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Protein

Single-stranded DNA-binding protein 3

Gene

Ssbp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Single-stranded DNA-binding protein 3
Alternative name(s):
Lck-associated signal transducer
Sequence-specific single-stranded-DNA-binding protein
Gene namesi
Name:Ssbp3
Synonyms:Last, Ssdp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1919725 Ssbp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001238291 – 388Single-stranded DNA-binding protein 3Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei155Asymmetric dimethylarginineBy similarity1
Modified residuei161Asymmetric dimethylarginineCombined sources1
Modified residuei165Asymmetric dimethylarginineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei352PhosphoserineBy similarity1
Modified residuei355PhosphoserineCombined sources1
Modified residuei360PhosphothreonineCombined sources1
Modified residuei381PhosphoserineBy similarity1
Modified residuei387PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ9D032
PRIDEiQ9D032

PTM databases

iPTMnetiQ9D032
PhosphoSitePlusiQ9D032

Expressioni

Gene expression databases

BgeeiENSMUSG00000061887 Expressed in 279 organ(s), highest expression level in dorsal pancreas
CleanExiMM_SSBP3
ExpressionAtlasiQ9D032 baseline and differential
GenevisibleiQ9D032 MM

Interactioni

Protein-protein interaction databases

BioGridi215389, 27 interactors
DIPiDIP-42843N
IntActiQ9D032, 2 interactors
MINTiQ9D032
STRINGi10090.ENSMUSP00000030367

Structurei

3D structure databases

ProteinModelPortaliQ9D032
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 48LisHPROSITE-ProRule annotationAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi98 – 319Pro-richAdd BLAST222
Compositional biasi158 – 369Gly-richAdd BLAST212

Phylogenomic databases

eggNOGiKOG4594 Eukaryota
ENOG410XPQX LUCA
GeneTreeiENSGT00390000009187
HOGENOMiHOG000037785
HOVERGENiHBG068487
InParanoidiQ9D032
OMAiHNPNSMM
OrthoDBiEOG091G111C
PhylomeDBiQ9D032
TreeFamiTF318961

Family and domain databases

InterProiView protein in InterPro
IPR006594 LisH
IPR008116 SSDP_DNA-bd
PRINTSiPR01743 SSDNABINDING
SMARTiView protein in SMART
SM00667 LisH, 1 hit
PROSITEiView protein in PROSITE
PS50896 LISH, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D032-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFAKGKGSAV PSDGQAREKL ALYVYEYLLH VGAQKSAQTF LSEIRWEKNI
60 70 80 90 100
TLGEPPGFLH SWWCVFWDLY CAAPERRDTC EHSSEAKAFH DYSAAAAPSP
110 120 130 140 150
VLGNIPPNDG MPGGPIPPGF FQGPPGSQPS PHAQPPPHNP SSMMGPHSQP
160 170 180 190 200
FMSPRYAGGP RPPIRMGNQP PGGVPGTQPL LPNSMDPTRQ QGHPNMGGSM
210 220 230 240 250
QRMNPPRGMG PMGPGPQNYG SGMRPPPNSL GPAMPGINMG PGAGRPWPNP
260 270 280 290 300
NSANSIPYSS SSPGTYVGPP GGGGPPGTPI MPSPADSTNS SDNIYTMINP
310 320 330 340 350
VPPGGSRSNF PMGPGSDGPM GGMGGMEPHH MNGSLGSGDI DGLPKNSPNN
360 370 380
ISGISNPPGT PRDDGELGGN FLHSFQNDNY SPSMTMSV
Length:388
Mass (Da):40,421
Last modified:January 16, 2004 - v2
Checksum:iDBBB169D4EE10536
GO
Isoform 2 (identifier: Q9D032-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-148: Missing.

Show »
Length:361
Mass (Da):37,697
Checksum:iCECDA59F18EFC0B2
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AS37B1AS37_MOUSE
Single-stranded DNA-binding protein...
Ssbp3
368Annotation score:
B1AS34B1AS34_MOUSE
Single-stranded DNA-binding protein...
Ssbp3
225Annotation score:
B1AS33B1AS33_MOUSE
Single-stranded DNA-binding protein...
Ssbp3
93Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti243A → D in AAG43403 (Ref. 1) Curated1
Sequence conflicti243A → V in BAB27882 (PubMed:16141072).Curated1
Sequence conflicti335L → V in AAG43403 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006262122 – 148Missing in isoform 2. 4 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170906 mRNA Translation: AAG43403.1
AF500117 mRNA Translation: AAM22102.1
AY167987 mRNA Translation: AAN87333.1
AK011853 mRNA Translation: BAB27882.1
BC003430 mRNA Translation: AAH03430.1
CCDSiCCDS18427.1 [Q9D032-1]
CCDS18428.1 [Q9D032-2]
RefSeqiNP_076161.2, NM_023672.2 [Q9D032-1]
NP_940840.1, NM_198438.1 [Q9D032-2]
UniGeneiMm.195635
Mm.445960
Mm.474861

Genome annotation databases

EnsembliENSMUST00000030367; ENSMUSP00000030367; ENSMUSG00000061887 [Q9D032-1]
ENSMUST00000072753; ENSMUSP00000072536; ENSMUSG00000061887 [Q9D032-2]
GeneIDi72475
KEGGimmu:72475
UCSCiuc008tyx.1 mouse [Q9D032-1]
uc008tyy.1 mouse [Q9D032-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170906 mRNA Translation: AAG43403.1
AF500117 mRNA Translation: AAM22102.1
AY167987 mRNA Translation: AAN87333.1
AK011853 mRNA Translation: BAB27882.1
BC003430 mRNA Translation: AAH03430.1
CCDSiCCDS18427.1 [Q9D032-1]
CCDS18428.1 [Q9D032-2]
RefSeqiNP_076161.2, NM_023672.2 [Q9D032-1]
NP_940840.1, NM_198438.1 [Q9D032-2]
UniGeneiMm.195635
Mm.445960
Mm.474861

3D structure databases

ProteinModelPortaliQ9D032
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215389, 27 interactors
DIPiDIP-42843N
IntActiQ9D032, 2 interactors
MINTiQ9D032
STRINGi10090.ENSMUSP00000030367

PTM databases

iPTMnetiQ9D032
PhosphoSitePlusiQ9D032

Proteomic databases

PaxDbiQ9D032
PRIDEiQ9D032

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030367; ENSMUSP00000030367; ENSMUSG00000061887 [Q9D032-1]
ENSMUST00000072753; ENSMUSP00000072536; ENSMUSG00000061887 [Q9D032-2]
GeneIDi72475
KEGGimmu:72475
UCSCiuc008tyx.1 mouse [Q9D032-1]
uc008tyy.1 mouse [Q9D032-2]

Organism-specific databases

CTDi23648
MGIiMGI:1919725 Ssbp3

Phylogenomic databases

eggNOGiKOG4594 Eukaryota
ENOG410XPQX LUCA
GeneTreeiENSGT00390000009187
HOGENOMiHOG000037785
HOVERGENiHBG068487
InParanoidiQ9D032
OMAiHNPNSMM
OrthoDBiEOG091G111C
PhylomeDBiQ9D032
TreeFamiTF318961

Miscellaneous databases

ChiTaRSiSsbp3 mouse
PROiPR:Q9D032
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061887 Expressed in 279 organ(s), highest expression level in dorsal pancreas
CleanExiMM_SSBP3
ExpressionAtlasiQ9D032 baseline and differential
GenevisibleiQ9D032 MM

Family and domain databases

InterProiView protein in InterPro
IPR006594 LisH
IPR008116 SSDP_DNA-bd
PRINTSiPR01743 SSDNABINDING
SMARTiView protein in SMART
SM00667 LisH, 1 hit
PROSITEiView protein in PROSITE
PS50896 LISH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSSBP3_MOUSE
AccessioniPrimary (citable) accession number: Q9D032
Secondary accession number(s): Q99LC6, Q9EQP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 16, 2004
Last modified: November 7, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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