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Protein

General transcription factor IIE subunit 1

Gene

Gtf2e1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri129 – 157C4-typeSequence analysisAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIE subunit 1
Alternative name(s):
General transcription factor IIE 56 kDa subunit
Transcription initiation factor IIE subunit alpha
Short name:
TFIIE-alpha
Gene namesi
Name:Gtf2e1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1921447 Gtf2e1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002112232 – 440General transcription factor IIE subunit 1Add BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei67N6-acetyllysineBy similarity1
Modified residuei268PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D0D5
MaxQBiQ9D0D5
PaxDbiQ9D0D5
PeptideAtlasiQ9D0D5
PRIDEiQ9D0D5

PTM databases

iPTMnetiQ9D0D5
PhosphoSitePlusiQ9D0D5

Expressioni

Gene expression databases

BgeeiENSMUSG00000022828 Expressed in 267 organ(s), highest expression level in pes
GenevisibleiQ9D0D5 MM

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains. Interacts with TAF6/TAFII80. Interacts with ATF7IP. Interacts with SND1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi216568, 13 interactors
IntActiQ9D0D5, 1 interactor
MINTiQ9D0D5
STRINGi10090.ENSMUSP00000023525

Structurei

3D structure databases

ProteinModelPortaliQ9D0D5
SMRiQ9D0D5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 104HTH TFE/IIEalpha-typePROSITE-ProRule annotationAdd BLAST91

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi380 – 394Asp/Glu-rich (acidic)Add BLAST15

Sequence similaritiesi

Belongs to the TFIIE alpha subunit family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri129 – 157C4-typeSequence analysisAdd BLAST29

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2593 Eukaryota
COG1675 LUCA
GeneTreeiENSGT00390000016696
HOGENOMiHOG000007666
HOVERGENiHBG008614
InParanoidiQ9D0D5
KOiK03136
OMAiYQEYYSH
OrthoDBiEOG091G0D8N
PhylomeDBiQ9D0D5
TreeFamiTF313429

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR039997 TFE
IPR017919 TFIIE/TFIIEa_HTH
IPR002853 TFIIE_asu
IPR021600 TFIIE_asu_C
IPR024550 TFIIEa/SarR/Rpc3_HTH_dom
IPR013083 Znf_RING/FYVE/PHD
IPR013137 Znf_TFIIB
PANTHERiPTHR13097 PTHR13097, 1 hit
PfamiView protein in Pfam
PF08271 TF_Zn_Ribbon, 1 hit
PF11521 TFIIE-A_C, 1 hit
PF02002 TFIIE_alpha, 1 hit
SMARTiView protein in SMART
SM00531 TFIIE, 1 hit
PROSITEiView protein in PROSITE
PS51344 HTH_TFE_IIE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D0D5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADPDVLTEV PAALKRLAKY VIRGFYGIEH VLALDILIRN PCVKEEDMLE
60 70 80 90 100
LLKFDRKQLR SVLNNLKGDK FIKCRMRVET AADGKTTRHN YYFINYRTLV
110 120 130 140 150
NVVKYKLDHM RRRIETDERN STNRASFKCP VCCSTFTDLE ANQLFDPMTG
160 170 180 190 200
TFRCTFCHTE VEEDESAMPK KDARTLLARF NEQIEPIYAL LRETEDVNLA
210 220 230 240 250
YEILEPEPTE IPALKQSKDR AATAAGAAGL AGGHHREAWT NKGPSYEDLY
260 270 280 290 300
TQNVVINMDD QDDVHRPSLE GKAAKERPIW LRESTVQGAY SSEEMKEGGI
310 320 330 340 350
DVDTFQEREE ARAGPDDNEE VMRALLIHEK KTSSVTAGSV GAAAPVTAAN
360 370 380 390 400
GSDSESETSE SDDDSPPRPA AAAPPHHHRD EDEEDEEFEE VADDPIVMVA
410 420 430 440
GCPFSYSEVS QRPELVAQMT PEEKEAYIAM GQRMFEDLFE
Length:440
Mass (Da):49,593
Last modified:June 1, 2001 - v1
Checksum:i0587E4DFE6FA0442
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011543 mRNA Translation: BAB27686.1
AK031528 mRNA Translation: BAC27436.1
AK154283 mRNA Translation: BAE32487.1
BC056966 mRNA Translation: AAH56966.1
CCDSiCCDS28160.1
RefSeqiNP_083088.1, NM_028812.3
XP_006522722.1, XM_006522659.3
UniGeneiMm.287795

Genome annotation databases

EnsembliENSMUST00000023525; ENSMUSP00000023525; ENSMUSG00000022828
GeneIDi74197
KEGGimmu:74197
UCSCiuc007zeb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011543 mRNA Translation: BAB27686.1
AK031528 mRNA Translation: BAC27436.1
AK154283 mRNA Translation: BAE32487.1
BC056966 mRNA Translation: AAH56966.1
CCDSiCCDS28160.1
RefSeqiNP_083088.1, NM_028812.3
XP_006522722.1, XM_006522659.3
UniGeneiMm.287795

3D structure databases

ProteinModelPortaliQ9D0D5
SMRiQ9D0D5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216568, 13 interactors
IntActiQ9D0D5, 1 interactor
MINTiQ9D0D5
STRINGi10090.ENSMUSP00000023525

PTM databases

iPTMnetiQ9D0D5
PhosphoSitePlusiQ9D0D5

Proteomic databases

EPDiQ9D0D5
MaxQBiQ9D0D5
PaxDbiQ9D0D5
PeptideAtlasiQ9D0D5
PRIDEiQ9D0D5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023525; ENSMUSP00000023525; ENSMUSG00000022828
GeneIDi74197
KEGGimmu:74197
UCSCiuc007zeb.1 mouse

Organism-specific databases

CTDi2960
MGIiMGI:1921447 Gtf2e1

Phylogenomic databases

eggNOGiKOG2593 Eukaryota
COG1675 LUCA
GeneTreeiENSGT00390000016696
HOGENOMiHOG000007666
HOVERGENiHBG008614
InParanoidiQ9D0D5
KOiK03136
OMAiYQEYYSH
OrthoDBiEOG091G0D8N
PhylomeDBiQ9D0D5
TreeFamiTF313429

Enzyme and pathway databases

ReactomeiR-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Miscellaneous databases

PROiPR:Q9D0D5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022828 Expressed in 267 organ(s), highest expression level in pes
GenevisibleiQ9D0D5 MM

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR039997 TFE
IPR017919 TFIIE/TFIIEa_HTH
IPR002853 TFIIE_asu
IPR021600 TFIIE_asu_C
IPR024550 TFIIEa/SarR/Rpc3_HTH_dom
IPR013083 Znf_RING/FYVE/PHD
IPR013137 Znf_TFIIB
PANTHERiPTHR13097 PTHR13097, 1 hit
PfamiView protein in Pfam
PF08271 TF_Zn_Ribbon, 1 hit
PF11521 TFIIE-A_C, 1 hit
PF02002 TFIIE_alpha, 1 hit
SMARTiView protein in SMART
SM00531 TFIIE, 1 hit
PROSITEiView protein in PROSITE
PS51344 HTH_TFE_IIE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT2EA_MOUSE
AccessioniPrimary (citable) accession number: Q9D0D5
Secondary accession number(s): Q544T0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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