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Protein

Elongator complex protein 3

Gene

Elp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in acetylation of alpha-tubulin (By similarity). May also have a methyltransferase activity. Involved in cell migration. Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:19185337).By similarity2 Publications

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi99Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi109Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi112Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1

GO - Molecular functioni

GO - Biological processi

  • central nervous system development Source: UniProtKB
  • neuron migration Source: UniProtKB
  • positive regulation of cell migration Source: UniProtKB
  • regulation of transcription by RNA polymerase II Source: UniProtKB
  • tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation Source: GO_Central

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processNeurogenesis, Transcription, Transcription regulation
LigandIron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 3 (EC:2.3.1.48)
Gene namesi
Name:Elp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1921445 Elp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002839871 – 547Elongator complex protein 3Add BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei161PhosphoserineCombined sources1
Modified residuei229N6-methyllysineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9CZX0
PaxDbiQ9CZX0
PeptideAtlasiQ9CZX0
PRIDEiQ9CZX0

PTM databases

iPTMnetiQ9CZX0
PhosphoSitePlusiQ9CZX0

Expressioni

Gene expression databases

BgeeiENSMUSG00000022031 Expressed in 282 organ(s), highest expression level in cerebral cortex
CleanExiMM_ELP3
ExpressionAtlasiQ9CZX0 baseline and differential
GenevisibleiQ9CZX0 MM

Interactioni

Subunit structurei

Component of the RNA polymerase II elongator complex (Elongator), which consists of ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6. ELP1, STIP1/ELP2 and ELP3 form the Elongator core complex. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with ELP1 (By similarity). Interacts with alpha-tubulin (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi216566, 1 interactor
IntActiQ9CZX0, 1 interactor
MINTiQ9CZX0
STRINGi10090.ENSMUSP00000022609

Structurei

3D structure databases

ProteinModelPortaliQ9CZX0
SMRiQ9CZX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini396 – 547N-acetyltransferasePROSITE-ProRule annotationAdd BLAST152

Sequence similaritiesi

Belongs to the ELP3 family.Curated

Phylogenomic databases

eggNOGiKOG2535 Eukaryota
COG1243 LUCA
GeneTreeiENSGT00390000013141
HOGENOMiHOG000227514
HOVERGENiHBG107845
InParanoidiQ9CZX0
KOiK07739
OMAiSYTGKEP
OrthoDBiEOG091G03ZS
PhylomeDBiQ9CZX0
TreeFamiTF105752

Family and domain databases

Gene3Di3.80.30.20, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR039661 ELP3
IPR034687 ELP3-like
IPR006638 Elp3/MiaB/NifB
IPR000182 GNAT_dom
IPR032432 Radical_SAM_C
IPR007197 rSAM
IPR023404 rSAM_horseshoe
PANTHERiPTHR11135 PTHR11135, 1 hit
PTHR11135:SF0 PTHR11135:SF0, 1 hit
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
PF04055 Radical_SAM, 1 hit
PF16199 Radical_SAM_C, 1 hit
PIRSFiPIRSF005669 Hist_AcTrfase_ELP3, 1 hit
SFLDiSFLDF00344 ELP3-like, 1 hit
SFLDG01086 elongater_protein-like, 1 hit
SFLDS00029 Radical_SAM, 1 hit
SMARTiView protein in SMART
SM00729 Elp3, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
TIGRFAMsiTIGR01211 ELP3, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9CZX0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRQKRKGDLS PAELMMLTIG DVIKQLVEAH EQGKDVDLNK MKTKTAAKYG
60 70 80 90 100
LASQPRLVDI IAAVPPHYRK ILIPKLKAKP VRTASGIAVV AVMCKPHRCP
110 120 130 140 150
HISFTGNICI YCPGGPDSDF EYSTQSYTGY EPTSMRAIRA RYDPFLQTRH
160 170 180 190 200
RIEQLKQLGH SVDKVEFIVM GGTFMALPEE YRDYFIRSLH DALSGHTSNN
210 220 230 240 250
IHEAIKYSER SFTKCVGITI ETRPDYCMKR HLSDMLTYGC TRLEIGVQSV
260 270 280 290 300
YEDVARDTNR GHTVKAACES FHLAKDSGFK VVTHMMPDLP NVGLERDIEQ
310 320 330 340 350
FIEFFENPAF RPDGLKLYPT LVIRGTGLYE LWKSGRYRSY SPSDLIELVA
360 370 380 390 400
RILALVPPWT RVYRVQRDIP MPLVSSGVEH GNLRELAFAR MKDLGIQCRD
410 420 430 440 450
VRTREVGIQE IHHRVRPYQV ELVRRDYVAN GGWETFLSYE DPDQDILIGL
460 470 480 490 500
LRLRKCSEET FRFELGGGVS IVRELHVYGS VVPVSSRDPT KFQHQGFGML
510 520 530 540
LMEEAERIAR EEHGSGKMAV ISGVGTRNYY RKIGYRLQGP YMVKMLK
Length:547
Mass (Da):62,385
Last modified:June 1, 2001 - v1
Checksum:i9234BB4DDD145FF4
GO
Isoform 2 (identifier: Q9CZX0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     7-7: G → GAKYVGQGRKGGSGFSEITG

Show »
Length:566
Mass (Da):64,266
Checksum:i2FF7F992FFFB3EC6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YDB8A0A286YDB8_MOUSE
Elongator complex protein 3
Elp3
553Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0244087G → GAKYVGQGRKGGSGFSEITG in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012072 mRNA Translation: BAB28009.1
AK088457 mRNA Translation: BAC40364.1
BC026461 mRNA Translation: AAH26461.1
BC057453 mRNA Translation: AAH57453.1
CCDSiCCDS56965.1 [Q9CZX0-2]
RefSeqiNP_001240741.1, NM_001253812.1 [Q9CZX0-2]
NP_083087.1, NM_028811.3 [Q9CZX0-1]
UniGeneiMm.29719
Mm.474894

Genome annotation databases

EnsembliENSMUST00000022609; ENSMUSP00000022609; ENSMUSG00000022031 [Q9CZX0-2]
ENSMUST00000225355; ENSMUSP00000153462; ENSMUSG00000022031 [Q9CZX0-1]
GeneIDi74195
KEGGimmu:74195
UCSCiuc007ujk.2 mouse [Q9CZX0-1]
uc007ujl.2 mouse [Q9CZX0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012072 mRNA Translation: BAB28009.1
AK088457 mRNA Translation: BAC40364.1
BC026461 mRNA Translation: AAH26461.1
BC057453 mRNA Translation: AAH57453.1
CCDSiCCDS56965.1 [Q9CZX0-2]
RefSeqiNP_001240741.1, NM_001253812.1 [Q9CZX0-2]
NP_083087.1, NM_028811.3 [Q9CZX0-1]
UniGeneiMm.29719
Mm.474894

3D structure databases

ProteinModelPortaliQ9CZX0
SMRiQ9CZX0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216566, 1 interactor
IntActiQ9CZX0, 1 interactor
MINTiQ9CZX0
STRINGi10090.ENSMUSP00000022609

PTM databases

iPTMnetiQ9CZX0
PhosphoSitePlusiQ9CZX0

Proteomic databases

EPDiQ9CZX0
PaxDbiQ9CZX0
PeptideAtlasiQ9CZX0
PRIDEiQ9CZX0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022609; ENSMUSP00000022609; ENSMUSG00000022031 [Q9CZX0-2]
ENSMUST00000225355; ENSMUSP00000153462; ENSMUSG00000022031 [Q9CZX0-1]
GeneIDi74195
KEGGimmu:74195
UCSCiuc007ujk.2 mouse [Q9CZX0-1]
uc007ujl.2 mouse [Q9CZX0-2]

Organism-specific databases

CTDi55140
MGIiMGI:1921445 Elp3

Phylogenomic databases

eggNOGiKOG2535 Eukaryota
COG1243 LUCA
GeneTreeiENSGT00390000013141
HOGENOMiHOG000227514
HOVERGENiHBG107845
InParanoidiQ9CZX0
KOiK07739
OMAiSYTGKEP
OrthoDBiEOG091G03ZS
PhylomeDBiQ9CZX0
TreeFamiTF105752

Miscellaneous databases

PROiPR:Q9CZX0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022031 Expressed in 282 organ(s), highest expression level in cerebral cortex
CleanExiMM_ELP3
ExpressionAtlasiQ9CZX0 baseline and differential
GenevisibleiQ9CZX0 MM

Family and domain databases

Gene3Di3.80.30.20, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR039661 ELP3
IPR034687 ELP3-like
IPR006638 Elp3/MiaB/NifB
IPR000182 GNAT_dom
IPR032432 Radical_SAM_C
IPR007197 rSAM
IPR023404 rSAM_horseshoe
PANTHERiPTHR11135 PTHR11135, 1 hit
PTHR11135:SF0 PTHR11135:SF0, 1 hit
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
PF04055 Radical_SAM, 1 hit
PF16199 Radical_SAM_C, 1 hit
PIRSFiPIRSF005669 Hist_AcTrfase_ELP3, 1 hit
SFLDiSFLDF00344 ELP3-like, 1 hit
SFLDG01086 elongater_protein-like, 1 hit
SFLDS00029 Radical_SAM, 1 hit
SMARTiView protein in SMART
SM00729 Elp3, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
TIGRFAMsiTIGR01211 ELP3, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiELP3_MOUSE
AccessioniPrimary (citable) accession number: Q9CZX0
Secondary accession number(s): Q8C2K2, Q8R369
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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