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Protein

Elongation factor Ts, mitochondrial

Gene

Tsfm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.UniRule annotation

GO - Molecular functioni

  • translation elongation factor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor Ts, mitochondrialUniRule annotation
Short name:
EF-TsUniRule annotation
Short name:
EF-TsMtUniRule annotation
Gene namesi
Name:Tsfm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1913649 Tsfm

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 44MitochondrionUniRule annotationAdd BLAST44
ChainiPRO_000000746945 – 324Elongation factor Ts, mitochondrialAdd BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75N6-succinyllysineCombined sources1
Modified residuei132N6-succinyllysineCombined sources1
Modified residuei191N6-succinyllysineCombined sources1
Modified residuei269PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CZR8
MaxQBiQ9CZR8
PaxDbiQ9CZR8
PRIDEiQ9CZR8

PTM databases

iPTMnetiQ9CZR8
PhosphoSitePlusiQ9CZR8
SwissPalmiQ9CZR8

Expressioni

Gene expression databases

BgeeiENSMUSG00000040521 Expressed in 253 organ(s), highest expression level in camera-type eye
CleanExiMM_TSFM
ExpressionAtlasiQ9CZR8 baseline and differential
GenevisibleiQ9CZR8 MM

Interactioni

Protein-protein interaction databases

IntActiQ9CZR8, 1 interactor
MINTiQ9CZR8
STRINGi10090.ENSMUSP00000042134

Structurei

3D structure databases

ProteinModelPortaliQ9CZR8
SMRiQ9CZR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EF-Ts family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1071 Eukaryota
COG0264 LUCA
GeneTreeiENSGT00390000016293
HOGENOMiHOG000220988
HOVERGENiHBG005571
InParanoidiQ9CZR8
KOiK02357
OMAiGYTFANC
OrthoDBiEOG091G0E11
PhylomeDBiQ9CZR8
TreeFamiTF314154

Family and domain databases

Gene3Di3.30.479.20, 2 hits
HAMAPiMF_00050 EF_Ts, 1 hit
InterProiView protein in InterPro
IPR036402 EF-Ts_dimer_sf
IPR001816 Transl_elong_EFTs/EF1B
IPR014039 Transl_elong_EFTs/EF1B_dimer
IPR018101 Transl_elong_Ts_CS
IPR009060 UBA-like_sf
PANTHERiPTHR11741 PTHR11741, 1 hit
PfamiView protein in Pfam
PF00889 EF_TS, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF54713 SSF54713, 2 hits
PROSITEiView protein in PROSITE
PS01126 EF_TS_1, 1 hit
PS01127 EF_TS_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9CZR8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLLRSLRFF PVACTGRSAR AVLLQPSQPW LTFHAGPSLS SAASSKELLM
60 70 80 90 100
KLRRKTGYSF VNCKKALETC GGDLKQAEDW LHKQAQKEGW SKAAKLHGRK
110 120 130 140 150
TKEGLIGLLQ EGNTAVLVEV NCETDFVSRN LKFQQLVQQV ALGTMAHCQN
160 170 180 190 200
LTDRLSTYSK GFLNSSELSE LAAGPDREGS LKDQLALAIG KLGENMILKR
210 220 230 240 250
AAWVKVPSGF YVGSYVHGVT QSPSLQNLVL GKYGALVICE TPEQIANLEE
260 270 280 290 300
VGRRLGQHVV GMAPLSVGSL DDEPGGETET RMLPQPYLLD PSITLGQYVQ
310 320
PQGVTVVDFV RFECGEDEQV AEAE
Length:324
Mass (Da):35,334
Last modified:June 1, 2001 - v1
Checksum:i6E8AFA409F62791F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9CX33Q9CX33_MOUSE
Elongation factor Ts, mitochondrial
Tsfm TSFM
193Annotation score:
D3Z4M7D3Z4M7_MOUSE
Elongation factor Ts, mitochondrial
Tsfm
206Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012240 mRNA Translation: BAB28113.1
AK169164 mRNA Translation: BAE40943.1
BC057904 mRNA Translation: AAH57904.1
CCDSiCCDS24222.1
RefSeqiNP_079813.1, NM_025537.3
UniGeneiMm.29900

Genome annotation databases

EnsembliENSMUST00000040560; ENSMUSP00000042134; ENSMUSG00000040521
GeneIDi66399
KEGGimmu:66399
UCSCiuc007hhm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012240 mRNA Translation: BAB28113.1
AK169164 mRNA Translation: BAE40943.1
BC057904 mRNA Translation: AAH57904.1
CCDSiCCDS24222.1
RefSeqiNP_079813.1, NM_025537.3
UniGeneiMm.29900

3D structure databases

ProteinModelPortaliQ9CZR8
SMRiQ9CZR8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CZR8, 1 interactor
MINTiQ9CZR8
STRINGi10090.ENSMUSP00000042134

PTM databases

iPTMnetiQ9CZR8
PhosphoSitePlusiQ9CZR8
SwissPalmiQ9CZR8

Proteomic databases

EPDiQ9CZR8
MaxQBiQ9CZR8
PaxDbiQ9CZR8
PRIDEiQ9CZR8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040560; ENSMUSP00000042134; ENSMUSG00000040521
GeneIDi66399
KEGGimmu:66399
UCSCiuc007hhm.1 mouse

Organism-specific databases

CTDi10102
MGIiMGI:1913649 Tsfm

Phylogenomic databases

eggNOGiKOG1071 Eukaryota
COG0264 LUCA
GeneTreeiENSGT00390000016293
HOGENOMiHOG000220988
HOVERGENiHBG005571
InParanoidiQ9CZR8
KOiK02357
OMAiGYTFANC
OrthoDBiEOG091G0E11
PhylomeDBiQ9CZR8
TreeFamiTF314154

Miscellaneous databases

ChiTaRSiTsfm mouse
PROiPR:Q9CZR8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040521 Expressed in 253 organ(s), highest expression level in camera-type eye
CleanExiMM_TSFM
ExpressionAtlasiQ9CZR8 baseline and differential
GenevisibleiQ9CZR8 MM

Family and domain databases

Gene3Di3.30.479.20, 2 hits
HAMAPiMF_00050 EF_Ts, 1 hit
InterProiView protein in InterPro
IPR036402 EF-Ts_dimer_sf
IPR001816 Transl_elong_EFTs/EF1B
IPR014039 Transl_elong_EFTs/EF1B_dimer
IPR018101 Transl_elong_Ts_CS
IPR009060 UBA-like_sf
PANTHERiPTHR11741 PTHR11741, 1 hit
PfamiView protein in Pfam
PF00889 EF_TS, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF54713 SSF54713, 2 hits
PROSITEiView protein in PROSITE
PS01126 EF_TS_1, 1 hit
PS01127 EF_TS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEFTS_MOUSE
AccessioniPrimary (citable) accession number: Q9CZR8
Secondary accession number(s): Q3TFF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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