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Protein

Mitochondrial import receptor subunit TOM40B

Gene

Tomm40l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential channel-forming protein implicated in import of protein precursors into mitochondria.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPorin
Biological processIon transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM40B
Alternative name(s):
Protein TOMM40-like
Gene namesi
Name:Tomm40l
Synonyms:Tomm40b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3589112 Tomm40l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000515371 – 308Mitochondrial import receptor subunit TOM40BAdd BLAST308

Proteomic databases

MaxQBiQ9CZR3
PaxDbiQ9CZR3
PRIDEiQ9CZR3

PTM databases

iPTMnetiQ9CZR3
PhosphoSitePlusiQ9CZR3

Expressioni

Gene expression databases

BgeeiENSMUSG00000005674 Expressed in 267 organ(s), highest expression level in heart left ventricle
ExpressionAtlasiQ9CZR3 baseline and differential
GenevisibleiQ9CZR3 MM

Interactioni

Subunit structurei

Forms part of the preprotein translocase of the outer mitochondrial membrane (TOM complex) containing TOMM22, TOMM40, TOMM40L and TOMM70. Interacts with mitochondrial targeting sequences (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005817

Structurei

3D structure databases

ProteinModelPortaliQ9CZR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni281 – 308Required for mitochondrial targetingBy similarityAdd BLAST28

Sequence similaritiesi

Belongs to the Tom40 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3296 Eukaryota
ENOG410XS2U LUCA
GeneTreeiENSGT00390000003308
HOGENOMiHOG000007440
HOVERGENiHBG054707
InParanoidiQ9CZR3
KOiK11518
OMAiIEGVKMI
OrthoDBiEOG091G0MNA
PhylomeDBiQ9CZR3
TreeFamiTF106204

Family and domain databases

CDDicd07305 Porin3_Tom40, 1 hit
Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR023614 Porin_dom_sf
IPR027246 Porin_Euk/Tom40
IPR037930 Tom40
PANTHERiPTHR10802 PTHR10802, 1 hit
PfamiView protein in Pfam
PF01459 Porin_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9CZR3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNTLGLAPM GTLPRRSHRR EEPLPNPGSF DELHRLCKDV FPAQMEGVKL
60 70 80 90 100
VVNKVLSSHF QVAHTVHMSA LGLPGYHLHT AYAGDWQLSP TEVFPTVVGD
110 120 130 140 150
MDSSGSLNAQ VLLLLAERLR AKAVFQTQQA KFLTWQFDGE YRGDDYTATL
160 170 180 190 200
TLGNPDLIGE SVIMVAHFLQ SITHRLVLGG ELVYHRRPGE EGAILTLAGK
210 220 230 240 250
YSAVHWVATL NVGSGGAHAS YYHKANEQVQ VGVEFEANTR LQDTTFSFGY
260 270 280 290 300
HLTLPQADMV FRGLVDSNWC VGAVLEKKMR PLPVTLALGA FLNHWRNRFH

CGFSITVG
Length:308
Mass (Da):34,005
Last modified:June 1, 2001 - v1
Checksum:i413D66AED372D967
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YXS8D3YXS8_MOUSE
Mitochondrial import receptor subun...
Tomm40l
274Annotation score:
D3Z346D3Z346_MOUSE
Mitochondrial import receptor subun...
Tomm40l
95Annotation score:
D3YY29D3YY29_MOUSE
Mitochondrial import receptor subun...
Tomm40l
118Annotation score:
M0QWR6M0QWR6_MOUSE
Mitochondrial import receptor subun...
Tomm40l
49Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012264 mRNA Translation: BAB28127.1
AK028388 mRNA Translation: BAC25924.1
BC058978 mRNA Translation: AAH58978.1
CCDSiCCDS15481.1
RefSeqiNP_001032247.1, NM_001037170.2
XP_006497016.1, XM_006496953.3
UniGeneiMm.288374

Genome annotation databases

EnsembliENSMUST00000005817; ENSMUSP00000005817; ENSMUSG00000005674
ENSMUST00000111327; ENSMUSP00000106959; ENSMUSG00000005674
GeneIDi641376
KEGGimmu:641376
UCSCiuc007dni.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012264 mRNA Translation: BAB28127.1
AK028388 mRNA Translation: BAC25924.1
BC058978 mRNA Translation: AAH58978.1
CCDSiCCDS15481.1
RefSeqiNP_001032247.1, NM_001037170.2
XP_006497016.1, XM_006496953.3
UniGeneiMm.288374

3D structure databases

ProteinModelPortaliQ9CZR3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005817

PTM databases

iPTMnetiQ9CZR3
PhosphoSitePlusiQ9CZR3

Proteomic databases

MaxQBiQ9CZR3
PaxDbiQ9CZR3
PRIDEiQ9CZR3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005817; ENSMUSP00000005817; ENSMUSG00000005674
ENSMUST00000111327; ENSMUSP00000106959; ENSMUSG00000005674
GeneIDi641376
KEGGimmu:641376
UCSCiuc007dni.1 mouse

Organism-specific databases

CTDi84134
MGIiMGI:3589112 Tomm40l

Phylogenomic databases

eggNOGiKOG3296 Eukaryota
ENOG410XS2U LUCA
GeneTreeiENSGT00390000003308
HOGENOMiHOG000007440
HOVERGENiHBG054707
InParanoidiQ9CZR3
KOiK11518
OMAiIEGVKMI
OrthoDBiEOG091G0MNA
PhylomeDBiQ9CZR3
TreeFamiTF106204

Miscellaneous databases

ChiTaRSiTomm40l mouse
PROiPR:Q9CZR3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005674 Expressed in 267 organ(s), highest expression level in heart left ventricle
ExpressionAtlasiQ9CZR3 baseline and differential
GenevisibleiQ9CZR3 MM

Family and domain databases

CDDicd07305 Porin3_Tom40, 1 hit
Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR023614 Porin_dom_sf
IPR027246 Porin_Euk/Tom40
IPR037930 Tom40
PANTHERiPTHR10802 PTHR10802, 1 hit
PfamiView protein in Pfam
PF01459 Porin_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM40L_MOUSE
AccessioniPrimary (citable) accession number: Q9CZR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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