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UniProtKB - Q9D0B1 (ZN524_MOUSE)
Protein
Zinc finger protein 524
Gene
Znf524
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 49 – 59 | A.T hookAdd BLAST | 11 | |
Zinc fingeri | 109 – 131 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 137 – 159 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 165 – 187 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 193 – 216 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 524 |
Gene namesi | Name:Znf524 Synonyms:Zfp524 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1916740, Zfp524 |
VEuPathDBi | HostDB:ENSMUSG00000051184 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000234580 | 1 – 321 | Zinc finger protein 524Add BLAST | 321 |
Proteomic databases
EPDi | Q9D0B1 |
MaxQBi | Q9D0B1 |
PaxDbi | Q9D0B1 |
PRIDEi | Q9D0B1 |
ProteomicsDBi | 299585 |
PTM databases
PhosphoSitePlusi | Q9D0B1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000051184, Expressed in head and 195 other tissues |
Genevisiblei | Q9D0B1, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 211183, 1 interactor |
IntActi | Q9D0B1, 1 interactor |
STRINGi | 10090.ENSMUSP00000083533 |
Miscellaneous databases
RNActi | Q9D0B1, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 80 | DisorderedSequence analysisAdd BLAST | 80 | |
Regioni | 86 – 105 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 248 – 321 | DisorderedSequence analysisAdd BLAST | 74 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 259 – 274 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 109 – 131 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 137 – 159 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 165 – 187 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 193 – 216 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163198 |
HOGENOMi | CLU_1057530_0_0_1 |
InParanoidi | Q9D0B1 |
OMAi | PKRAPHF |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9D0B1 |
TreeFami | TF338348 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
i Sequence
Sequence statusi: Complete.
Q9D0B1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDNPSSDPLP STLSGEEEKP LALLPPVPRG RRGRPPGGAT TSNRTLKSSL
60 70 80 90 100
PRKRGRPPRS EQETPLTAPV DSGGSSDLLL IDDQGVPYTV PEGSAADGPQ
110 120 130 140 150
GSGSKRAPHF CPVCLRAFPY LSDLERHSIS HSELKPHVCK DCGKTFKRSS
160 170 180 190 200
HLRRHCNIHA GLRPFRCVLC PRRFREAGEL AHHHRIHSGE RPYQCPSCRV
210 220 230 240 250
RFTEANTLRR HYKRKHPELV GMPVRLCPPN PRTQPLWDDD EGIPVQEGVQ
260 270 280 290 300
EESPEGKEPT WPISSTTSPL SGFTAGGSAG AGRGQEGQDT LVSGGIPTME
310 320
GDQKQGPKPL GPGAIGHPPV D
Sequence cautioni
The sequence BAB22215 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 255 | E → G in BAB22215 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002594 mRNA Translation: BAB22215.1 Frameshift. AK011620 mRNA Translation: BAB27739.1 AK154328 mRNA Translation: BAE32517.1 BC019995 mRNA Translation: AAH19995.1 |
CCDSi | CCDS20752.1 |
RefSeqi | NP_079600.1, NM_025324.2 XP_006540339.1, XM_006540276.2 XP_006540340.1, XM_006540277.3 XP_011248972.1, XM_011250670.1 |
Genome annotation databases
Ensembli | ENSMUST00000086349; ENSMUSP00000083533; ENSMUSG00000051184 ENSMUST00000207901; ENSMUSP00000146921; ENSMUSG00000051184 ENSMUST00000209030; ENSMUSP00000147095; ENSMUSG00000051184 |
GeneIDi | 66056 |
KEGGi | mmu:66056 |
UCSCi | uc009ezj.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002594 mRNA Translation: BAB22215.1 Frameshift. AK011620 mRNA Translation: BAB27739.1 AK154328 mRNA Translation: BAE32517.1 BC019995 mRNA Translation: AAH19995.1 |
CCDSi | CCDS20752.1 |
RefSeqi | NP_079600.1, NM_025324.2 XP_006540339.1, XM_006540276.2 XP_006540340.1, XM_006540277.3 XP_011248972.1, XM_011250670.1 |
3D structure databases
SMRi | Q9D0B1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 211183, 1 interactor |
IntActi | Q9D0B1, 1 interactor |
STRINGi | 10090.ENSMUSP00000083533 |
PTM databases
PhosphoSitePlusi | Q9D0B1 |
Proteomic databases
EPDi | Q9D0B1 |
MaxQBi | Q9D0B1 |
PaxDbi | Q9D0B1 |
PRIDEi | Q9D0B1 |
ProteomicsDBi | 299585 |
Protocols and materials databases
DNASUi | 66056 |
Genome annotation databases
Ensembli | ENSMUST00000086349; ENSMUSP00000083533; ENSMUSG00000051184 ENSMUST00000207901; ENSMUSP00000146921; ENSMUSG00000051184 ENSMUST00000209030; ENSMUSP00000147095; ENSMUSG00000051184 |
GeneIDi | 66056 |
KEGGi | mmu:66056 |
UCSCi | uc009ezj.1, mouse |
Organism-specific databases
CTDi | 66056 |
MGIi | MGI:1916740, Zfp524 |
VEuPathDBi | HostDB:ENSMUSG00000051184 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163198 |
HOGENOMi | CLU_1057530_0_0_1 |
InParanoidi | Q9D0B1 |
OMAi | PKRAPHF |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9D0B1 |
TreeFami | TF338348 |
Miscellaneous databases
BioGRID-ORCSi | 66056, 0 hits in 62 CRISPR screens |
PROi | PR:Q9D0B1 |
RNActi | Q9D0B1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000051184, Expressed in head and 195 other tissues |
Genevisiblei | Q9D0B1, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN524_MOUSE | |
Accessioni | Q9D0B1Primary (citable) accession number: Q9D0B1 Secondary accession number(s): Q9DCQ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2006 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families