E3 ubiquitin-protein ligase MGRN1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• metal ion binding Source: UniProtKB-KW
• ubiquitin protein ligase activity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 12560552
• ubiquitin-protein transferase activity Source: UniProtKB

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• endosome to lysosome transport Source: MGI
• negative regulation of cAMP-mediated signaling Source: UniProtKB
• negative regulation of G-protein coupled receptor protein signaling pathway Source: UniProtKB
• negative regulation of smoothened signaling pathway Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 29290584
• protein monoubiquitination Source: MGI
• protein polyubiquitination Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 12560552

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Motif

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Zinc finger

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MGSILSRRIA GVEDIDIQAN SAYRYPPKSG NYFASHFFMG GEKFDTPHPE 
        60         70         80         90        100
GYLFGENMDL NFLGSRPVQF PYVTPAPHEP VKTLRSLVNI RKDSLRLVRY 
       110        120        130        140        150
KEDADSPTED GEKPRVLYSL EFTFDADARV AITIYCQAVE ELVNGVAVYS 
       160        170        180        190        200
CKNPSLQSET VHYKRGVSQQ FSLPSFKIDF SEWKDDELNF DLDRGVFPVV 
       210        220        230        240        250
IQAVVDEGDV VEVTGHAHVL LAAFEKHVDG SFSVKPLKQK QIVDRVSYLL 
       260        270        280        290        300
QEIYGIENKN NQETKPSDDE NSDNSSECVV CLSDLRDTLI LPCRHLCLCT 
       310        320        330        340        350
SCADTLRYQA NNCPICRLPF RALLQIRAVR KKPGALSPIS FSPVLAQSVD 
       360        370        380        390        400
HDEHSSSDSI PPGYEPISLL EALNGLRAVS PAIPSAPLYE EITYSGISDG 
       410        420        430        440        450
LSQASCPLAG LDRIMESGLQ KGKTQSKSPD STLRSPSFPI HEEDEEKLSE 
       460        470        480        490        500
DSDAPLPPSG VELVLRESSS PESFGTEEGD EPSLKQGSRV PSIDDVLQDG 
       510        520        530 
SPQHHGCSQP VPPADIYLPA LGPESCSVGI EE                    

        10         20         30         40         50
MGSILSRRIA GVEDIDIQAN SAYRYPPKSA GNYFASHFFM GGEKFDTPHP 
        60         70         80         90        100
EGYLFGENMD LNFLGSRPVQ FPYVTPAPHE PVKTLRSLVN IRKDSLRLVR 
       110        120        130        140        150
YKEDADSPTE DGEKPRVLYS LEFTFDADAR VAITIYCQAV EELVNGVAVY 
       160        170        180        190        200
SCKNPSLQSE TVHYKRGVSQ QFSLPSFKID FSEWKDDELN FDLDRGVFPV 
       210        220        230        240        250
VIQAVVDEGD VVEVTGHAHV LLAAFEKHVD GSFSVKPLKQ KQIVDRVSYL 
       260        270        280        290        300
LQEIYGIENK NNQETKPSDD ENSDNSSECV VCLSDLRDTL ILPCRHLCLC 
       310        320        330        340        350
TSCADTLRYQ ANNCPICRLP FRALLQIRAV RKKPGALSPI SFSPVLAQSV 
       360        370        380        390        400
DHDEHSSSDS IPPGYEPISL LEALNGLRAV SPAIPSAPLY EEITYSGISD 
       410        420        430        440        450
GLSQASCPLA GLDRIMESGL QKGKTQSKSP DSTLRSPSFP IHEEDEEKLS 
       460        470        480        490        500
EDSDAPLPPS GVELVLRESS SPESFGTEEG DEPSLKQGSR VPSIDDVLQD 
       510        520        530 
GSPQHHGCSQ PVPPADIYLP ALGPESCSVG IEE                   

        10         20         30         40         50
MGSILSRRIA GVEDIDIQAN SAYRYPPKSG NYFASHFFMG GEKFDTPHPE 
        60         70         80         90        100
GYLFGENMDL NFLGSRPVQF PYVTPAPHEP VKTLRSLVNI RKDSLRLVRY 
       110        120        130        140        150
KEDADSPTED GEKPRVLYSL EFTFDADARV AITIYCQAVE ELVNGVAVYS 
       160        170        180        190        200
CKNPSLQSET VHYKRGVSQQ FSLPSFKIDF SEWKDDELNF DLDRGVFPVV 
       210        220        230        240        250
IQAVVDEGDV VEVTGHAHVL LAAFEKHVDG SFSVKPLKQK QIVDRVSYLL 
       260        270        280        290        300
QEIYGIENKN NQETKPSDDE NSDNSSECVV CLSDLRDTLI LPCRHLCLCT 
       310        320        330        340        350
SCADTLRYQA NNCPICRLPF RALLQIRAVR KKPGALSPIS FSPVLAQSVD 
       360        370        380        390        400
HDEHSSSDSI PPGYEPISLL EALNGLRAVS PAIPSAPLYE EITYSGISDG 
       410        420        430        440        450
LSQASCPLAG LDRIMESGLQ KGKTQSKSPD STLRSPSFPI HEEDEEKLSE 
       460        470        480        490        500
DSDAPLPPSG VELVLRESSS PESFGTEEGD EPSLKQGSRV PSIDDVLQDG 
       510        520        530        540        550
SPQHHGCSQP VPPADIYLPG WSTSMETPHS LGTTSSPWPL LSGSSPEPGV 

AELTPF                                                 

        10         20         30         40         50
MGSILSRRIA GVEDIDIQAN SAYRYPPKSG NYFASHFFMG GEKFDTPHPE 
        60         70         80         90        100
GYLFGENMDL NFLGSRPVQF PYVTPAPHEP VKTLRSLVNI RKDSLRLVRY 
       110        120        130        140        150
KEDADSPTED GEKPRVLYSL EFTFDADARV AITIYCQAVE ELVNGVAVYS 
       160        170        180        190        200
CKNPSLQSET VHYKRGVSQQ FSLPSFKIDF SEWKDDELNF DLDRGVFPVV 
       210        220        230        240        250
IQAVVDEGDV VEVTGHAHVL LAAFEKHVDG SFSVKPLKQK QIVDRVSYLL 
       260        270        280        290        300
QEIYGIENKN NQETKPSDDE NSDNSSECVV CLSDLRDTLI LPCRHLCLCT 
       310        320        330        340        350
SCADTLRYQA NNCPICRLPF RALLQIRAVR KKPGALSPIS FSPVLAQSVD 
       360        370        380        390        400
HDEHSCPFKK SKSHPASLAS KKPKRETSSD SIPPGYEPIS LLEALNGLRA 
       410        420        430        440        450
VSPAIPSAPL YEEITYSGIS DGLSQASCPL AGLDRIMESG LQKGKTQSKS 
       460        470        480        490        500
PDSTLRSPSF PIHEEDEEKL SEDSDAPLPP SGVELVLRES SSPESFGTEE 
       510        520        530        540        550
GDEPSLKQGS RVPSIDDVLQ DGSPQHHGCS QPVPPADIYL PALGPESCSV 

GIEE                                                   

        10         20         30         40         50
MGSILSRRIA GVEDIDIQAN SAYRYPPKSG NYFASHFFMG GEKFDTPHPE 
        60         70         80         90        100
GYLFGENMDL NFLGSRPVQF PYVTPAPHEP VKTLRSLVNI RKDSLRLVRY 
       110        120        130        140        150
KEDADSPTED GEKPRVLYSL EFTFDADARV AITIYCQAVE ELVNGVAVYS 
       160        170        180        190        200
CKNPSLQSET VHYKRGVSQQ FSLPSFKIDF SEWKDDELNF DLDRGVFPVV 
       210        220        230        240        250
IQAVVDEGDV VEVTGHAHVL LAAFEKHVDG SFSVKPLKQK QIVDRVSYLL 
       260        270        280        290        300
QEIYGIENKN NQETKPSDDE NSDNSSECVV CLSDLRDTLI LPCRHLCLCT 
       310        320        330        340        350
SCADTLRYQA NNCPICRLPF RALLQIRAVR KKPGALSPIS FSPVLAQSVD 
       360        370        380        390        400
HDEHSCPFKK SKSHPASLAS KKPKRETSSD SIPPGYEPIS LLEALNGLRA 
       410        420        430        440        450
VSPAIPSAPL YEEITYSGIS DGLSQASCPL AGLDRIMESG LQKGKTQSKS 
       460        470        480        490        500
PDSTLRSPSF PIHEEDEEKL SEDSDAPLPP SGVELVLRES SSPESFGTEE 
       510        520        530        540        550
GDEPSLKQGS RVPSIDDVLQ DGSPQHHGCS QPVPPADIYL PGWSTSMETP 
       560        570 
HSLGTTSSPW PLLSGSSPEP GVAELTPF                         

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. PATHWAY comments
   Index of metabolic and biosynthesis pathways