQ9D0L6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D0L6, 1 interactor
STRINGi10090.ENSMUSP00000025075

PTM databases

PhosphoSitePlusiQ9D0L6

Proteomic databases

PaxDbiQ9D0L6
PRIDEiQ9D0L6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025075; ENSMUSP00000025075; ENSMUSG00000024232
GeneIDi68010
KEGGimmu:68010
UCSCiuc008dyc.1 mouse

Organism-specific databases

CTDi25805
MGIiMGI:1915260 Bambi

Phylogenomic databases

eggNOGiENOG410IIU1 Eukaryota
ENOG4110R2C LUCA
GeneTreeiENSGT00390000014168
HOGENOMiHOG000095174
HOVERGENiHBG050659
InParanoidiQ9D0L6
KOiK10162
OMAiVTGHENC
OrthoDBiEOG091G0PAE
PhylomeDBiQ9D0L6
TreeFamiTF333466

Enzyme and pathway databases

ReactomeiR-MMU-2173788 Downregulation of TGF-beta receptor signaling

Miscellaneous databases

ChiTaRSiBambi mouse
PROiPR:Q9D0L6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024232 Expressed in 314 organ(s), highest expression level in molar tooth
GenevisibleiQ9D0L6 MM

Family and domain databases

InterProiView protein in InterPro
IPR009345 BAMBI
PANTHERiPTHR15505:SF1 PTHR15505:SF1, 1 hit
PfamiView protein in Pfam
PF06211 BAMBI, 1 hit
PIRSFiPIRSF037456 BAMBI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBAMBI_MOUSE
AccessioniPrimary (citable) accession number: Q9D0L6
Secondary accession number(s): Q3TP85, Q91XS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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