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Protein

Zinc finger BED domain-containing protein 3

Gene

Zbed3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri33 – 95BED-typeAdd BLAST63

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger BED domain-containing protein 3
Alternative name(s):
Axin-interacting protein
Gene namesi
Name:Zbed3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1919364 Zbed3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi111S → A: Decreases the interaction with AXIN1, GSK3B-mediated beta-catenin phosphorylation, cytoplasmic beta-catenin accumulation and Wnt-mediated transcription activation. 1 Publication1
Mutagenesisi113T → A: Decreases the interaction with AXIN1, GSK3B-mediated beta-catenin phosphorylation, cytoplasmic beta-catenin accumulation and Wnt-mediated transcription activation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004212571 – 228Zinc finger BED domain-containing protein 3Add BLAST228

Post-translational modificationi

Dual phosphorylation on serine and tyrosine residues of the cytoplasmic PPPSP motif by GSK3 and CK1 may be required for AXIN1-binding.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9D0L1
PaxDbiQ9D0L1
PRIDEiQ9D0L1

2D gel databases

REPRODUCTION-2DPAGEiQ9D0L1

PTM databases

iPTMnetiQ9D0L1
PhosphoSitePlusiQ9D0L1

Expressioni

Gene expression databases

BgeeiENSMUSG00000041995 Expressed in 220 organ(s), highest expression level in oocyte
ExpressionAtlasiQ9D0L1 baseline and differential
GenevisibleiQ9D0L1 MM

Interactioni

Subunit structurei

Interacts (via PPPSP motif) with AXIN1; the interaction is direct, enhanced by protein kinase GSK3B and casein kinase CSNK1E activities and decreases GSK3B-induced beta-catenin serine and threonine phosphorylations.1 Publication

Protein-protein interaction databases

BioGridi215161, 2 interactors
IntActiQ9D0L1, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9D0L1
SMRiQ9D0L1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili132 – 185Sequence analysisAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi103 – 113PPPSP motifAdd BLAST11

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri33 – 95BED-typeAdd BLAST63

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IXJY Eukaryota
ENOG41115R7 LUCA
GeneTreeiENSGT00390000013530
HOVERGENiHBG063677
InParanoidiQ9D0L1
OMAiDGCVITK
OrthoDBiEOG091G0JGE
PhylomeDBiQ9D0L1
TreeFamiTF338048

Family and domain databases

InterProiView protein in InterPro
IPR033546 ZBED3
IPR003656 Znf_BED
IPR036236 Znf_C2H2_sf
PANTHERiPTHR35827:SF2 PTHR35827:SF2, 1 hit
SMARTiView protein in SMART
SM00614 ZnF_BED, 1 hit
SUPFAMiSSF57667 SSF57667, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D0L1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSKKPLKIT MEDSRRLNDP AEQGGLCPAP VGPSYSEAWG YFHLDPAQPR
60 70 80 90 100
HRMMSAWATC RLCGLQVGGL PNFQMWTRAL CQHLSDVHLP ELKKSAAPSS
110 120 130 140 150
PTTMPCPPPP SPTMAAEGDW ARLLEQMGEL AMRGSQRELE LERREAALMQ
160 170 180 190 200
AELELERKRQ ALKQEAQSVE QERHQLQVER EALSKWIKKQ SPGAQVPEPP
210 220
SPLPLLPKED PDIHDNNSDN DMVTKVLL
Length:228
Mass (Da):25,609
Last modified:June 1, 2001 - v1
Checksum:i1CB44DD084B895A3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VIM9A0A1Y7VIM9_MOUSE
Zinc finger BED domain-containing p...
Zbed3
152Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011319 mRNA Translation: BAB27542.1
AK135692 mRNA Translation: BAE22613.1
AK135797 mRNA Translation: BAE22666.1
AK162256 mRNA Translation: BAE36818.1
AK163367 mRNA Translation: BAE37318.1
AC133188 Genomic DNA No translation available.
CH466567 Genomic DNA Translation: EDL00907.1
CH466567 Genomic DNA Translation: EDL00908.1
CH466567 Genomic DNA Translation: EDL00909.1
BC016263 mRNA Translation: AAH16263.1
BC085478 mRNA Translation: AAH85478.1
CCDSiCCDS26696.1
RefSeqiNP_001289467.1, NM_001302538.1
NP_001289468.1, NM_001302539.1
NP_082382.1, NM_028106.3
UniGeneiMm.3774

Genome annotation databases

EnsembliENSMUST00000045909; ENSMUSP00000044774; ENSMUSG00000041995
ENSMUST00000221807; ENSMUSP00000152153; ENSMUSG00000041995
GeneIDi72114
KEGGimmu:72114
UCSCiuc007rmg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011319 mRNA Translation: BAB27542.1
AK135692 mRNA Translation: BAE22613.1
AK135797 mRNA Translation: BAE22666.1
AK162256 mRNA Translation: BAE36818.1
AK163367 mRNA Translation: BAE37318.1
AC133188 Genomic DNA No translation available.
CH466567 Genomic DNA Translation: EDL00907.1
CH466567 Genomic DNA Translation: EDL00908.1
CH466567 Genomic DNA Translation: EDL00909.1
BC016263 mRNA Translation: AAH16263.1
BC085478 mRNA Translation: AAH85478.1
CCDSiCCDS26696.1
RefSeqiNP_001289467.1, NM_001302538.1
NP_001289468.1, NM_001302539.1
NP_082382.1, NM_028106.3
UniGeneiMm.3774

3D structure databases

ProteinModelPortaliQ9D0L1
SMRiQ9D0L1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215161, 2 interactors
IntActiQ9D0L1, 2 interactors

PTM databases

iPTMnetiQ9D0L1
PhosphoSitePlusiQ9D0L1

2D gel databases

REPRODUCTION-2DPAGEiQ9D0L1

Proteomic databases

MaxQBiQ9D0L1
PaxDbiQ9D0L1
PRIDEiQ9D0L1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045909; ENSMUSP00000044774; ENSMUSG00000041995
ENSMUST00000221807; ENSMUSP00000152153; ENSMUSG00000041995
GeneIDi72114
KEGGimmu:72114
UCSCiuc007rmg.2 mouse

Organism-specific databases

CTDi84327
MGIiMGI:1919364 Zbed3

Phylogenomic databases

eggNOGiENOG410IXJY Eukaryota
ENOG41115R7 LUCA
GeneTreeiENSGT00390000013530
HOVERGENiHBG063677
InParanoidiQ9D0L1
OMAiDGCVITK
OrthoDBiEOG091G0JGE
PhylomeDBiQ9D0L1
TreeFamiTF338048

Miscellaneous databases

ChiTaRSiZbed3 mouse
PROiPR:Q9D0L1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041995 Expressed in 220 organ(s), highest expression level in oocyte
ExpressionAtlasiQ9D0L1 baseline and differential
GenevisibleiQ9D0L1 MM

Family and domain databases

InterProiView protein in InterPro
IPR033546 ZBED3
IPR003656 Znf_BED
IPR036236 Znf_C2H2_sf
PANTHERiPTHR35827:SF2 PTHR35827:SF2, 1 hit
SMARTiView protein in SMART
SM00614 ZnF_BED, 1 hit
SUPFAMiSSF57667 SSF57667, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZBED3_MOUSE
AccessioniPrimary (citable) accession number: Q9D0L1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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