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Protein

Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

Gene

Nkain1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ATPase binding Source: MGI

GO - Biological processi

  • regulation of sodium ion transport Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1
Short name:
Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 1
Alternative name(s):
Protein FAM77C
Gene namesi
Name:Nkain1
Synonyms:Fam77c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1914399 Nkain1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002636441 – 207Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1Add BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9D035
PaxDbiQ9D035
PRIDEiQ9D035

PTM databases

iPTMnetiQ9D035
PhosphoSitePlusiQ9D035

Expressioni

Tissue specificityi

Detected in the brain only and specifically in neurons. Expressed in multiple regions such as cerebral cortex, thalamus, hippocampus, olfactory bulb and brainstem as well as in cerebellum with high expression in granular cell layer.1 Publication

Gene expression databases

BgeeiENSMUSG00000078532 Expressed in 111 organ(s), highest expression level in cerebellum
CleanExiMM_NKAIN1
ExpressionAtlasiQ9D035 baseline and differential
GenevisibleiQ9D035 MM

Interactioni

Subunit structurei

Interacts with ATP1B1 C-terminus.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101614

Family & Domainsi

Sequence similaritiesi

Belongs to the NKAIN family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4556 Eukaryota
ENOG410XS8X LUCA
GeneTreeiENSGT00390000013699
HOGENOMiHOG000293382
HOVERGENiHBG108190
InParanoidiQ9D035
KOiK22735
OMAiLVICSLQ
OrthoDBiEOG091G0X6F
PhylomeDBiQ9D035
TreeFamiTF321348

Family and domain databases

InterProiView protein in InterPro
IPR008516 Na/K-Atpase_Interacting
PANTHERiPTHR13084 PTHR13084, 1 hit
PfamiView protein in Pfam
PF05640 NKAIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D035-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKCSGRCTL VAFCCLQLVA ALQRQIFDFL GYQWAPILAN FLHIMAVILG
60 70 80 90 100
IFGTVQYRSR YLILYAAWLV LWVGWNAFII CFYLEVGQLS QDRDFIMTFN
110 120 130 140 150
TSLHRSWWME NGPGCLVTPV LNSRLALEDH HVISVTGCLL DYPYIEALSS
160 170 180 190 200
ALQIFLALFG FVFACYVSKV FLEEEDSFDF IGGFDSYGYQ APQKTSHLQL

QPLYTSG
Length:207
Mass (Da):23,551
Last modified:December 12, 2006 - v2
Checksum:i52083EAC7A364E2A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QWW7M0QWW7_MOUSE
Sodium/potassium-transporting ATPas...
Nkain1
102Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF058048 mRNA Translation: ABN51166.1
AK011164 mRNA Translation: BAB27441.1
AK011850 mRNA Translation: BAB27879.1
BC116391 mRNA Translation: AAI16392.1
CCDSiCCDS57302.1
RefSeqiNP_080274.2, NM_025998.3
UniGeneiMm.423029

Genome annotation databases

EnsembliENSMUST00000105993; ENSMUSP00000101614; ENSMUSG00000078532
GeneIDi67149
KEGGimmu:67149
UCSCiuc008uzi.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF058048 mRNA Translation: ABN51166.1
AK011164 mRNA Translation: BAB27441.1
AK011850 mRNA Translation: BAB27879.1
BC116391 mRNA Translation: AAI16392.1
CCDSiCCDS57302.1
RefSeqiNP_080274.2, NM_025998.3
UniGeneiMm.423029

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101614

PTM databases

iPTMnetiQ9D035
PhosphoSitePlusiQ9D035

Proteomic databases

MaxQBiQ9D035
PaxDbiQ9D035
PRIDEiQ9D035

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105993; ENSMUSP00000101614; ENSMUSG00000078532
GeneIDi67149
KEGGimmu:67149
UCSCiuc008uzi.2 mouse

Organism-specific databases

CTDi79570
MGIiMGI:1914399 Nkain1

Phylogenomic databases

eggNOGiKOG4556 Eukaryota
ENOG410XS8X LUCA
GeneTreeiENSGT00390000013699
HOGENOMiHOG000293382
HOVERGENiHBG108190
InParanoidiQ9D035
KOiK22735
OMAiLVICSLQ
OrthoDBiEOG091G0X6F
PhylomeDBiQ9D035
TreeFamiTF321348

Miscellaneous databases

PROiPR:Q9D035
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000078532 Expressed in 111 organ(s), highest expression level in cerebellum
CleanExiMM_NKAIN1
ExpressionAtlasiQ9D035 baseline and differential
GenevisibleiQ9D035 MM

Family and domain databases

InterProiView protein in InterPro
IPR008516 Na/K-Atpase_Interacting
PANTHERiPTHR13084 PTHR13084, 1 hit
PfamiView protein in Pfam
PF05640 NKAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNKAI1_MOUSE
AccessioniPrimary (citable) accession number: Q9D035
Secondary accession number(s): A6MHP4, Q9D0Q6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: September 12, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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