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Protein

Ras-related protein Rab-3B

Gene

Rab3b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 37GTPBy similarity9
Nucleotide bindingi48 – 54GTPBy similarity7
Nucleotide bindingi77 – 81GTPBy similarity5
Nucleotide bindingi135 – 138GTPBy similarity4
Nucleotide bindingi165 – 167GTPBy similarity3

GO - Molecular functioni

  • GDP binding Source: MGI
  • GTPase activity Source: MGI
  • GTP binding Source: UniProtKB-KW
  • GTP-dependent protein binding Source: MGI
  • myosin V binding Source: MGI

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-3B
Gene namesi
Name:Rab3b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1917158 Rab3b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001210822 – 219Ras-related protein Rab-3BAdd BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei188PhosphoserineBy similarity1
Modified residuei190PhosphoserineBy similarity1
Lipidationi217S-geranylgeranyl cysteineBy similarity1
Modified residuei219Cysteine methyl esterBy similarity1
Lipidationi219S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiQ9CZT8
PaxDbiQ9CZT8
PRIDEiQ9CZT8

PTM databases

iPTMnetiQ9CZT8
PhosphoSitePlusiQ9CZT8

Expressioni

Tissue specificityi

Abundantly expressed in testis, lung and brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000003411 Expressed in 152 organ(s), highest expression level in olfactory bulb
CleanExiMM_RAB3B
ExpressionAtlasiQ9CZT8 baseline and differential
GenevisibleiQ9CZT8 MM

Interactioni

Subunit structurei

Interacts with RIMS1, RIMS2, RPH3A and RPH3AL (PubMed:12578829). The GTP-bound form interacts with GAS8/DRC4 (via coiled-coil domains) (PubMed:18396146).2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213749, 9 interactors
IntActiQ9CZT8, 10 interactors
MINTiQ9CZT8
STRINGi10090.ENSMUSP00000003502

Structurei

3D structure databases

ProteinModelPortaliQ9CZT8
SMRiQ9CZT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi51 – 59Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0093 Eukaryota
ENOG410ZZXQ LUCA
GeneTreeiENSGT00890000139330
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ9CZT8
KOiK06108
OMAiSQQNCSC
TreeFamiTF313199

Family and domain databases

CDDicd01865 Rab3, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR037872 Rab3
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CZT8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASVTDGKTG IKDASDQNFD YMFKLLIIGN SSVGKTSFLF RYADDTFTPA
60 70 80 90 100
FVSTVGIDFK VKTVYRHEKR VKLQIWDTAG QERYRTITTA YYRGAMGFIL
110 120 130 140 150
MYDITNEESF NAVQDWATQI KTYSWDNAQV ILVGNKCDME EERVVPTEKG
160 170 180 190 200
RLLAEQLGFD FFEASAKENI SVRQAFERLV DAICDKMSDS MDTDPSVLGA
210
SKTTRLSDTP PLLQQNCSC
Length:219
Mass (Da):24,757
Last modified:June 1, 2001 - v1
Checksum:i494B3A0686D325C8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A7Z6A2A7Z6_MOUSE
Ras-related protein Rab-3B
Rab3b
228Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312036 mRNA Translation: AAG60046.1
AF307514 Genomic DNA Translation: AAL09395.1
AK012165 mRNA Translation: BAB28071.1
AK082959 mRNA Translation: BAC38710.1
BC051918 mRNA Translation: AAH51918.2
BC057173 mRNA Translation: AAH57173.1
CCDSiCCDS18459.1
RefSeqiNP_076026.1, NM_023537.5
UniGeneiMm.41580

Genome annotation databases

EnsembliENSMUST00000003502; ENSMUSP00000003502; ENSMUSG00000003411
ENSMUST00000106650; ENSMUSP00000102261; ENSMUSG00000003411
GeneIDi69908
KEGGimmu:69908
UCSCiuc008ubu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312036 mRNA Translation: AAG60046.1
AF307514 Genomic DNA Translation: AAL09395.1
AK012165 mRNA Translation: BAB28071.1
AK082959 mRNA Translation: BAC38710.1
BC051918 mRNA Translation: AAH51918.2
BC057173 mRNA Translation: AAH57173.1
CCDSiCCDS18459.1
RefSeqiNP_076026.1, NM_023537.5
UniGeneiMm.41580

3D structure databases

ProteinModelPortaliQ9CZT8
SMRiQ9CZT8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213749, 9 interactors
IntActiQ9CZT8, 10 interactors
MINTiQ9CZT8
STRINGi10090.ENSMUSP00000003502

PTM databases

iPTMnetiQ9CZT8
PhosphoSitePlusiQ9CZT8

Proteomic databases

MaxQBiQ9CZT8
PaxDbiQ9CZT8
PRIDEiQ9CZT8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003502; ENSMUSP00000003502; ENSMUSG00000003411
ENSMUST00000106650; ENSMUSP00000102261; ENSMUSG00000003411
GeneIDi69908
KEGGimmu:69908
UCSCiuc008ubu.1 mouse

Organism-specific databases

CTDi5865
MGIiMGI:1917158 Rab3b

Phylogenomic databases

eggNOGiKOG0093 Eukaryota
ENOG410ZZXQ LUCA
GeneTreeiENSGT00890000139330
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ9CZT8
KOiK06108
OMAiSQQNCSC
TreeFamiTF313199

Enzyme and pathway databases

ReactomeiR-MMU-8873719 RAB geranylgeranylation

Miscellaneous databases

PROiPR:Q9CZT8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003411 Expressed in 152 organ(s), highest expression level in olfactory bulb
CleanExiMM_RAB3B
ExpressionAtlasiQ9CZT8 baseline and differential
GenevisibleiQ9CZT8 MM

Family and domain databases

CDDicd01865 Rab3, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR037872 Rab3
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB3B_MOUSE
AccessioniPrimary (citable) accession number: Q9CZT8
Secondary accession number(s): Q80WV9, Q920F1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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