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Protein

Mitochondrial import receptor subunit TOM70

Gene

Tomm70

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor that accelerates the import of all mitochondrial precursor proteins.By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-5205685 Pink/Parkin Mediated Mitophagy
R-MMU-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM70
Alternative name(s):
Mitochondrial precursor proteins import receptor
Translocase of outer membrane 70 kDa subunit
Translocase of outer mitochondrial membrane protein 70By similarity
Gene namesi
Name:Tomm70By similarity
Synonyms:D16Wsu109e, Tomm70a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:106295 Tomm70a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 41Mitochondrial intermembraneSequence analysisAdd BLAST40
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 611CytoplasmicSequence analysisAdd BLAST549

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001063372 – 611Mitochondrial import receptor subunit TOM70Add BLAST610

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei74Omega-N-methylarginineBy similarity1
Modified residuei94PhosphoserineCombined sources1
Modified residuei99PhosphoserineCombined sources1
Modified residuei105PhosphoserineBy similarity1
Modified residuei108PhosphoserineCombined sources1
Modified residuei113PhosphoserineBy similarity1
Modified residuei188N6-acetyllysineBy similarity1
Cross-linki278Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CZW5
MaxQBiQ9CZW5
PaxDbiQ9CZW5
PRIDEiQ9CZW5

PTM databases

iPTMnetiQ9CZW5
PhosphoSitePlusiQ9CZW5
SwissPalmiQ9CZW5

Expressioni

Tissue specificityi

Expressed in the base region of the oxyntic and pyloric mucosae.1 Publication

Gene expression databases

BgeeiENSMUSG00000022752 Expressed in 306 organ(s), highest expression level in caudate-putamen
GenevisibleiQ9CZW5 MM

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with CAPN8.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Rgs13Q8K44312EBI-642469,EBI-645999

Protein-protein interaction databases

BioGridi205817, 3 interactors
IntActiQ9CZW5, 5 interactors
MINTiQ9CZW5
STRINGi10090.ENSMUSP00000129186

Structurei

3D structure databases

ProteinModelPortaliQ9CZW5
SMRiQ9CZW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati117 – 150TPR 1Add BLAST34
Repeati156 – 189TPR 2Add BLAST34
Repeati297 – 330TPR 3Add BLAST34
Repeati332 – 365TPR 4Add BLAST34
Repeati370 – 403TPR 5Add BLAST34
Repeati404 – 437TPR 6Add BLAST34
Repeati445 – 478TPR 7Add BLAST34
Repeati479 – 512TPR 8Add BLAST34
Repeati514 – 547TPR 9Add BLAST34
Repeati548 – 581TPR 10Add BLAST34

Sequence similaritiesi

Belongs to the Tom70 family.Curated

Keywords - Domaini

Repeat, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0547 Eukaryota
ENOG410YVNZ LUCA
GeneTreeiENSGT00900000140844
HOVERGENiHBG062335
InParanoidiQ9CZW5
KOiK17768
OMAiWKQDLDK
OrthoDBiEOG091G0CYZ
TreeFamiTF106203

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00515 TPR_1, 1 hit
PF13181 TPR_8, 3 hits
SMARTiView protein in SMART
SM00028 TPR, 10 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 7 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CZW5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASKPIEAA MAAAAAPGSG NGVGGGGGTA GPGSGAGTLP RWHVALAIGA
60 70 80 90 100
PLLLGAGAMY LWSRRRRRRE AGGRGDASGL KRNSERKTPE GRASPALGSG
110 120 130 140 150
HHDGSGDSLE MSSLDRAQAA KNKGNKYFKA GKYEQAIQCY TEAISLCPTE
160 170 180 190 200
KNVDLSTFYQ NRAAAFEQLQ KWKEVAQDCT KAVELNPKYV KALFRRAKAH
210 220 230 240 250
EKLDNKKECL EDVTAVCILE GFQNEQSMLL ADKVLKLLGK ENAKEKYKNR
260 270 280 290 300
EPLMPSPQFI KSYFSSFTDD IISQPMLKGE KSDEDKDKEG EALEVKENSG
310 320 330 340 350
YLKAKQYMEE ENYDKIISEC SKEIDAQGKY MAEALLLRAT FYLLIGSANA
360 370 380 390 400
AKPDLDKVIS LKEANVKLRA NALIKRGTMC MQQQQPMLST QDFNMAAEID
410 420 430 440 450
PMNSDVYHHR GQLKILLDLV EEAVADFDAC IRLRPKFALA QAQKCFALYR
460 470 480 490 500
QAYTANNSSQ VQAAMKGFEE IIKKFPRCAE GYALYAQALT DQQQFGKADE
510 520 530 540 550
MYDKCIDLEP DNATTYVHKG LLQLQWKQDL DKGLELISKA IEIDNKCDFA
560 570 580 590 600
YETMGTIEVQ RGNMEKAIDM FNKAINLAKS EMEMAHLYSL CDAAHAQTEV
610
AKKYGLKPPT L
Length:611
Mass (Da):67,590
Last modified:July 27, 2011 - v2
Checksum:i5103C658D8BF9C53
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116R → S in BAB28018 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012084 mRNA Translation: BAB28018.1
AK083586 mRNA Translation: BAC38960.1
AK145458 mRNA Translation: BAE26448.1
AK150429 mRNA Translation: BAE29552.1
BC057096 mRNA Translation: AAH57096.1
BC139420 mRNA Translation: AAI39421.1
BC139421 mRNA Translation: AAI39422.1
CCDSiCCDS28227.1
RefSeqiNP_613065.2, NM_138599.5
UniGeneiMm.196933
Mm.213292

Genome annotation databases

EnsembliENSMUST00000166897; ENSMUSP00000129186; ENSMUSG00000022752
GeneIDi28185
KEGGimmu:28185
UCSCiuc007zmz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012084 mRNA Translation: BAB28018.1
AK083586 mRNA Translation: BAC38960.1
AK145458 mRNA Translation: BAE26448.1
AK150429 mRNA Translation: BAE29552.1
BC057096 mRNA Translation: AAH57096.1
BC139420 mRNA Translation: AAI39421.1
BC139421 mRNA Translation: AAI39422.1
CCDSiCCDS28227.1
RefSeqiNP_613065.2, NM_138599.5
UniGeneiMm.196933
Mm.213292

3D structure databases

ProteinModelPortaliQ9CZW5
SMRiQ9CZW5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205817, 3 interactors
IntActiQ9CZW5, 5 interactors
MINTiQ9CZW5
STRINGi10090.ENSMUSP00000129186

PTM databases

iPTMnetiQ9CZW5
PhosphoSitePlusiQ9CZW5
SwissPalmiQ9CZW5

Proteomic databases

EPDiQ9CZW5
MaxQBiQ9CZW5
PaxDbiQ9CZW5
PRIDEiQ9CZW5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000166897; ENSMUSP00000129186; ENSMUSG00000022752
GeneIDi28185
KEGGimmu:28185
UCSCiuc007zmz.1 mouse

Organism-specific databases

CTDi28185
MGIiMGI:106295 Tomm70a

Phylogenomic databases

eggNOGiKOG0547 Eukaryota
ENOG410YVNZ LUCA
GeneTreeiENSGT00900000140844
HOVERGENiHBG062335
InParanoidiQ9CZW5
KOiK17768
OMAiWKQDLDK
OrthoDBiEOG091G0CYZ
TreeFamiTF106203

Enzyme and pathway databases

ReactomeiR-MMU-5205685 Pink/Parkin Mediated Mitophagy
R-MMU-5689880 Ub-specific processing proteases

Miscellaneous databases

ChiTaRSiTomm70a mouse
PROiPR:Q9CZW5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022752 Expressed in 306 organ(s), highest expression level in caudate-putamen
GenevisibleiQ9CZW5 MM

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00515 TPR_1, 1 hit
PF13181 TPR_8, 3 hits
SMARTiView protein in SMART
SM00028 TPR, 10 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 7 hits
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTOM70_MOUSE
AccessioniPrimary (citable) accession number: Q9CZW5
Secondary accession number(s): Q8BNI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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