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Protein

Zinc finger CCHC domain-containing protein 12

Gene

Zcchc12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri346 – 363CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 12
Alternative name(s):
Smad-interacting zinc finger protein 1
Gene namesi
Name:Zcchc12
Synonyms:Sizn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1919943 Zcchc12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001509721 – 402Zinc finger CCHC domain-containing protein 12Add BLAST402

Proteomic databases

MaxQBiQ9CZA5
PaxDbiQ9CZA5
PRIDEiQ9CZA5

PTM databases

PhosphoSitePlusiQ9CZA5

Expressioni

Tissue specificityi

In embryonic brains expression is restricted to the ventral region of the forebrain, including the septum, amygdala, caudal putamen, and in the basal-forebrain cholinergic neurons. In adults, expressed in the brain, and at low levels in the testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000036699 Expressed in 194 organ(s), highest expression level in medial preoptic region
CleanExiMM_ZCCHC12
GenevisibleiQ9CZA5 MM

Interactioni

Subunit structurei

Interacts with SMAD1 and CREB-binding protein (CBP). Forms a protein-DNA complex through its association with SMAD1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044550

Structurei

3D structure databases

ProteinModelPortaliQ9CZA5
SMRiQ9CZA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi218 – 224Poly-Glu7

Sequence similaritiesi

Belongs to the ZCCHC12 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri346 – 363CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410J95G Eukaryota
ENOG4111945 LUCA
GeneTreeiENSGT00530000062986
HOGENOMiHOG000230940
HOVERGENiHBG073535
InParanoidiQ9CZA5
OMAiRSEPIME
OrthoDBiEOG091G0AM8
PhylomeDBiQ9CZA5
TreeFamiTF335054

Family and domain databases

InterProiView protein in InterPro
IPR026523 PNMA
IPR001878 Znf_CCHC
PANTHERiPTHR23095 PTHR23095, 1 hit
PfamiView protein in Pfam
PF14893 PNMA, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CZA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASILSRLGS SRGQNSPLPP WAHSMLRSLG RSLGPLMASM AERNMRLFSG
60 70 80 90 100
RAEPAQGEET FENWLSQVTG VLPDWHMPEE EKVRRLMRTL RGPAREVMRL
110 120 130 140 150
LQAANPGLDV EDFLRAMKLV FGESESSVTA HSKFVNTVQE HGEKPSLYVI
160 170 180 190 200
RLEVQLQNAI QAGVFAEREA NQARLHQLLV GAEMSTDLRF RLKNLLRVYA
210 220 230 240 250
NEPERLPNFL ELIRMIREEE EWEETFINPK RPRRAESVME RALSPMAFQS
260 270 280 290 300
SPPIMISSID CNVIEIDDSP DDSDEDVILV EPEDPPLPSS SASSFLGRAV
310 320 330 340 350
SEDQVLVIES PNIFEIQAPS TSSGAGRKNN RGFGELRRAR KRKHTIHCSH
360 370 380 390 400
CGEEGHSKET CDNESDKGQV FENLIITLQE LTHAEERARG APGEPIGLSE

PQ
Length:402
Mass (Da):45,107
Last modified:June 1, 2001 - v1
Checksum:i3603A26F2CCD5C3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY466375 mRNA Translation: AAR85891.1
AK012833 mRNA Translation: BAB28501.1
BC049071 mRNA Translation: AAH49071.1
BC055714 mRNA Translation: AAH55714.1
CCDSiCCDS30058.1
RefSeqiNP_082601.1, NM_028325.3
XP_006541458.1, XM_006541395.1
XP_006541460.1, XM_006541397.1
XP_006541461.1, XM_006541398.1
XP_006541462.1, XM_006541399.1
XP_006541463.1, XM_006541400.2
XP_006541464.1, XM_006541401.1
XP_006541466.1, XM_006541403.1
XP_011249276.1, XM_011250974.2
XP_017174118.1, XM_017318629.1
XP_017174119.1, XM_017318630.1
UniGeneiMm.297698

Genome annotation databases

EnsembliENSMUST00000048067; ENSMUSP00000044550; ENSMUSG00000036699
ENSMUST00000115256; ENSMUSP00000110911; ENSMUSG00000036699
ENSMUST00000115257; ENSMUSP00000110912; ENSMUSG00000036699
ENSMUST00000115258; ENSMUSP00000110913; ENSMUSG00000036699
GeneIDi72693
KEGGimmu:72693
UCSCiuc009sxk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY466375 mRNA Translation: AAR85891.1
AK012833 mRNA Translation: BAB28501.1
BC049071 mRNA Translation: AAH49071.1
BC055714 mRNA Translation: AAH55714.1
CCDSiCCDS30058.1
RefSeqiNP_082601.1, NM_028325.3
XP_006541458.1, XM_006541395.1
XP_006541460.1, XM_006541397.1
XP_006541461.1, XM_006541398.1
XP_006541462.1, XM_006541399.1
XP_006541463.1, XM_006541400.2
XP_006541464.1, XM_006541401.1
XP_006541466.1, XM_006541403.1
XP_011249276.1, XM_011250974.2
XP_017174118.1, XM_017318629.1
XP_017174119.1, XM_017318630.1
UniGeneiMm.297698

3D structure databases

ProteinModelPortaliQ9CZA5
SMRiQ9CZA5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044550

PTM databases

PhosphoSitePlusiQ9CZA5

Proteomic databases

MaxQBiQ9CZA5
PaxDbiQ9CZA5
PRIDEiQ9CZA5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048067; ENSMUSP00000044550; ENSMUSG00000036699
ENSMUST00000115256; ENSMUSP00000110911; ENSMUSG00000036699
ENSMUST00000115257; ENSMUSP00000110912; ENSMUSG00000036699
ENSMUST00000115258; ENSMUSP00000110913; ENSMUSG00000036699
GeneIDi72693
KEGGimmu:72693
UCSCiuc009sxk.2 mouse

Organism-specific databases

CTDi170261
MGIiMGI:1919943 Zcchc12

Phylogenomic databases

eggNOGiENOG410J95G Eukaryota
ENOG4111945 LUCA
GeneTreeiENSGT00530000062986
HOGENOMiHOG000230940
HOVERGENiHBG073535
InParanoidiQ9CZA5
OMAiRSEPIME
OrthoDBiEOG091G0AM8
PhylomeDBiQ9CZA5
TreeFamiTF335054

Miscellaneous databases

ChiTaRSiZcchc12 mouse
PROiPR:Q9CZA5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036699 Expressed in 194 organ(s), highest expression level in medial preoptic region
CleanExiMM_ZCCHC12
GenevisibleiQ9CZA5 MM

Family and domain databases

InterProiView protein in InterPro
IPR026523 PNMA
IPR001878 Znf_CCHC
PANTHERiPTHR23095 PTHR23095, 1 hit
PfamiView protein in Pfam
PF14893 PNMA, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZCH12_MOUSE
AccessioniPrimary (citable) accession number: Q9CZA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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