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Protein

Bardet-Biedl syndrome 5 protein homolog

Gene

Bbs5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-5620922 BBSome-mediated cargo-targeting to cilium

Names & Taxonomyi

Protein namesi
Recommended name:
Bardet-Biedl syndrome 5 protein homolog
Gene namesi
Name:Bbs5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1919819 Bbs5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002232561 – 341Bardet-Biedl syndrome 5 protein homologAdd BLAST341

Proteomic databases

MaxQBiQ9CZQ9
PaxDbiQ9CZQ9
PRIDEiQ9CZQ9

PTM databases

PhosphoSitePlusiQ9CZQ9

Expressioni

Gene expression databases

BgeeiENSMUSG00000063145
CleanExiMM_BBS5
ExpressionAtlasiQ9CZQ9 baseline and differential
GenevisibleiQ9CZQ9 MM

Interactioni

Subunit structurei

PPart of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Binds to phosphoinositides. Interacts with CCDC28B. Interacts with SMO; the interaction is indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO. Interacts with PKD1 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-1909 BBSome complex
IntActiQ9CZQ9, 5 interactors
STRINGi10090.ENSMUSP00000074494

Structurei

3D structure databases

ProteinModelPortaliQ9CZQ9
SMRiQ9CZQ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BBS5 family.Curated

Phylogenomic databases

eggNOGiENOG410IGWS Eukaryota
ENOG410XUMT LUCA
GeneTreeiENSGT00390000002753
HOGENOMiHOG000231964
HOVERGENiHBG053449
InParanoidiQ9CZQ9
KOiK16748
OMAiIIWHSLV
OrthoDBiEOG091G0C3Y
PhylomeDBiQ9CZQ9
TreeFamiTF106129

Family and domain databases

InterProiView protein in InterPro
IPR006606 BBL5
IPR030804 BBS5/fem-3
IPR014003 DM16_repeat
PANTHERiPTHR21351 PTHR21351, 1 hit
PfamiView protein in Pfam
PF07289 BBL5, 1 hit
PIRSFiPIRSF010072 DUF1448, 1 hit
SMARTiView protein in SMART
SM00683 DM16, 2 hits

Sequencei

Sequence statusi: Complete.

Q9CZQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLDVLWED RDVRFDVSSQ QMKTRPGEVL IDCLDSIEDT KGNNGDRGRL
60 70 80 90 100
LVTNLRIIWH SLALPRVNLS IGYNCILNIT TRTANSKLRG QTEALYILTK
110 120 130 140 150
CNTTRFEFIF TNLVPGSPRL FTSVIAVHRA YETSKMYRDF KLRSAVIQNK
160 170 180 190 200
QLRLLPQEHV YDKINGVWNL SSDQGNLGTF FITNVRIVWH ANMNDSFNVS
210 220 230 240 250
IPYLQIRSIK IRDSKFGLAL VIESSQQSGG YVLGFKIDPV EKLQESVKEI
260 270 280 290 300
NSLHKVYSAS PIFGVNYEME EKPQPLEALT VEQIQDDVEI DSDDHTDAFV
310 320 330 340
AYFADGNKQQ DREPVFSEEL GLAIEKLKDG FTLQGLWEVM S
Length:341
Mass (Da):38,862
Last modified:June 1, 2001 - v1
Checksum:i8FD2BF5943F72325
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012283 mRNA Translation: BAB28141.1
AL929083 Genomic DNA No translation available.
BC061031 mRNA Translation: AAH61031.1
CCDSiCCDS16094.1
RefSeqiNP_082560.1, NM_028284.2
UniGeneiMm.252136

Genome annotation databases

EnsembliENSMUST00000074963; ENSMUSP00000074494; ENSMUSG00000063145
GeneIDi72569
KEGGimmu:72569
UCSCiuc008jyf.1 mouse

Similar proteinsi

Entry informationi

Entry nameiBBS5_MOUSE
AccessioniPrimary (citable) accession number: Q9CZQ9
Secondary accession number(s): A2AUC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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