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Protein

MMS19 nucleotide excision repair protein homolog

Gene

Mms19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target Fe/S proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription. As a CIA complex component and in collaboration with CIAO1 and CIAO2, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.By similarity

GO - Molecular functioni

  • enzyme binding Source: BHF-UCL
  • estrogen receptor binding Source: MGI
  • transcription coactivator activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processChromosome partition, DNA damage, DNA repair, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
MMS19 nucleotide excision repair protein homolog
Alternative name(s):
MET18 homolog
MMS19-like protein
Gene namesi
Name:Mms19
Synonyms:Mms19l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1919449 Mms19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryonically lethality before the implantation stage.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000965152 – 1031MMS19 nucleotide excision repair protein homologAdd BLAST1030

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei1028PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9D071
PaxDbiQ9D071
PeptideAtlasiQ9D071
PRIDEiQ9D071

PTM databases

iPTMnetiQ9D071
PhosphoSitePlusiQ9D071
SwissPalmiQ9D071

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression in testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000025159 Expressed in 279 organ(s), highest expression level in embryonic stem cell
CleanExiMM_MMS19
ExpressionAtlasiQ9D071 baseline and differential
GenevisibleiQ9D071 MM

Interactioni

Subunit structurei

Component of the CIA complex. In the CIA complex, interacts directly with CIAO2B and CIAO3. Component of the MMXD complex, composed of CIAO1, ERCC2, CIAO2B, MMS19 and SLC25A5. Interacts with CIAO2B; the interaction is direct. Interacts with ERCC2/XPD; the interaction is direct. Interacts with ERCC3/XPB and NCOA3/RAC3. Interacts with RTEL1; the interaction mediates the association of RTEL1 with the CIA complex. Interacts with BRIP1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi215214, 11 interactors
IntActiQ9D071, 6 interactors
STRINGi10090.ENSMUSP00000130900

Structurei

3D structure databases

ProteinModelPortaliQ9D071
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati867 – 905HEAT 1Add BLAST39
Repeati909 – 947HEAT 2Add BLAST39
Repeati950 – 988HEAT 3Add BLAST39
Repeati991 – 1029HEAT 4Add BLAST39

Sequence similaritiesi

Belongs to the MET18/MMS19 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1967 Eukaryota
ENOG410XNMZ LUCA
GeneTreeiENSGT00390000015583
HOGENOMiHOG000038024
HOVERGENiHBG057358
InParanoidiQ9D071
KOiK15075
OMAiFEIFACY
OrthoDBiEOG091G00K8
PhylomeDBiQ9D071
TreeFamiTF314469

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039920 MET18/MMS19
IPR024687 MMS19_C
IPR029240 MMS19_N
PANTHERiPTHR12891 PTHR12891, 1 hit
PfamiView protein in Pfam
PF12460 MMS19_C, 1 hit
PF14500 MMS19_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D071-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAATGLEEA VAPMGALCGL VQDFVMGQQE GPADQVAADV KSGGYTVLQV
60 70 80 90 100
VEALGSSLEN AEPRTRARGA QLLSQVLLQC HSLLSEKEVV HLILFYENRL
110 120 130 140 150
KDHHLVVPSV LQGLRALSMS VALPPGLAVS VLKAIFQEVH VQSLLQVDRH
160 170 180 190 200
TVFSIITNFM RSREEELKGL GADFTFGFIQ VMDGEKDPRN LLLAFRIVHD
210 220 230 240 250
LISKDYSLGP FVEELFEVTS CYFPIDFTPP PNDPYGIQRE DLILSLRAVL
260 270 280 290 300
ASTPRFAEFL LPLLIEKVDS EILSAKLDSL QTLNACCAVY GQKELKDFLP
310 320 330 340 350
SLWASIRREV FQTASERVEA EGLAALHSLT ACLSCSVLRA DAEDLLGSFL
360 370 380 390 400
SNILQDCRHH LCEPDMKLVW PSAKLLQAAA GASARACEHL TSNVLPLLLE
410 420 430 440 450
QFHKHSQSNQ RRTILEMILG FLKLQQKWSY EDRDERPLSS FKDQLCSLVF
460 470 480 490 500
MALTDPSTQL QLVGIRTLTV LGAQPGLLSA EDLELAVGHL YRLTFLEEDS
510 520 530 540 550
QSCRVAALEA SGTLATLYPG AFSRHLLPKL AEELHKGESD VARADGPTKC
560 570 580 590 600
SRHFRCLQAL SAVSTHPSIV KETLPLLLQH LCQANKGNMV TESSEVVAVC
610 620 630 640 650
QSLQQVAEKC QQDPESYWYF HKTAVPCLFA LAVQASMPEK ESSVLRKVLL
660 670 680 690 700
EDEVLAALAS VIGTATTHLS PELAAQSVTC IVPLFLDGNT SFLPENSFPD
710 720 730 740 750
QFQPFQDGSS GQRRLVALLT AFVCSLPRNV EIPQLNRLMR ELLKQSCGHS
760 770 780 790 800
CPFSSTAATK CFAGLLNKQP PGQQLEEFLQ LAVGTVEAGL ASESSRDQAF
810 820 830 840 850
TLLLWVTKAL VLRYHPLSAC LTTRLMGLLS DPELGCAAAD GFSLLMSDCT
860 870 880 890 900
DVLTRAGHAD VRIMFRQRFF TDNVPALVQG FHAAPQDVKP NYLKGLSHVL
910 920 930 940 950
NRLPKPVLLP ELPTLLSLLL EALSCPDSVV QLSTLSCLQP LLLEAPQIMS
960 970 980 990 1000
LHVDTLVTKF LNLSSSYSMA VRIAALQCMH ALTRLPTSVL LPYKSQVIRA
1010 1020 1030
LAKPLDDKKR LVRKEAVSAR GEWFLLGSPG S
Length:1,031
Mass (Da):113,089
Last modified:June 1, 2001 - v1
Checksum:i4A3FBD0A1E52FA2D
GO
Isoform 2 (identifier: Q9D071-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     887-889: DVK → GES
     890-1031: Missing.

Note: No experimental confirmation available.
Show »
Length:889
Mass (Da):97,459
Checksum:i4ADAB1269820BF6A
GO
Isoform 3 (identifier: Q9D071-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     166-208: Missing.

Note: No experimental confirmation available.
Show »
Length:988
Mass (Da):108,223
Checksum:i8EDCD18048EB5E88
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7C9N6F7C9N6_MOUSE
MMS19 nucleotide excision repair pr...
Mms19
885Annotation score:
F7A0X7F7A0X7_MOUSE
MMS19 nucleotide excision repair pr...
Mms19
501Annotation score:
E9Q5T0E9Q5T0_MOUSE
MMS19 nucleotide excision repair pr...
Mms19
174Annotation score:
F6RGK4F6RGK4_MOUSE
MMS19 nucleotide excision repair pr...
Mms19
286Annotation score:
F6TJQ8F6TJQ8_MOUSE
MMS19 nucleotide excision repair pr...
Mms19
129Annotation score:
E9PW47E9PW47_MOUSE
MMS19 nucleotide excision repair pr...
Mms19
357Annotation score:
E9PUY8E9PUY8_MOUSE
MMS19 nucleotide excision repair pr...
Mms19
75Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16A → P in BAB26853 (PubMed:16141072).Curated1
Sequence conflicti237I → V in AAK52670 (PubMed:11328871).Curated1
Sequence conflicti681I → V in AAK52670 (PubMed:11328871).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044184166 – 208Missing in isoform 3. CuratedAdd BLAST43
Alternative sequenceiVSP_015569887 – 889DVK → GES in isoform 2. 1 Publication3
Alternative sequenceiVSP_015570890 – 1031Missing in isoform 2. 1 PublicationAdd BLAST142

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319949 mRNA Translation: AAK52670.1
AK010326 mRNA Translation: BAB26853.1
AK011754 mRNA Translation: BAB27822.1
AK028317 mRNA Translation: BAC25875.1
AK030619 mRNA Translation: BAC27050.1
AK036983 mRNA Translation: BAC29658.1
AC140193 Genomic DNA No translation available.
BC050817 mRNA Translation: AAH50817.1
CCDSiCCDS29818.1 [Q9D071-1]
RefSeqiNP_082428.1, NM_028152.3 [Q9D071-1]
UniGeneiMm.218940

Genome annotation databases

EnsembliENSMUST00000026168; ENSMUSP00000026168; ENSMUSG00000025159 [Q9D071-3]
ENSMUST00000171561; ENSMUSP00000130900; ENSMUSG00000025159 [Q9D071-1]
GeneIDi72199
KEGGimmu:72199
UCSCiuc008hmv.1 mouse [Q9D071-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319949 mRNA Translation: AAK52670.1
AK010326 mRNA Translation: BAB26853.1
AK011754 mRNA Translation: BAB27822.1
AK028317 mRNA Translation: BAC25875.1
AK030619 mRNA Translation: BAC27050.1
AK036983 mRNA Translation: BAC29658.1
AC140193 Genomic DNA No translation available.
BC050817 mRNA Translation: AAH50817.1
CCDSiCCDS29818.1 [Q9D071-1]
RefSeqiNP_082428.1, NM_028152.3 [Q9D071-1]
UniGeneiMm.218940

3D structure databases

ProteinModelPortaliQ9D071
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215214, 11 interactors
IntActiQ9D071, 6 interactors
STRINGi10090.ENSMUSP00000130900

PTM databases

iPTMnetiQ9D071
PhosphoSitePlusiQ9D071
SwissPalmiQ9D071

Proteomic databases

EPDiQ9D071
PaxDbiQ9D071
PeptideAtlasiQ9D071
PRIDEiQ9D071

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026168; ENSMUSP00000026168; ENSMUSG00000025159 [Q9D071-3]
ENSMUST00000171561; ENSMUSP00000130900; ENSMUSG00000025159 [Q9D071-1]
GeneIDi72199
KEGGimmu:72199
UCSCiuc008hmv.1 mouse [Q9D071-1]

Organism-specific databases

CTDi64210
MGIiMGI:1919449 Mms19

Phylogenomic databases

eggNOGiKOG1967 Eukaryota
ENOG410XNMZ LUCA
GeneTreeiENSGT00390000015583
HOGENOMiHOG000038024
HOVERGENiHBG057358
InParanoidiQ9D071
KOiK15075
OMAiFEIFACY
OrthoDBiEOG091G00K8
PhylomeDBiQ9D071
TreeFamiTF314469

Miscellaneous databases

PROiPR:Q9D071
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025159 Expressed in 279 organ(s), highest expression level in embryonic stem cell
CleanExiMM_MMS19
ExpressionAtlasiQ9D071 baseline and differential
GenevisibleiQ9D071 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039920 MET18/MMS19
IPR024687 MMS19_C
IPR029240 MMS19_N
PANTHERiPTHR12891 PTHR12891, 1 hit
PfamiView protein in Pfam
PF12460 MMS19_C, 1 hit
PF14500 MMS19_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMMS19_MOUSE
AccessioniPrimary (citable) accession number: Q9D071
Secondary accession number(s): F8WHX3, Q925N8, Q9CWX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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