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Protein

Protein Mis18-alpha

Gene

Mis18a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi56ZincPROSITE-ProRule annotation1
Metal bindingi59ZincPROSITE-ProRule annotation1
Metal bindingi112ZincPROSITE-ProRule annotation1
Metal bindingi115ZincPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • CENP-A containing nucleosome assembly Source: MGI
  • chromosome segregation Source: MGI
  • regulation of DNA methylation Source: MGI

Keywordsi

Biological processCell cycle, Cell division, Mitosis
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Mis18-alpha
Gene namesi
Name:Mis18a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1913828 Mis18a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002784731 – 204Protein Mis18-alphaAdd BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineBy similarity1
Modified residuei16PhosphoserineBy similarity1
Modified residuei17PhosphoserineBy similarity1
Cross-linki133Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei204PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9CZJ6
PaxDbiQ9CZJ6
PRIDEiQ9CZJ6

PTM databases

iPTMnetiQ9CZJ6
PhosphoSitePlusiQ9CZJ6

Expressioni

Gene expression databases

BgeeiENSMUSG00000022978 Expressed in 285 organ(s), highest expression level in cumulus cell
CleanExiMM_2610039C10RIK
GenevisibleiQ9CZJ6 MM

Interactioni

Subunit structurei

Homodimer, and heterodimer with OIP5/MIS18B. Identified in a complex containing MIS18A, OIP5/MIS18B, MIS18BP1, RBBP7 and RBBP4.By similarity

Protein-protein interaction databases

ComplexPortaliCPX-3273 Mis18 complex
STRINGi10090.ENSMUSP00000097150

Structurei

3D structure databases

ProteinModelPortaliQ9CZJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 149Mis18PROSITE-ProRule annotationAdd BLAST99

Sequence similaritiesi

Belongs to the mis18 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IKYV Eukaryota
ENOG41125JV LUCA
GeneTreeiENSGT00390000009777
HOGENOMiHOG000059535
HOVERGENiHBG108147
InParanoidiQ9CZJ6
KOiK11564
OMAiWVASQED
OrthoDBiEOG091G0KM2
PhylomeDBiQ9CZJ6
TreeFamiTF333200

Family and domain databases

InterProiView protein in InterPro
IPR034752 Mis18
IPR004910 Yippee/Mis18/Cereblon
PfamiView protein in Pfam
PF03226 Yippee-Mis18, 1 hit
PROSITEiView protein in PROSITE
PS51793 MIS18, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CZJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSESPLLEK RLSEDSSRYL RLQKWANMSS ADALGLEKER PEEKAAAAEN
60 70 80 90 100
PLVFLCARCR RPLGDSLTWV ASQEDTNCIL LRSVSCNVSV DKEPKLSKCR
110 120 130 140 150
DEDGCILEAL YCTGCSLSLG YVYRCTPKNL DYKRDLFCLS VEAVESYTLG
160 170 180 190 200
SSEKQIVSED KELFNLESRV EIEKSIKQME EVLTALQKKL REVESKLSLA

SRGS
Length:204
Mass (Da):22,949
Last modified:June 1, 2001 - v1
Checksum:iBBD667250FDF9B0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012533 mRNA Translation: BAB28302.1
AK163310 mRNA Translation: BAE37292.1
BC079900 mRNA Translation: AAH79900.1
CCDSiCCDS28316.1
RefSeqiNP_079918.1, NM_025642.1
UniGeneiMm.180363

Genome annotation databases

EnsembliENSMUST00000099554; ENSMUSP00000097150; ENSMUSG00000022978
GeneIDi66578
KEGGimmu:66578
UCSCiuc007zwj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012533 mRNA Translation: BAB28302.1
AK163310 mRNA Translation: BAE37292.1
BC079900 mRNA Translation: AAH79900.1
CCDSiCCDS28316.1
RefSeqiNP_079918.1, NM_025642.1
UniGeneiMm.180363

3D structure databases

ProteinModelPortaliQ9CZJ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3273 Mis18 complex
STRINGi10090.ENSMUSP00000097150

PTM databases

iPTMnetiQ9CZJ6
PhosphoSitePlusiQ9CZJ6

Proteomic databases

MaxQBiQ9CZJ6
PaxDbiQ9CZJ6
PRIDEiQ9CZJ6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099554; ENSMUSP00000097150; ENSMUSG00000022978
GeneIDi66578
KEGGimmu:66578
UCSCiuc007zwj.1 mouse

Organism-specific databases

CTDi54069
MGIiMGI:1913828 Mis18a

Phylogenomic databases

eggNOGiENOG410IKYV Eukaryota
ENOG41125JV LUCA
GeneTreeiENSGT00390000009777
HOGENOMiHOG000059535
HOVERGENiHBG108147
InParanoidiQ9CZJ6
KOiK11564
OMAiWVASQED
OrthoDBiEOG091G0KM2
PhylomeDBiQ9CZJ6
TreeFamiTF333200

Enzyme and pathway databases

ReactomeiR-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere

Miscellaneous databases

PROiPR:Q9CZJ6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022978 Expressed in 285 organ(s), highest expression level in cumulus cell
CleanExiMM_2610039C10RIK
GenevisibleiQ9CZJ6 MM

Family and domain databases

InterProiView protein in InterPro
IPR034752 Mis18
IPR004910 Yippee/Mis18/Cereblon
PfamiView protein in Pfam
PF03226 Yippee-Mis18, 1 hit
PROSITEiView protein in PROSITE
PS51793 MIS18, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMS18A_MOUSE
AccessioniPrimary (citable) accession number: Q9CZJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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