Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calcium-activated potassium channel subunit beta-2

Gene

Kcnmb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1296052 Ca2+ activated K+ channels

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-activated potassium channel subunit beta-2
Alternative name(s):
BK channel subunit beta-2
Short name:
BKbeta2
Calcium-activated potassium channel, subfamily M subunit beta-2
Charybdotoxin receptor subunit beta-2
K(VCA)beta-2
Maxi K channel subunit beta-2
Slo-beta-2
Gene namesi
Name:Kcnmb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1919663 Kcnmb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 46CytoplasmicSequence analysisAdd BLAST46
Transmembranei47 – 67Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini68 – 194ExtracellularSequence analysisAdd BLAST127
Transmembranei195 – 215Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini216 – 235CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001870521 – 235Calcium-activated potassium channel subunit beta-2Add BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9CZM9
PRIDEiQ9CZM9

PTM databases

PhosphoSitePlusiQ9CZM9

Expressioni

Gene expression databases

BgeeiENSMUSG00000037610 Expressed in 102 organ(s), highest expression level in trigeminal ganglion
ExpressionAtlasiQ9CZM9 baseline and differential
GenevisibleiQ9CZM9 MM

Interactioni

Subunit structurei

Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB2 per KCNMA1 tetramer (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112531

Structurei

3D structure databases

ProteinModelPortaliQ9CZM9
SMRiQ9CZM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 45Ball and chainAdd BLAST45

Domaini

The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of KCNMA1 channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues 20-45) linking it to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a well ordered loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its C-terminus (By similarity).By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEU4 Eukaryota
ENOG4111FIG LUCA
GeneTreeiENSGT00390000015997
HOGENOMiHOG000290180
HOVERGENiHBG052223
InParanoidiQ9CZM9
KOiK04938
OMAiKMFIWTS
OrthoDBiEOG091G0MVO
PhylomeDBiQ9CZM9
TreeFamiTF328589

Family and domain databases

Gene3Di4.10.81.20, 1 hit
InterProiView protein in InterPro
IPR003930 K_chnl_Ca-activ_BK_bsu
IPR037096 KCNMB2_ball/chain_dom_sf
IPR015382 KCNMB2_ball_chain_dom
PANTHERiPTHR10258 PTHR10258, 1 hit
PfamiView protein in Pfam
PF03185 CaKB, 1 hit
PF09303 KcnmB2_inactiv, 1 hit
PRINTSiPR01450 BKCHANNELB

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9CZM9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFIWTSGRTS SSYRQDEKRN IYQKIRDHDL LDKRKTVTAL KAGEDRAILL
60 70 80 90 100
GLAMMVCSIM MYFLLGITLL RSYMQSVWTE EAQCALLNVS ITETFNCSFS
110 120 130 140 150
CGPDCWKLSQ YPCLQVYVNL TSSGERLLLY HTEETMKINQ KCSYIPKCGN
160 170 180 190 200
NFEESMSLVS VVMENFRRHQ HFPCYSDPEG NQKSVILTKL YSSNVLFHSL
210 220 230
FWPTCMMAGG VAIVAMVKLT QYLSLLCERI QRINR
Length:235
Mass (Da):27,120
Last modified:June 1, 2001 - v1
Checksum:iF87D3D91C22BBDF2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YXE4A0A0A6YXE4_MOUSE
Calcium-activated potassium channel...
Kcnmb2
181Annotation score:
B5BNW2B5BNW2_MOUSE
Calcium-activated potassium channel...
Kcnmb2 KCNMB2
36Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY062429 mRNA Translation: AAL38982.1
AK012400 mRNA Translation: BAB28216.1
BC046227 mRNA Translation: AAH46227.1
BC058957 mRNA Translation: AAH58957.1
CCDSiCCDS17292.1
RefSeqiNP_082507.1, NM_028231.2
XP_006535612.1, XM_006535549.3
XP_006535613.1, XM_006535550.1
XP_006535614.1, XM_006535551.3
XP_017175231.1, XM_017319742.1
UniGeneiMm.64790

Genome annotation databases

EnsembliENSMUST00000119310; ENSMUSP00000112531; ENSMUSG00000037610
ENSMUST00000119970; ENSMUSP00000113234; ENSMUSG00000037610
ENSMUST00000178668; ENSMUSP00000136596; ENSMUSG00000037610
ENSMUST00000192429; ENSMUSP00000141656; ENSMUSG00000037610
GeneIDi72413
KEGGimmu:72413
UCSCiuc008owa.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY062429 mRNA Translation: AAL38982.1
AK012400 mRNA Translation: BAB28216.1
BC046227 mRNA Translation: AAH46227.1
BC058957 mRNA Translation: AAH58957.1
CCDSiCCDS17292.1
RefSeqiNP_082507.1, NM_028231.2
XP_006535612.1, XM_006535549.3
XP_006535613.1, XM_006535550.1
XP_006535614.1, XM_006535551.3
XP_017175231.1, XM_017319742.1
UniGeneiMm.64790

3D structure databases

ProteinModelPortaliQ9CZM9
SMRiQ9CZM9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112531

PTM databases

PhosphoSitePlusiQ9CZM9

Proteomic databases

PaxDbiQ9CZM9
PRIDEiQ9CZM9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000119310; ENSMUSP00000112531; ENSMUSG00000037610
ENSMUST00000119970; ENSMUSP00000113234; ENSMUSG00000037610
ENSMUST00000178668; ENSMUSP00000136596; ENSMUSG00000037610
ENSMUST00000192429; ENSMUSP00000141656; ENSMUSG00000037610
GeneIDi72413
KEGGimmu:72413
UCSCiuc008owa.1 mouse

Organism-specific databases

CTDi10242
MGIiMGI:1919663 Kcnmb2

Phylogenomic databases

eggNOGiENOG410IEU4 Eukaryota
ENOG4111FIG LUCA
GeneTreeiENSGT00390000015997
HOGENOMiHOG000290180
HOVERGENiHBG052223
InParanoidiQ9CZM9
KOiK04938
OMAiKMFIWTS
OrthoDBiEOG091G0MVO
PhylomeDBiQ9CZM9
TreeFamiTF328589

Enzyme and pathway databases

ReactomeiR-MMU-1296052 Ca2+ activated K+ channels

Miscellaneous databases

PROiPR:Q9CZM9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037610 Expressed in 102 organ(s), highest expression level in trigeminal ganglion
ExpressionAtlasiQ9CZM9 baseline and differential
GenevisibleiQ9CZM9 MM

Family and domain databases

Gene3Di4.10.81.20, 1 hit
InterProiView protein in InterPro
IPR003930 K_chnl_Ca-activ_BK_bsu
IPR037096 KCNMB2_ball/chain_dom_sf
IPR015382 KCNMB2_ball_chain_dom
PANTHERiPTHR10258 PTHR10258, 1 hit
PfamiView protein in Pfam
PF03185 CaKB, 1 hit
PF09303 KcnmB2_inactiv, 1 hit
PRINTSiPR01450 BKCHANNELB
ProtoNetiSearch...

Entry informationi

Entry nameiKCMB2_MOUSE
AccessioniPrimary (citable) accession number: Q9CZM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again