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Protein

M-phase-specific PLK1-interacting protein

Gene

Mplkip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis.By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase-specific PLK1-interacting protein
Alternative name(s):
TTD non-photosensitive 1 protein homolog
Gene namesi
Name:Mplkip
Synonyms:Ttdn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1913558 Mplkip

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000656751 – 178M-phase-specific PLK1-interacting proteinAdd BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36Asymmetric dimethylarginineCombined sources1
Modified residuei39PhosphoserineBy similarity1
Modified residuei46PhosphoserineBy similarity1
Modified residuei50PhosphothreonineBy similarity1
Modified residuei56Omega-N-methylarginineBy similarity1
Modified residuei58Asymmetric dimethylarginineCombined sources1
Modified residuei67Asymmetric dimethylarginineCombined sources1
Modified residuei76Asymmetric dimethylarginineCombined sources1
Modified residuei79PhosphoserineBy similarity1
Modified residuei81PhosphoserineBy similarity1
Modified residuei92PhosphoserineBy similarity1
Modified residuei103PhosphoserineBy similarity1
Modified residuei114PhosphoserineBy similarity1
Modified residuei116Omega-N-methylarginineBy similarity1
Modified residuei119PhosphothreonineBy similarity1
Modified residuei123PhosphoserineBy similarity1
Modified residuei132PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated during mitosis in the cell cycle probably by CDK1.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ9D011
PaxDbiQ9D011
PRIDEiQ9D011

PTM databases

iPTMnetiQ9D011
PhosphoSitePlusiQ9D011

Expressioni

Gene expression databases

BgeeiENSMUSG00000012429 Expressed in 211 organ(s), highest expression level in embryo
CleanExiMM_2810021B07RIK
ExpressionAtlasiQ9D011 baseline and differential
GenevisibleiQ9D011 MM

Interactioni

Subunit structurei

Interacts with PLK1; phosphorylation-dependent.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059154

Structurei

3D structure databases

ProteinModelPortaliQ9D011
SMRiQ9D011
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J0XS Eukaryota
ENOG4111V2F LUCA
GeneTreeiENSGT00390000002582
HOGENOMiHOG000252982
HOVERGENiHBG073319
InParanoidiQ9D011
OMAiRMSNEVE
OrthoDBiEOG091G13KW
PhylomeDBiQ9D011
TreeFamiTF335586

Family and domain databases

InterProiView protein in InterPro
IPR026618 MPLKIP-like_vertebrate
IPR028265 TTDN1/SICKLE
PANTHERiPTHR22446 PTHR22446, 1 hit
PfamiView protein in Pfam
PF15502 MPLKIP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D011-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHRPNFRPPT PPYPSPGIGG WGGGNNFRGA LGGGPRPPSP RDGYGSPHHT
60 70 80 90 100
PPCGPRARPY GSSQSPRHGG NFSGARFGSP SPGGYPGSYS RSPAGSQHQF
110 120 130 140 150
GYSPGQQQTY PQGSPRTSTP FGSGRGREKR MSNELESYFK PSMLEDPWAG
160 170
LEPVSVVDIS QQYSNTQTFT GKKGRYFS
Length:178
Mass (Da):19,060
Last modified:June 1, 2001 - v1
Checksum:i0DA799EDEB988986
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VKT3A0A1Y7VKT3_MOUSE
M-phase-specific PLK1-interacting p...
Mplkip
48Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011919 mRNA Translation: BAB27916.1
AK030630 mRNA Translation: BAC27054.1
CCDSiCCDS26253.1
RefSeqiNP_079755.1, NM_025479.5
UniGeneiMm.291109
Mm.400463

Genome annotation databases

EnsembliENSMUST00000049744; ENSMUSP00000059154; ENSMUSG00000012429
GeneIDi66308
KEGGimmu:66308
UCSCiuc007poa.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011919 mRNA Translation: BAB27916.1
AK030630 mRNA Translation: BAC27054.1
CCDSiCCDS26253.1
RefSeqiNP_079755.1, NM_025479.5
UniGeneiMm.291109
Mm.400463

3D structure databases

ProteinModelPortaliQ9D011
SMRiQ9D011
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059154

PTM databases

iPTMnetiQ9D011
PhosphoSitePlusiQ9D011

Proteomic databases

MaxQBiQ9D011
PaxDbiQ9D011
PRIDEiQ9D011

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049744; ENSMUSP00000059154; ENSMUSG00000012429
GeneIDi66308
KEGGimmu:66308
UCSCiuc007poa.1 mouse

Organism-specific databases

CTDi136647
MGIiMGI:1913558 Mplkip

Phylogenomic databases

eggNOGiENOG410J0XS Eukaryota
ENOG4111V2F LUCA
GeneTreeiENSGT00390000002582
HOGENOMiHOG000252982
HOVERGENiHBG073319
InParanoidiQ9D011
OMAiRMSNEVE
OrthoDBiEOG091G13KW
PhylomeDBiQ9D011
TreeFamiTF335586

Miscellaneous databases

PROiPR:Q9D011
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000012429 Expressed in 211 organ(s), highest expression level in embryo
CleanExiMM_2810021B07RIK
ExpressionAtlasiQ9D011 baseline and differential
GenevisibleiQ9D011 MM

Family and domain databases

InterProiView protein in InterPro
IPR026618 MPLKIP-like_vertebrate
IPR028265 TTDN1/SICKLE
PANTHERiPTHR22446 PTHR22446, 1 hit
PfamiView protein in Pfam
PF15502 MPLKIP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMPLKI_MOUSE
AccessioniPrimary (citable) accession number: Q9D011
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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