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Entry version 145 (02 Jun 2021)
Sequence version 1 (01 Jun 2001)
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Protein

MMS19 nucleotide excision repair protein homolog

Gene

Mms19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target Fe/S proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription. As a CIA complex component and in collaboration with CIAO1 and CIAO2, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Together with CIAO2, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processChromosome partition, DNA damage, DNA repair, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MMS19 nucleotide excision repair protein homolog
Alternative name(s):
MET18 homolog
MMS19-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mms19
Synonyms:Mms19l
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1919449, Mms19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonically lethality before the implantation stage.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000965152 – 1031MMS19 nucleotide excision repair protein homologAdd BLAST1030

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei1028PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9D071

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9D071

PeptideAtlas

More...
PeptideAtlasi
Q9D071

PRoteomics IDEntifications database

More...
PRIDEi
Q9D071

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
252579 [Q9D071-1]
252580 [Q9D071-2]
252581 [Q9D071-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9D071

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9D071

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9D071

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed with higher expression in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000025159, Expressed in embryonic stem cell and 302 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9D071, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9D071, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the CIA complex. In the CIA complex, interacts directly with CIAO2B and CIAO3.

Component of the MMXD complex, composed of CIAO1, ERCC2, CIAO2B, MMS19 and SLC25A5.

Interacts with CIAO2B; the interaction is direct.

Interacts with ERCC2/XPD; the interaction is direct.

Interacts with ERCC3/XPB and NCOA3/RAC3.

Interacts with RTEL1; the interaction mediates the association of RTEL1 with the CIA complex.

Interacts with BRIP1.

Interacts with KIF4A; the interaction facilitates the transfer of Fe-S clusters to KIF4A to ensure proper localization of KIF4A to the mitotic machinery components.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
215214, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q9D071, 9 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000130900

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9D071, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9D071

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati867 – 905HEAT 1Add BLAST39
Repeati909 – 947HEAT 2Add BLAST39
Repeati950 – 988HEAT 3Add BLAST39
Repeati991 – 1029HEAT 4Add BLAST39

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MET18/MMS19 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1967, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015583

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9D071

Identification of Orthologs from Complete Genome Data

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OMAi
FEIFACY

Database of Orthologous Groups

More...
OrthoDBi
944339at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9D071

TreeFam database of animal gene trees

More...
TreeFami
TF314469

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR039920, MET18/MMS19
IPR024687, MMS19_C
IPR029240, MMS19_N

The PANTHER Classification System

More...
PANTHERi
PTHR12891, PTHR12891, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12460, MMS19_C, 1 hit
PF14500, MMS19_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D071-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAATGLEEA VAPMGALCGL VQDFVMGQQE GPADQVAADV KSGGYTVLQV
60 70 80 90 100
VEALGSSLEN AEPRTRARGA QLLSQVLLQC HSLLSEKEVV HLILFYENRL
110 120 130 140 150
KDHHLVVPSV LQGLRALSMS VALPPGLAVS VLKAIFQEVH VQSLLQVDRH
160 170 180 190 200
TVFSIITNFM RSREEELKGL GADFTFGFIQ VMDGEKDPRN LLLAFRIVHD
210 220 230 240 250
LISKDYSLGP FVEELFEVTS CYFPIDFTPP PNDPYGIQRE DLILSLRAVL
260 270 280 290 300
ASTPRFAEFL LPLLIEKVDS EILSAKLDSL QTLNACCAVY GQKELKDFLP
310 320 330 340 350
SLWASIRREV FQTASERVEA EGLAALHSLT ACLSCSVLRA DAEDLLGSFL
360 370 380 390 400
SNILQDCRHH LCEPDMKLVW PSAKLLQAAA GASARACEHL TSNVLPLLLE
410 420 430 440 450
QFHKHSQSNQ RRTILEMILG FLKLQQKWSY EDRDERPLSS FKDQLCSLVF
460 470 480 490 500
MALTDPSTQL QLVGIRTLTV LGAQPGLLSA EDLELAVGHL YRLTFLEEDS
510 520 530 540 550
QSCRVAALEA SGTLATLYPG AFSRHLLPKL AEELHKGESD VARADGPTKC
560 570 580 590 600
SRHFRCLQAL SAVSTHPSIV KETLPLLLQH LCQANKGNMV TESSEVVAVC
610 620 630 640 650
QSLQQVAEKC QQDPESYWYF HKTAVPCLFA LAVQASMPEK ESSVLRKVLL
660 670 680 690 700
EDEVLAALAS VIGTATTHLS PELAAQSVTC IVPLFLDGNT SFLPENSFPD
710 720 730 740 750
QFQPFQDGSS GQRRLVALLT AFVCSLPRNV EIPQLNRLMR ELLKQSCGHS
760 770 780 790 800
CPFSSTAATK CFAGLLNKQP PGQQLEEFLQ LAVGTVEAGL ASESSRDQAF
810 820 830 840 850
TLLLWVTKAL VLRYHPLSAC LTTRLMGLLS DPELGCAAAD GFSLLMSDCT
860 870 880 890 900
DVLTRAGHAD VRIMFRQRFF TDNVPALVQG FHAAPQDVKP NYLKGLSHVL
910 920 930 940 950
NRLPKPVLLP ELPTLLSLLL EALSCPDSVV QLSTLSCLQP LLLEAPQIMS
960 970 980 990 1000
LHVDTLVTKF LNLSSSYSMA VRIAALQCMH ALTRLPTSVL LPYKSQVIRA
1010 1020 1030
LAKPLDDKKR LVRKEAVSAR GEWFLLGSPG S
Length:1,031
Mass (Da):113,089
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4A3FBD0A1E52FA2D
GO
Isoform 2 (identifier: Q9D071-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     887-889: DVK → GES
     890-1031: Missing.

Show »
Length:889
Mass (Da):97,459
Checksum:i4ADAB1269820BF6A
GO
Isoform 3 (identifier: Q9D071-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     166-208: Missing.

Show »
Length:988
Mass (Da):108,223
Checksum:i8EDCD18048EB5E88
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7C9N6F7C9N6_MOUSE
MMS19 nucleotide excision repair pr...
Mms19
885Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RGK4F6RGK4_MOUSE
MMS19 nucleotide excision repair pr...
Mms19
286Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q5T0E9Q5T0_MOUSE
MMS19 nucleotide excision repair pr...
Mms19
174Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7A0X7F7A0X7_MOUSE
MMS19 nucleotide excision repair pr...
Mms19
501Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TJQ8F6TJQ8_MOUSE
MMS19 nucleotide excision repair pr...
Mms19
129Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PW47E9PW47_MOUSE
MMS19 nucleotide excision repair pr...
Mms19
357Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PUY8E9PUY8_MOUSE
MMS19 nucleotide excision repair pr...
Mms19
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti16A → P in BAB26853 (PubMed:16141072).Curated1
Sequence conflicti237I → V in AAK52670 (PubMed:11328871).Curated1
Sequence conflicti681I → V in AAK52670 (PubMed:11328871).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_044184166 – 208Missing in isoform 3. CuratedAdd BLAST43
Alternative sequenceiVSP_015569887 – 889DVK → GES in isoform 2. 1 Publication3
Alternative sequenceiVSP_015570890 – 1031Missing in isoform 2. 1 PublicationAdd BLAST142

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF319949 mRNA Translation: AAK52670.1
AK010326 mRNA Translation: BAB26853.1
AK011754 mRNA Translation: BAB27822.1
AK028317 mRNA Translation: BAC25875.1
AK030619 mRNA Translation: BAC27050.1
AK036983 mRNA Translation: BAC29658.1
AC140193 Genomic DNA No translation available.
BC050817 mRNA Translation: AAH50817.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS29818.1 [Q9D071-1]

NCBI Reference Sequences

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RefSeqi
NP_082428.1, NM_028152.3 [Q9D071-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000026168; ENSMUSP00000026168; ENSMUSG00000025159 [Q9D071-3]
ENSMUST00000171561; ENSMUSP00000130900; ENSMUSG00000025159 [Q9D071-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
72199

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:72199

UCSC genome browser

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UCSCi
uc008hmv.1, mouse [Q9D071-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319949 mRNA Translation: AAK52670.1
AK010326 mRNA Translation: BAB26853.1
AK011754 mRNA Translation: BAB27822.1
AK028317 mRNA Translation: BAC25875.1
AK030619 mRNA Translation: BAC27050.1
AK036983 mRNA Translation: BAC29658.1
AC140193 Genomic DNA No translation available.
BC050817 mRNA Translation: AAH50817.1
CCDSiCCDS29818.1 [Q9D071-1]
RefSeqiNP_082428.1, NM_028152.3 [Q9D071-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6TBLX-ray2.65A/B911-1031[»]
6TC0X-ray3.60C/F1-1031[»]
SMRiQ9D071
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi215214, 12 interactors
IntActiQ9D071, 9 interactors
STRINGi10090.ENSMUSP00000130900

PTM databases

iPTMnetiQ9D071
PhosphoSitePlusiQ9D071
SwissPalmiQ9D071

Proteomic databases

EPDiQ9D071
PaxDbiQ9D071
PeptideAtlasiQ9D071
PRIDEiQ9D071
ProteomicsDBi252579 [Q9D071-1]
252580 [Q9D071-2]
252581 [Q9D071-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
30936, 167 antibodies

The DNASU plasmid repository

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DNASUi
72199

Genome annotation databases

EnsembliENSMUST00000026168; ENSMUSP00000026168; ENSMUSG00000025159 [Q9D071-3]
ENSMUST00000171561; ENSMUSP00000130900; ENSMUSG00000025159 [Q9D071-1]
GeneIDi72199
KEGGimmu:72199
UCSCiuc008hmv.1, mouse [Q9D071-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64210
MGIiMGI:1919449, Mms19

Phylogenomic databases

eggNOGiKOG1967, Eukaryota
GeneTreeiENSGT00390000015583
InParanoidiQ9D071
OMAiFEIFACY
OrthoDBi944339at2759
PhylomeDBiQ9D071
TreeFamiTF314469

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
72199, 21 hits in 53 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Mms19, mouse

Protein Ontology

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PROi
PR:Q9D071
RNActiQ9D071, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000025159, Expressed in embryonic stem cell and 302 other tissues
ExpressionAtlasiQ9D071, baseline and differential
GenevisibleiQ9D071, MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR039920, MET18/MMS19
IPR024687, MMS19_C
IPR029240, MMS19_N
PANTHERiPTHR12891, PTHR12891, 1 hit
PfamiView protein in Pfam
PF12460, MMS19_C, 1 hit
PF14500, MMS19_N, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMMS19_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9D071
Secondary accession number(s): F8WHX3, Q925N8, Q9CWX3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: June 1, 2001
Last modified: June 2, 2021
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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