UniProtKB - Q9CZW5 (TOM70_MOUSE)
Protein
Mitochondrial import receptor subunit TOM70
Gene
Tomm70
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor that accelerates the import of all mitochondrial precursor proteins.By similarity
GO - Biological processi
- negative regulation of cell growth involved in cardiac muscle cell development Source: MGI
- positive regulation of protein import Source: MGI
Enzyme and pathway databases
Reactomei | R-MMU-5205685 Pink/Parkin Mediated Mitophagy R-MMU-5689880 Ub-specific processing proteases |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial import receptor subunit TOM70Alternative name(s): Mitochondrial precursor proteins import receptor Translocase of outer membrane 70 kDa subunit Translocase of outer mitochondrial membrane protein 70By similarity |
Gene namesi | Name:Tomm70By similarity Synonyms:D16Wsu109e, Tomm70a |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:106295 Tomm70a |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane By similarity; Single-pass membrane protein By similarity
Mitochondrion
- integral component of mitochondrial outer membrane Source: MGI
- mitochondrial outer membrane translocase complex Source: MGI
- mitochondrion Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 41 | Mitochondrial intermembraneSequence analysisAdd BLAST | 40 | |
Transmembranei | 42 – 62 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 63 – 611 | CytoplasmicSequence analysisAdd BLAST | 549 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion outer membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000106337 | 2 – 611 | Mitochondrial import receptor subunit TOM70Add BLAST | 610 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 74 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 94 | PhosphoserineCombined sources | 1 | |
Modified residuei | 99 | PhosphoserineCombined sources | 1 | |
Modified residuei | 105 | PhosphoserineBy similarity | 1 | |
Modified residuei | 108 | PhosphoserineCombined sources | 1 | |
Modified residuei | 113 | PhosphoserineBy similarity | 1 | |
Modified residuei | 188 | N6-acetyllysineBy similarity | 1 | |
Cross-linki | 278 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9CZW5 |
jPOSTi | Q9CZW5 |
MaxQBi | Q9CZW5 |
PaxDbi | Q9CZW5 |
PRIDEi | Q9CZW5 |
PTM databases
iPTMneti | Q9CZW5 |
PhosphoSitePlusi | Q9CZW5 |
SwissPalmi | Q9CZW5 |
Expressioni
Tissue specificityi
Expressed in the base region of the oxyntic and pyloric mucosae.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000022752 Expressed in 306 organ(s), highest expression level in caudate-putamen |
Genevisiblei | Q9CZW5 MM |
Interactioni
Subunit structurei
Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with CAPN8.1 Publication
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
Rgs13 | Q8K443 | 12 | EBI-642469,EBI-645999 |
Protein-protein interaction databases
BioGridi | 205817, 3 interactors |
IntActi | Q9CZW5, 5 interactors |
MINTi | Q9CZW5 |
STRINGi | 10090.ENSMUSP00000129186 |
Structurei
3D structure databases
ProteinModelPortali | Q9CZW5 |
SMRi | Q9CZW5 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 117 – 150 | TPR 1Add BLAST | 34 | |
Repeati | 156 – 189 | TPR 2Add BLAST | 34 | |
Repeati | 297 – 330 | TPR 3Add BLAST | 34 | |
Repeati | 332 – 365 | TPR 4Add BLAST | 34 | |
Repeati | 370 – 403 | TPR 5Add BLAST | 34 | |
Repeati | 404 – 437 | TPR 6Add BLAST | 34 | |
Repeati | 445 – 478 | TPR 7Add BLAST | 34 | |
Repeati | 479 – 512 | TPR 8Add BLAST | 34 | |
Repeati | 514 – 547 | TPR 9Add BLAST | 34 | |
Repeati | 548 – 581 | TPR 10Add BLAST | 34 |
Sequence similaritiesi
Belongs to the Tom70 family.Curated
Keywords - Domaini
Repeat, TPR repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0547 Eukaryota ENOG410YVNZ LUCA |
GeneTreei | ENSGT00940000157095 |
HOVERGENi | HBG062335 |
InParanoidi | Q9CZW5 |
KOi | K17768 |
OMAi | WKQDLDK |
OrthoDBi | 303136at2759 |
TreeFami | TF106203 |
Family and domain databases
Gene3Di | 1.25.40.10, 2 hits |
InterProi | View protein in InterPro IPR013026 TPR-contain_dom IPR011990 TPR-like_helical_dom_sf IPR001440 TPR_1 IPR019734 TPR_repeat |
Pfami | View protein in Pfam PF00515 TPR_1, 1 hit PF13181 TPR_8, 3 hits |
SMARTi | View protein in SMART SM00028 TPR, 10 hits |
SUPFAMi | SSF48452 SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005 TPR, 7 hits PS50293 TPR_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9CZW5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAASKPIEAA MAAAAAPGSG NGVGGGGGTA GPGSGAGTLP RWHVALAIGA
60 70 80 90 100
PLLLGAGAMY LWSRRRRRRE AGGRGDASGL KRNSERKTPE GRASPALGSG
110 120 130 140 150
HHDGSGDSLE MSSLDRAQAA KNKGNKYFKA GKYEQAIQCY TEAISLCPTE
160 170 180 190 200
KNVDLSTFYQ NRAAAFEQLQ KWKEVAQDCT KAVELNPKYV KALFRRAKAH
210 220 230 240 250
EKLDNKKECL EDVTAVCILE GFQNEQSMLL ADKVLKLLGK ENAKEKYKNR
260 270 280 290 300
EPLMPSPQFI KSYFSSFTDD IISQPMLKGE KSDEDKDKEG EALEVKENSG
310 320 330 340 350
YLKAKQYMEE ENYDKIISEC SKEIDAQGKY MAEALLLRAT FYLLIGSANA
360 370 380 390 400
AKPDLDKVIS LKEANVKLRA NALIKRGTMC MQQQQPMLST QDFNMAAEID
410 420 430 440 450
PMNSDVYHHR GQLKILLDLV EEAVADFDAC IRLRPKFALA QAQKCFALYR
460 470 480 490 500
QAYTANNSSQ VQAAMKGFEE IIKKFPRCAE GYALYAQALT DQQQFGKADE
510 520 530 540 550
MYDKCIDLEP DNATTYVHKG LLQLQWKQDL DKGLELISKA IEIDNKCDFA
560 570 580 590 600
YETMGTIEVQ RGNMEKAIDM FNKAINLAKS EMEMAHLYSL CDAAHAQTEV
610
AKKYGLKPPT L
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 116 | R → S in BAB28018 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK012084 mRNA Translation: BAB28018.1 AK083586 mRNA Translation: BAC38960.1 AK145458 mRNA Translation: BAE26448.1 AK150429 mRNA Translation: BAE29552.1 BC057096 mRNA Translation: AAH57096.1 BC139420 mRNA Translation: AAI39421.1 BC139421 mRNA Translation: AAI39422.1 |
CCDSi | CCDS28227.1 |
RefSeqi | NP_613065.2, NM_138599.5 |
UniGenei | Mm.196933 Mm.213292 |
Genome annotation databases
Ensembli | ENSMUST00000166897; ENSMUSP00000129186; ENSMUSG00000022752 |
GeneIDi | 28185 |
KEGGi | mmu:28185 |
UCSCi | uc007zmz.1 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK012084 mRNA Translation: BAB28018.1 AK083586 mRNA Translation: BAC38960.1 AK145458 mRNA Translation: BAE26448.1 AK150429 mRNA Translation: BAE29552.1 BC057096 mRNA Translation: AAH57096.1 BC139420 mRNA Translation: AAI39421.1 BC139421 mRNA Translation: AAI39422.1 |
CCDSi | CCDS28227.1 |
RefSeqi | NP_613065.2, NM_138599.5 |
UniGenei | Mm.196933 Mm.213292 |
3D structure databases
ProteinModelPortali | Q9CZW5 |
SMRi | Q9CZW5 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 205817, 3 interactors |
IntActi | Q9CZW5, 5 interactors |
MINTi | Q9CZW5 |
STRINGi | 10090.ENSMUSP00000129186 |
PTM databases
iPTMneti | Q9CZW5 |
PhosphoSitePlusi | Q9CZW5 |
SwissPalmi | Q9CZW5 |
Proteomic databases
EPDi | Q9CZW5 |
jPOSTi | Q9CZW5 |
MaxQBi | Q9CZW5 |
PaxDbi | Q9CZW5 |
PRIDEi | Q9CZW5 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000166897; ENSMUSP00000129186; ENSMUSG00000022752 |
GeneIDi | 28185 |
KEGGi | mmu:28185 |
UCSCi | uc007zmz.1 mouse |
Organism-specific databases
CTDi | 28185 |
MGIi | MGI:106295 Tomm70a |
Phylogenomic databases
eggNOGi | KOG0547 Eukaryota ENOG410YVNZ LUCA |
GeneTreei | ENSGT00940000157095 |
HOVERGENi | HBG062335 |
InParanoidi | Q9CZW5 |
KOi | K17768 |
OMAi | WKQDLDK |
OrthoDBi | 303136at2759 |
TreeFami | TF106203 |
Enzyme and pathway databases
Reactomei | R-MMU-5205685 Pink/Parkin Mediated Mitophagy R-MMU-5689880 Ub-specific processing proteases |
Miscellaneous databases
ChiTaRSi | Tomm70a mouse |
PROi | PR:Q9CZW5 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022752 Expressed in 306 organ(s), highest expression level in caudate-putamen |
Genevisiblei | Q9CZW5 MM |
Family and domain databases
Gene3Di | 1.25.40.10, 2 hits |
InterProi | View protein in InterPro IPR013026 TPR-contain_dom IPR011990 TPR-like_helical_dom_sf IPR001440 TPR_1 IPR019734 TPR_repeat |
Pfami | View protein in Pfam PF00515 TPR_1, 1 hit PF13181 TPR_8, 3 hits |
SMARTi | View protein in SMART SM00028 TPR, 10 hits |
SUPFAMi | SSF48452 SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005 TPR, 7 hits PS50293 TPR_REGION, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | TOM70_MOUSE | |
Accessioni | Q9CZW5Primary (citable) accession number: Q9CZW5 Secondary accession number(s): Q8BNI6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 2001 |
Last sequence update: | July 27, 2011 | |
Last modified: | January 16, 2019 | |
This is version 157 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot