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UniProtKB - Q9D081 (ALG14_MOUSE)
Protein
UDP-N-acetylglucosamine transferase subunit ALG14 homolog
Gene
Alg14
Organism
Mus musculus (Mouse)
Status
Functioni
Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER (By similarity).
By similarityGO - Biological processi
- dolichol-linked oligosaccharide biosynthetic process Source: GO_Central
Enzyme and pathway databases
Reactomei | R-MMU-446193, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
Protein family/group databases
CAZyi | GT1, Glycosyltransferase Family 1 |
Names & Taxonomyi
Protein namesi | Recommended name: UDP-N-acetylglucosamine transferase subunit ALG14 homolog |
Gene namesi | Name:Alg14 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1914039, Alg14 |
VEuPathDBi | HostDB:ENSMUSG00000039887 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass membrane protein Sequence analysis
Nucleus
- Nucleus membrane By similarity; Single-pass membrane protein Sequence analysis
Endoplasmic reticulum
- UDP-N-acetylglucosamine transferase complex Source: GO_Central
Nucleus
- nuclear membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 3 | LumenalBy similarity | 3 | |
Transmembranei | 4 – 26 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 27 – 217 | CytoplasmicBy similarityAdd BLAST | 191 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000265117 | 1 – 217 | UDP-N-acetylglucosamine transferase subunit ALG14 homologAdd BLAST | 217 |
Proteomic databases
MaxQBi | Q9D081 |
PaxDbi | Q9D081 |
PeptideAtlasi | Q9D081 |
PRIDEi | Q9D081 |
ProteomicsDBi | 296193 |
PTM databases
iPTMneti | Q9D081 |
PhosphoSitePlusi | Q9D081 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000039887, Expressed in pineal body and 281 other tissues |
Genevisiblei | Q9D081, MM |
Interactioni
Subunit structurei
Heterodimer with ALG13 to form a functional enzyme.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000038387 |
Miscellaneous databases
RNActi | Q9D081, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the ALG14 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3339, Eukaryota |
GeneTreei | ENSGT00390000002579 |
HOGENOMi | CLU_064541_2_0_1 |
InParanoidi | Q9D081 |
OMAi | GPGTCCI |
OrthoDBi | 1449763at2759 |
PhylomeDBi | Q9D081 |
TreeFami | TF105628 |
Family and domain databases
InterProi | View protein in InterPro IPR013969, Oligosacch_biosynth_Alg14 |
PANTHERi | PTHR12154, PTHR12154, 1 hit |
Pfami | View protein in Pfam PF08660, Alg14, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9D081-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLSILILAAT AAGLVILLFQ RLWTVLGPHH VTPRESLRLL IVAGSGGHTT
60 70 80 90 100
EILRLVGSLS NAYSPRHYVI AESDEMSAKK IHSLEELSRA QNDSTTEYPK
110 120 130 140 150
YHLHRIPRSR EVRQSWLSSV FTTFYSMWFS FPLVLRIKPD LVLCNGPGTC
160 170 180 190 200
VPICVSALLL GILGVKKVII VYVESICRVE TLSLSGKILR HLSDYFIVQW
210
PTLKEKYPKS VYLGRIV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JEH5 | A0A0G2JEH5_MOUSE | UDP-N-acetylglucosamine transferase... | Alg14 | 133 | Annotation score: | ||
A0A0G2JEQ0 | A0A0G2JEQ0_MOUSE | UDP-N-acetylglucosamine transferase... | Alg14 | 92 | Annotation score: | ||
A0A0G2JF20 | A0A0G2JF20_MOUSE | UDP-N-acetylglucosamine transferase... | Alg14 | 60 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK011733 mRNA Translation: BAB27807.1 AK017354 mRNA Translation: BAC25513.1 BC002278 mRNA Translation: AAH02278.1 |
CCDSi | CCDS17801.1 |
RefSeqi | NP_077140.1, NM_024178.2 |
Genome annotation databases
Ensembli | ENSMUST00000039442; ENSMUSP00000038387; ENSMUSG00000039887 |
GeneIDi | 66789 |
KEGGi | mmu:66789 |
UCSCi | uc008rdx.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK011733 mRNA Translation: BAB27807.1 AK017354 mRNA Translation: BAC25513.1 BC002278 mRNA Translation: AAH02278.1 |
CCDSi | CCDS17801.1 |
RefSeqi | NP_077140.1, NM_024178.2 |
3D structure databases
SMRi | Q9D081 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000038387 |
Protein family/group databases
CAZyi | GT1, Glycosyltransferase Family 1 |
PTM databases
iPTMneti | Q9D081 |
PhosphoSitePlusi | Q9D081 |
Proteomic databases
MaxQBi | Q9D081 |
PaxDbi | Q9D081 |
PeptideAtlasi | Q9D081 |
PRIDEi | Q9D081 |
ProteomicsDBi | 296193 |
Protocols and materials databases
Antibodypediai | 53384, 86 antibodies from 18 providers |
DNASUi | 66789 |
Genome annotation databases
Ensembli | ENSMUST00000039442; ENSMUSP00000038387; ENSMUSG00000039887 |
GeneIDi | 66789 |
KEGGi | mmu:66789 |
UCSCi | uc008rdx.1, mouse |
Organism-specific databases
CTDi | 199857 |
MGIi | MGI:1914039, Alg14 |
VEuPathDBi | HostDB:ENSMUSG00000039887 |
Phylogenomic databases
eggNOGi | KOG3339, Eukaryota |
GeneTreei | ENSGT00390000002579 |
HOGENOMi | CLU_064541_2_0_1 |
InParanoidi | Q9D081 |
OMAi | GPGTCCI |
OrthoDBi | 1449763at2759 |
PhylomeDBi | Q9D081 |
TreeFami | TF105628 |
Enzyme and pathway databases
Reactomei | R-MMU-446193, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
Miscellaneous databases
BioGRID-ORCSi | 66789, 20 hits in 64 CRISPR screens |
PROi | PR:Q9D081 |
RNActi | Q9D081, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039887, Expressed in pineal body and 281 other tissues |
Genevisiblei | Q9D081, MM |
Family and domain databases
InterProi | View protein in InterPro IPR013969, Oligosacch_biosynth_Alg14 |
PANTHERi | PTHR12154, PTHR12154, 1 hit |
Pfami | View protein in Pfam PF08660, Alg14, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ALG14_MOUSE | |
Accessioni | Q9D081Primary (citable) accession number: Q9D081 Secondary accession number(s): Q8CEP2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families