Alg14

Functionⁱ

Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER (By similarity).By similarity

GO - Biological processⁱ

dolichol-linked oligosaccharide biosynthetic process Source: InterPro

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

Reactomeⁱ

R-MMU-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GT1 Glycosyltransferase Family 1

CAZyⁱ

GT1 Glycosyltransferase Family 1

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: UDP-N-acetylglucosamine transferase subunit ALG14 homolog
Gene namesⁱ	Name:Alg14
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:1914039 Alg14

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 3	LumenalBy similarity	3
Transmembraneⁱ	4 – 26	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	27 – 217	CytoplasmicBy similarityAdd BLAST	191

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000265117	1 – 217	UDP-N-acetylglucosamine transferase subunit ALG14 homologAdd BLAST		217

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9D081
PaxDbⁱ	Q9D081
PeptideAtlas More...PeptideAtlasⁱ	Q9D081
PRIDEⁱ	Q9D081

PTM databases

iPTMnetⁱ	Q9D081
PhosphoSitePlusⁱ	Q9D081

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000039887
ExpressionAtlasⁱ	Q9D081 baseline and differential
Genevisibleⁱ	Q9D081 MM

Interactionⁱ

Subunit structureⁱ

Heterodimer with ALG13 to form a functional enzyme.By similarity

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000038387

STRINGⁱ

10090.ENSMUSP00000038387

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9D081
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ALG14 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3339 Eukaryota ENOG4111QSM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002579
HOGENOMⁱ	HOG000182099
HOVERGENⁱ	HBG059605
InParanoidⁱ	Q9D081
KEGG Orthology (KO) More...KOⁱ	K07441
OMAⁱ	ESICRVK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0K4A
PhylomeDBⁱ	Q9D081
TreeFamⁱ	TF105628

Family and domain databases

InterProⁱ	View protein in InterPro IPR013969 Oligosacch_biosynth_Alg14
PANTHERⁱ	PTHR12154 PTHR12154, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08660 Alg14, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9D081-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLSILILAAT AAGLVILLFQ RLWTVLGPHH VTPRESLRLL IVAGSGGHTT 
        60         70         80         90        100
EILRLVGSLS NAYSPRHYVI AESDEMSAKK IHSLEELSRA QNDSTTEYPK 
       110        120        130        140        150
YHLHRIPRSR EVRQSWLSSV FTTFYSMWFS FPLVLRIKPD LVLCNGPGTC 
       160        170        180        190        200
VPICVSALLL GILGVKKVII VYVESICRVE TLSLSGKILR HLSDYFIVQW 
       210 
PTLKEKYPKS VYLGRIV

Length:217

Mass (Da):24,429

Last modified:June 1, 2001 - v1

Checksum:ⁱ471268EC8AF6BF15

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK011733 mRNA Translation: BAB27807.1 AK017354 mRNA Translation: BAC25513.1 BC002278 mRNA Translation: AAH02278.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17801.1
NCBI Reference Sequences More...RefSeqⁱ	NP_077140.1, NM_024178.2
UniGeneⁱ	Mm.269881

Genome annotation databases

Ensemblⁱ	ENSMUST00000039442; ENSMUSP00000038387; ENSMUSG00000039887
GeneIDⁱ	66789
KEGGⁱ	mmu:66789
UCSC genome browser More...UCSCⁱ	uc008rdx.1 mouse

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length
Q9D081	UPI0003D72CAB		MOUSE		222
UPI000A30857C		MUSPA		217
UPI000A316F6C		MUSCR		217
ALG14, UDP-N-acetylglucosaminyltransferase subunit		TAEGU		180
ALG14, UDP-N-acetylglucosaminyltransferase subunit		FICAL		216
+113

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK011733 mRNA Translation: BAB27807.1 AK017354 mRNA Translation: BAC25513.1 BC002278 mRNA Translation: AAH02278.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17801.1
NCBI Reference Sequences More...RefSeqⁱ	NP_077140.1, NM_024178.2
UniGeneⁱ	Mm.269881

3D structure databases

ProteinModelPortalⁱ	Q9D081
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000038387

STRINGⁱ

10090.ENSMUSP00000038387

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GT1 Glycosyltransferase Family 1

CAZyⁱ

GT1 Glycosyltransferase Family 1

PTM databases

iPTMnetⁱ	Q9D081
PhosphoSitePlusⁱ	Q9D081

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9D081
PaxDbⁱ	Q9D081
PeptideAtlas More...PeptideAtlasⁱ	Q9D081
PRIDEⁱ	Q9D081

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000039442; ENSMUSP00000038387; ENSMUSG00000039887
GeneIDⁱ	66789
KEGGⁱ	mmu:66789
UCSC genome browser More...UCSCⁱ	uc008rdx.1 mouse

Organism-specific databases

CTDⁱ	199857
MGIⁱ	MGI:1914039 Alg14

Phylogenomic databases

eggNOGⁱ	KOG3339 Eukaryota ENOG4111QSM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002579
HOGENOMⁱ	HOG000182099
HOVERGENⁱ	HBG059605
InParanoidⁱ	Q9D081
KEGG Orthology (KO) More...KOⁱ	K07441
OMAⁱ	ESICRVK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0K4A
PhylomeDBⁱ	Q9D081
TreeFamⁱ	TF105628

Enzyme and pathway databases

Reactomeⁱ	R-MMU-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

Reactomeⁱ

R-MMU-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9D081
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000039887
ExpressionAtlasⁱ	Q9D081 baseline and differential
Genevisibleⁱ	Q9D081 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR013969 Oligosacch_biosynth_Alg14
PANTHERⁱ	PTHR12154 PTHR12154, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08660 Alg14, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ALG14_MOUSE
Accessionⁱ	Q9D081Primary (citable) accession number: Q9D081 Secondary accession number(s): Q8CEP2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
	Last sequence update:	June 1, 2001
	Last modified:	July 5, 2017
	This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9D081 (ALG14_MOUSE)

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UDP-N-acetylglucosamine transferase subunit ALG14 homolog

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Endoplasmic reticulum

Endoplasmic reticulum

Nucleus

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ