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Protein

Arpin

Gene

Arpin

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Arpin
Alternative name(s):
Arp2/3 inhibition protein
Gene namesi
Name:Arpin
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1917670 Arpin

Subcellular locationi

Keywords - Cellular componenti

Cell projection

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002442661 – 226ArpinAdd BLAST226

Proteomic databases

MaxQBiQ9D0A3
PaxDbiQ9D0A3
PeptideAtlasiQ9D0A3
PRIDEiQ9D0A3

PTM databases

iPTMnetiQ9D0A3
PhosphoSitePlusiQ9D0A3

Expressioni

Gene expression databases

BgeeiENSMUSG00000039043 Expressed in 226 organ(s), highest expression level in intestine
CleanExiMM_2610034B18RIK
GenevisibleiQ9D0A3 MM

Interactioni

Subunit structurei

Associates with the Arp2/3 complex. Interacts with ARPC2; enhanced by activated RAC1. Interacts with ARPC5; the interaction is dependent on RAC1.1 Publication

Protein-protein interaction databases

DIPiDIP-60588N
IntActiQ9D0A3, 2 interactors
MINTiQ9D0A3
STRINGi10090.ENSMUSP00000049440

Structurei

3D structure databases

ProteinModelPortaliQ9D0A3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni211 – 226Necessary and sufficient fopr interaction with ARPC2By similarityAdd BLAST16

Domaini

The acidic C-terminus is necessary and sufficient to inhibit ARP2/3 complex activity.By similarity

Sequence similaritiesi

Belongs to the Arpin family.Curated

Phylogenomic databases

eggNOGiENOG410IGMB Eukaryota
ENOG4111JJD LUCA
GeneTreeiENSGT00530000064251
HOGENOMiHOG000111854
HOVERGENiHBG054275
InParanoidiQ9D0A3
OMAiWAFWYPE
OrthoDBiEOG091G0QZV
PhylomeDBiQ9D0A3

Family and domain databases

InterProiView protein in InterPro
IPR018889 Arpin
PANTHERiPTHR31199 PTHR31199, 1 hit
PfamiView protein in Pfam
PF10574 UPF0552, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D0A3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRIYQDSAL RNKAVQSARL PGTWDPATHQ GGNGILLEGE LVDVSRHSIL
60 70 80 90 100
DAHGRKERYY VLYIQPSCIH RRKFDPKGNE IEPNFSATRK VNTGFLMSSY
110 120 130 140 150
KVEAKGDTDR LTLEALKSLV NKPQLLELTE SLTPDQAVAF WMPESEMEVM
160 170 180 190 200
ELELGTGVRL KTRGDGPFID SLAKLELGTV TKCNFAGDGK TGASWTDNIM
210 220
AQKSSERNTA EIREQGDGAE DEEWDD
Length:226
Mass (Da):25,193
Last modified:June 1, 2001 - v1
Checksum:i31D7F805E7581345
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49I → V in BAE33545 (PubMed:16141072).Curated1
Sequence conflicti85F → L in BAC30326 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011654 mRNA Translation: BAB27760.1
AK039350 mRNA Translation: BAC30326.1
AK051261 mRNA Translation: BAC34579.1
AK156013 mRNA Translation: BAE33545.1
BC031379 mRNA Translation: AAH31379.1
CCDSiCCDS21390.1
RefSeqiNP_081696.1, NM_027420.4
UniGeneiMm.34266

Genome annotation databases

EnsembliENSMUST00000048731; ENSMUSP00000049440; ENSMUSG00000039043
GeneIDi70420
KEGGimmu:70420
UCSCiuc009hzh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011654 mRNA Translation: BAB27760.1
AK039350 mRNA Translation: BAC30326.1
AK051261 mRNA Translation: BAC34579.1
AK156013 mRNA Translation: BAE33545.1
BC031379 mRNA Translation: AAH31379.1
CCDSiCCDS21390.1
RefSeqiNP_081696.1, NM_027420.4
UniGeneiMm.34266

3D structure databases

ProteinModelPortaliQ9D0A3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60588N
IntActiQ9D0A3, 2 interactors
MINTiQ9D0A3
STRINGi10090.ENSMUSP00000049440

PTM databases

iPTMnetiQ9D0A3
PhosphoSitePlusiQ9D0A3

Proteomic databases

MaxQBiQ9D0A3
PaxDbiQ9D0A3
PeptideAtlasiQ9D0A3
PRIDEiQ9D0A3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048731; ENSMUSP00000049440; ENSMUSG00000039043
GeneIDi70420
KEGGimmu:70420
UCSCiuc009hzh.1 mouse

Organism-specific databases

CTDi348110
MGIiMGI:1917670 Arpin

Phylogenomic databases

eggNOGiENOG410IGMB Eukaryota
ENOG4111JJD LUCA
GeneTreeiENSGT00530000064251
HOGENOMiHOG000111854
HOVERGENiHBG054275
InParanoidiQ9D0A3
OMAiWAFWYPE
OrthoDBiEOG091G0QZV
PhylomeDBiQ9D0A3

Miscellaneous databases

PROiPR:Q9D0A3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039043 Expressed in 226 organ(s), highest expression level in intestine
CleanExiMM_2610034B18RIK
GenevisibleiQ9D0A3 MM

Family and domain databases

InterProiView protein in InterPro
IPR018889 Arpin
PANTHERiPTHR31199 PTHR31199, 1 hit
PfamiView protein in Pfam
PF10574 UPF0552, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARPIN_MOUSE
AccessioniPrimary (citable) accession number: Q9D0A3
Secondary accession number(s): Q3U1F3, Q8CA84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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