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Protein

UDP-N-acetylglucosamine transferase subunit ALG14 homolog

Gene

Alg14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine transferase subunit ALG14 homolog
Gene namesi
Name:Alg14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1914039 Alg14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 3LumenalBy similarity3
Transmembranei4 – 26HelicalSequence analysisAdd BLAST23
Topological domaini27 – 217CytoplasmicBy similarityAdd BLAST191

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002651171 – 217UDP-N-acetylglucosamine transferase subunit ALG14 homologAdd BLAST217

Proteomic databases

MaxQBiQ9D081
PaxDbiQ9D081
PeptideAtlasiQ9D081
PRIDEiQ9D081

PTM databases

iPTMnetiQ9D081
PhosphoSitePlusiQ9D081

Expressioni

Gene expression databases

BgeeiENSMUSG00000039887
ExpressionAtlasiQ9D081 baseline and differential
GenevisibleiQ9D081 MM

Interactioni

Subunit structurei

Heterodimer with ALG13 to form a functional enzyme.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038387

Structurei

3D structure databases

ProteinModelPortaliQ9D081
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ALG14 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3339 Eukaryota
ENOG4111QSM LUCA
GeneTreeiENSGT00390000002579
HOGENOMiHOG000182099
HOVERGENiHBG059605
InParanoidiQ9D081
KOiK07441
OMAiESICRVK
OrthoDBiEOG091G0K4A
PhylomeDBiQ9D081
TreeFamiTF105628

Family and domain databases

InterProiView protein in InterPro
IPR013969 Oligosacch_biosynth_Alg14
PANTHERiPTHR12154 PTHR12154, 1 hit
PfamiView protein in Pfam
PF08660 Alg14, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D081-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSILILAAT AAGLVILLFQ RLWTVLGPHH VTPRESLRLL IVAGSGGHTT
60 70 80 90 100
EILRLVGSLS NAYSPRHYVI AESDEMSAKK IHSLEELSRA QNDSTTEYPK
110 120 130 140 150
YHLHRIPRSR EVRQSWLSSV FTTFYSMWFS FPLVLRIKPD LVLCNGPGTC
160 170 180 190 200
VPICVSALLL GILGVKKVII VYVESICRVE TLSLSGKILR HLSDYFIVQW
210
PTLKEKYPKS VYLGRIV
Length:217
Mass (Da):24,429
Last modified:June 1, 2001 - v1
Checksum:i471268EC8AF6BF15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011733 mRNA Translation: BAB27807.1
AK017354 mRNA Translation: BAC25513.1
BC002278 mRNA Translation: AAH02278.1
CCDSiCCDS17801.1
RefSeqiNP_077140.1, NM_024178.2
UniGeneiMm.269881

Genome annotation databases

EnsembliENSMUST00000039442; ENSMUSP00000038387; ENSMUSG00000039887
GeneIDi66789
KEGGimmu:66789
UCSCiuc008rdx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiALG14_MOUSE
AccessioniPrimary (citable) accession number: Q9D081
Secondary accession number(s): Q8CEP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2001
Last modified: July 5, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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