UniProtKB - Q9CZP7 (CD37L_MOUSE)
Protein
Hsp90 co-chaperone Cdc37-like 1
Gene
Cdc37l1
Organism
Mus musculus (Mouse)
Status
Functioni
Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90.By similarity
GO - Molecular functioni
- chaperone binding Source: GO_Central
- heat shock protein binding Source: GO_Central
- unfolded protein binding Source: GO_Central
GO - Biological processi
- protein folding Source: GO_Central
- protein stabilization Source: GO_Central
Keywordsi
Molecular function | Chaperone |
Enzyme and pathway databases
Reactomei | R-MMU-114608, Platelet degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Hsp90 co-chaperone Cdc37-like 1 |
Gene namesi | Name:Cdc37l1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1914322, Cdc37l1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000318522 | 1 – 335 | Hsp90 co-chaperone Cdc37-like 1Add BLAST | 335 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 32 | PhosphoserineBy similarity | 1 | |
Modified residuei | 88 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9CZP7 |
PeptideAtlasi | Q9CZP7 |
PRIDEi | Q9CZP7 |
PTM databases
iPTMneti | Q9CZP7 |
PhosphoSitePlusi | Q9CZP7 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000024780, Expressed in interventricular septum and 277 other tissues |
ExpressionAtlasi | Q9CZP7, baseline and differential |
Genevisiblei | Q9CZP7, MM |
Interactioni
Subunit structurei
Self-associates. Forms complexes with Hsp70 and Hsp90.
Interacts with CDC37, FKBP4, PPID and STIP1.
By similarityGO - Molecular functioni
- chaperone binding Source: GO_Central
- heat shock protein binding Source: GO_Central
- unfolded protein binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 211919, 8 interactors |
STRINGi | 10090.ENSMUSP00000060421 |
Miscellaneous databases
RNActi | Q9CZP7, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 170 | Self-associationBy similarityAdd BLAST | 169 | |
Regioni | 147 – 276 | Self-association and interaction with Hsp90By similarityAdd BLAST | 130 | |
Regioni | 266 – 335 | Interaction with Hsp70By similarityAdd BLAST | 70 | |
Regioni | 277 – 335 | Required for interaction with STIP1By similarityAdd BLAST | 59 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 84 – 120 | Sequence analysisAdd BLAST | 37 |
Sequence similaritiesi
Belongs to the CDC37 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2260, Eukaryota |
GeneTreei | ENSGT00390000013443 |
HOGENOMi | CLU_046495_1_0_1 |
InParanoidi | Q9CZP7 |
OMAi | CLWNVDA |
OrthoDBi | 786744at2759 |
PhylomeDBi | Q9CZP7 |
TreeFami | TF101059 |
Family and domain databases
Gene3Di | 1.20.58.610, 1 hit |
InterProi | View protein in InterPro IPR004918, Cdc37 IPR013874, Cdc37_Hsp90-bd IPR038189, Cdc37_Hsp90-bd_sf |
PANTHERi | PTHR12800, PTHR12800, 1 hit |
Pfami | View protein in Pfam PF08565, CDC37_M, 1 hit |
SMARTi | View protein in SMART SM01070, CDC37_M, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9CZP7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEQPWPPPGP WSFPRTGGET EEESDLDVSP SSSHYSPVPD GGAQMYSHGI
60 70 80 90 100
ELACQKQKEF VKSSVACKWN LAEAQQKLGS LALHNSESLD QEHAKAQTAV
110 120 130 140 150
SELRQREEEW RQKEEALVQR ERMCLWNMDA ISKDVFNKSF INQDKRKTEE
160 170 180 190 200
EDKSQSFMQK YEQKIRHFGM LSRWDDSQRF LSDHPHLVCE ETAKYLILWC
210 220 230 240 250
FHLEAEQKGA LMEQIAHQAV VMQFIMEMAK NCNVDPRGCF RLFFQKAKAE
260 270 280 290 300
EEGYFEAFKN ELEAFKSRVR LYAQSQSLQP VTVQNHVPHS GVGCIGSLES
310 320 330
LPQNPDSLQC CTPAPLCSVD SVVHKEDDDR MMDTV
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A286YCB4 | A0A286YCB4_MOUSE | Hsp90 co-chaperone Cdc37-like 1 | Cdc37l1 | 263 | Annotation score: | ||
A0A286YCM9 | A0A286YCM9_MOUSE | Hsp90 co-chaperone Cdc37-like 1 | Cdc37l1 | 113 | Annotation score: | ||
A0A286YD64 | A0A286YD64_MOUSE | Hsp90 co-chaperone Cdc37-like 1 | Cdc37l1 | 56 | Annotation score: | ||
A0A286YDH0 | A0A286YDH0_MOUSE | Hsp90 co-chaperone Cdc37-like 1 | Cdc37l1 | 63 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 144 | D → G in BAB31410 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031213 | 304 – 312 | NPDSLQCCT → FSFLEAHRN in isoform 4. 1 Publication | 9 | |
Alternative sequenceiVSP_031214 | 304 – 310 | NPDSLQC → VSWKRGY in isoform 3. 1 Publication | 7 | |
Alternative sequenceiVSP_031215 | 304 – 307 | NPDS → APRF in isoform 2. 1 Publication | 4 | |
Alternative sequenceiVSP_031216 | 308 – 335 | Missing in isoform 2. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_031217 | 311 – 335 | Missing in isoform 3. 1 PublicationAdd BLAST | 25 | |
Alternative sequenceiVSP_031218 | 313 – 335 | Missing in isoform 4. 1 PublicationAdd BLAST | 23 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK012312 mRNA Translation: BAB28158.1 AK018787 mRNA Translation: BAB31410.1 AK044291 mRNA Translation: BAC31858.1 AK048044 mRNA Translation: BAC33220.1 AK078468 mRNA Translation: BAC37289.1 AK079556 mRNA Translation: BAE43368.1 AK165398 mRNA Translation: BAE38162.1 BC031761 mRNA Translation: AAH31761.1 |
CCDSi | CCDS29729.1 [Q9CZP7-1] CCDS89371.1 [Q9CZP7-2] CCDS89372.1 [Q9CZP7-4] |
RefSeqi | NP_001289309.1, NM_001302380.1 [Q9CZP7-4] NP_001289311.1, NM_001302382.1 [Q9CZP7-2] NP_001289372.1, NM_001302443.1 NP_080226.1, NM_025950.3 [Q9CZP7-1] |
Genome annotation databases
Ensembli | ENSMUST00000050148; ENSMUSP00000060421; ENSMUSG00000024780 [Q9CZP7-1] ENSMUST00000224511; ENSMUSP00000152985; ENSMUSG00000024780 [Q9CZP7-4] ENSMUST00000225210; ENSMUSP00000153424; ENSMUSG00000024780 [Q9CZP7-3] ENSMUST00000225310; ENSMUSP00000153192; ENSMUSG00000024780 [Q9CZP7-2] |
GeneIDi | 67072 |
KEGGi | mmu:67072 |
UCSCi | uc008hcs.2, mouse [Q9CZP7-1] uc008hct.2, mouse [Q9CZP7-3] uc008hcu.2, mouse [Q9CZP7-2] uc008hcw.2, mouse [Q9CZP7-4] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK012312 mRNA Translation: BAB28158.1 AK018787 mRNA Translation: BAB31410.1 AK044291 mRNA Translation: BAC31858.1 AK048044 mRNA Translation: BAC33220.1 AK078468 mRNA Translation: BAC37289.1 AK079556 mRNA Translation: BAE43368.1 AK165398 mRNA Translation: BAE38162.1 BC031761 mRNA Translation: AAH31761.1 |
CCDSi | CCDS29729.1 [Q9CZP7-1] CCDS89371.1 [Q9CZP7-2] CCDS89372.1 [Q9CZP7-4] |
RefSeqi | NP_001289309.1, NM_001302380.1 [Q9CZP7-4] NP_001289311.1, NM_001302382.1 [Q9CZP7-2] NP_001289372.1, NM_001302443.1 NP_080226.1, NM_025950.3 [Q9CZP7-1] |
3D structure databases
SMRi | Q9CZP7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 211919, 8 interactors |
STRINGi | 10090.ENSMUSP00000060421 |
PTM databases
iPTMneti | Q9CZP7 |
PhosphoSitePlusi | Q9CZP7 |
Proteomic databases
PaxDbi | Q9CZP7 |
PeptideAtlasi | Q9CZP7 |
PRIDEi | Q9CZP7 |
Protocols and materials databases
Antibodypediai | 24046, 193 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000050148; ENSMUSP00000060421; ENSMUSG00000024780 [Q9CZP7-1] ENSMUST00000224511; ENSMUSP00000152985; ENSMUSG00000024780 [Q9CZP7-4] ENSMUST00000225210; ENSMUSP00000153424; ENSMUSG00000024780 [Q9CZP7-3] ENSMUST00000225310; ENSMUSP00000153192; ENSMUSG00000024780 [Q9CZP7-2] |
GeneIDi | 67072 |
KEGGi | mmu:67072 |
UCSCi | uc008hcs.2, mouse [Q9CZP7-1] uc008hct.2, mouse [Q9CZP7-3] uc008hcu.2, mouse [Q9CZP7-2] uc008hcw.2, mouse [Q9CZP7-4] |
Organism-specific databases
CTDi | 55664 |
MGIi | MGI:1914322, Cdc37l1 |
Phylogenomic databases
eggNOGi | KOG2260, Eukaryota |
GeneTreei | ENSGT00390000013443 |
HOGENOMi | CLU_046495_1_0_1 |
InParanoidi | Q9CZP7 |
OMAi | CLWNVDA |
OrthoDBi | 786744at2759 |
PhylomeDBi | Q9CZP7 |
TreeFami | TF101059 |
Enzyme and pathway databases
Reactomei | R-MMU-114608, Platelet degranulation |
Miscellaneous databases
BioGRID-ORCSi | 67072, 1 hit in 17 CRISPR screens |
ChiTaRSi | Cdc37l1, mouse |
PROi | PR:Q9CZP7 |
RNActi | Q9CZP7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024780, Expressed in interventricular septum and 277 other tissues |
ExpressionAtlasi | Q9CZP7, baseline and differential |
Genevisiblei | Q9CZP7, MM |
Family and domain databases
Gene3Di | 1.20.58.610, 1 hit |
InterProi | View protein in InterPro IPR004918, Cdc37 IPR013874, Cdc37_Hsp90-bd IPR038189, Cdc37_Hsp90-bd_sf |
PANTHERi | PTHR12800, PTHR12800, 1 hit |
Pfami | View protein in Pfam PF08565, CDC37_M, 1 hit |
SMARTi | View protein in SMART SM01070, CDC37_M, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CD37L_MOUSE | |
Accessioni | Q9CZP7Primary (citable) accession number: Q9CZP7 Secondary accession number(s): Q3TNC7 Q9CU15 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families