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Protein

Peroxisomal membrane protein PEX13

Gene

Pex13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins (By similarity).By similarity

GO - Molecular functioni

  • peroxisome targeting sequence binding Source: MGI

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-MMU-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PEX13
Alternative name(s):
Peroxin-13
Gene namesi
Name:Pex13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919379 Pex13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 235LumenalSequence analysisAdd BLAST235
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 405CytoplasmicSequence analysisAdd BLAST149

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002406621 – 405Peroxisomal membrane protein PEX13Add BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei356PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D0K1
MaxQBiQ9D0K1
PaxDbiQ9D0K1
PeptideAtlasiQ9D0K1
PRIDEiQ9D0K1

PTM databases

iPTMnetiQ9D0K1
PhosphoSitePlusiQ9D0K1

Expressioni

Gene expression databases

BgeeiENSMUSG00000020283 Expressed in 288 organ(s), highest expression level in secondary oocyte
CleanExiMM_PEX13
ExpressionAtlasiQ9D0K1 baseline and differential
GenevisibleiQ9D0K1 MM

Interactioni

Subunit structurei

Interacts with PEX19.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020523

Structurei

Secondary structure

1405
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9D0K1
SMRiQ9D0K1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9D0K1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini274 – 338SH3PROSITE-ProRule annotationAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 61Pro-richAdd BLAST57

Sequence similaritiesi

Belongs to the peroxin-13 family.Curated

Keywords - Domaini

SH3 domain, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3875 Eukaryota
ENOG410XRU7 LUCA
GeneTreeiENSGT00390000016883
HOGENOMiHOG000231374
HOVERGENiHBG053570
InParanoidiQ9D0K1
KOiK13344
OMAiDSTFFAL
OrthoDBiEOG091G0LMX
PhylomeDBiQ9D0K1
TreeFamiTF327117

Family and domain databases

InterProiView protein in InterPro
IPR007223 Peroxin-13_N
IPR035463 Pex13
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR19332 PTHR19332, 1 hit
PfamiView protein in Pfam
PF04088 Peroxin-13_N, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D0K1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASQPPPPPK PWESRRIPGA GPGPGSGPGP TYQSADLGPT LLTRPGQPTL
60 70 80 90 100
TRVPPPILPR PSQQTGSNNV NTFRPAYSSF SSGYGAYGNS FYGSYSPYSY
110 120 130 140 150
GYNGLGFNRL RVDDLPPSRF VQQAEESSRG AFQSIESIVH AFASVSMMMD
160 170 180 190 200
ATFSAVYNSF RAVLDVANHF SRLKIHFTKV FSAFALVRTI RYLYRRLQWM
210 220 230 240 250
MGLRRGSENE DLWAESEGTV ACLSAEDQAT NSAKSWPIFL FFAVILGGPY
260 270 280 290 300
LIWKLLSTHN DEVTDNTNWA SGEDDHVVAR AEYDFVAVSD EEISFRAGDM
310 320 330 340 350
LNLALKEQQP KVRGWLLASL DGQTTGLIPA NYVKILGKRR GRKTIESSTM
360 370 380 390 400
LKQQQSFTNP TLIKGVTTTN PLDEQEAAFE SVFVETNKVS SAPDSTGKNG

DKQDL
Length:405
Mass (Da):44,610
Last modified:June 1, 2001 - v1
Checksum:i4ABF0463211AA466
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RH41D6RH41_MOUSE
Peroxisomal membrane protein PEX13
Pex13
40Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177F → C in CAC20705 (Ref. 2) Curated1
Sequence conflicti200M → K in BAC27635 (PubMed:16141072).Curated1
Sequence conflicti203L → I in CAC20705 (Ref. 2) Curated1
Sequence conflicti206G → S in CAC20705 (Ref. 2) Curated1
Sequence conflicti227D → N in BAE31995 (PubMed:16141072).Curated1
Sequence conflicti239 – 241FLF → ILS in CAC20705 (Ref. 2) Curated3
Sequence conflicti291E → G in BAE31995 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329877 mRNA Translation: AAK15313.2
AJ304506 mRNA Translation: CAC20705.1
AK011355 mRNA Translation: BAB27563.1
AK029099 mRNA Translation: BAC26296.1
AK029336 mRNA Translation: BAC26402.1
AK031710 mRNA Translation: BAC27526.1
AK031975 mRNA Translation: BAC27635.1
AK032650 mRNA Translation: BAC27971.1
AK153438 mRNA Translation: BAE31995.1
AK169148 mRNA Translation: BAE40927.1
BC023683 mRNA Translation: AAH23683.1
CCDSiCCDS24478.1
RefSeqiNP_076140.2, NM_023651.4
UniGeneiMm.286622
Mm.29536

Genome annotation databases

EnsembliENSMUST00000020523; ENSMUSP00000020523; ENSMUSG00000020283
GeneIDi72129
KEGGimmu:72129
UCSCiuc007ifj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329877 mRNA Translation: AAK15313.2
AJ304506 mRNA Translation: CAC20705.1
AK011355 mRNA Translation: BAB27563.1
AK029099 mRNA Translation: BAC26296.1
AK029336 mRNA Translation: BAC26402.1
AK031710 mRNA Translation: BAC27526.1
AK031975 mRNA Translation: BAC27635.1
AK032650 mRNA Translation: BAC27971.1
AK153438 mRNA Translation: BAE31995.1
AK169148 mRNA Translation: BAE40927.1
BC023683 mRNA Translation: AAH23683.1
CCDSiCCDS24478.1
RefSeqiNP_076140.2, NM_023651.4
UniGeneiMm.286622
Mm.29536

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WXUNMR-A267-346[»]
ProteinModelPortaliQ9D0K1
SMRiQ9D0K1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020523

PTM databases

iPTMnetiQ9D0K1
PhosphoSitePlusiQ9D0K1

Proteomic databases

EPDiQ9D0K1
MaxQBiQ9D0K1
PaxDbiQ9D0K1
PeptideAtlasiQ9D0K1
PRIDEiQ9D0K1

Protocols and materials databases

DNASUi72129
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020523; ENSMUSP00000020523; ENSMUSG00000020283
GeneIDi72129
KEGGimmu:72129
UCSCiuc007ifj.1 mouse

Organism-specific databases

CTDi5194
MGIiMGI:1919379 Pex13

Phylogenomic databases

eggNOGiKOG3875 Eukaryota
ENOG410XRU7 LUCA
GeneTreeiENSGT00390000016883
HOGENOMiHOG000231374
HOVERGENiHBG053570
InParanoidiQ9D0K1
KOiK13344
OMAiDSTFFAL
OrthoDBiEOG091G0LMX
PhylomeDBiQ9D0K1
TreeFamiTF327117

Enzyme and pathway databases

ReactomeiR-MMU-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-MMU-9033241 Peroxisomal protein import

Miscellaneous databases

ChiTaRSiPex13 mouse
EvolutionaryTraceiQ9D0K1
PROiPR:Q9D0K1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020283 Expressed in 288 organ(s), highest expression level in secondary oocyte
CleanExiMM_PEX13
ExpressionAtlasiQ9D0K1 baseline and differential
GenevisibleiQ9D0K1 MM

Family and domain databases

InterProiView protein in InterPro
IPR007223 Peroxin-13_N
IPR035463 Pex13
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR19332 PTHR19332, 1 hit
PfamiView protein in Pfam
PF04088 Peroxin-13_N, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPEX13_MOUSE
AccessioniPrimary (citable) accession number: Q9D0K1
Secondary accession number(s): Q3U5T1
, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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