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Protein

Mediator of RNA polymerase II transcription subunit 18

Gene

Med18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 18
Alternative name(s):
Mediator complex subunit 18
Gene namesi
Name:Med18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1914469 Med18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003047431 – 208Mediator of RNA polymerase II transcription subunit 18Add BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei66PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9CZ82
PaxDbiQ9CZ82
PeptideAtlasiQ9CZ82
PRIDEiQ9CZ82

PTM databases

iPTMnetiQ9CZ82
PhosphoSitePlusiQ9CZ82

Expressioni

Gene expression databases

BgeeiENSMUSG00000066042 Expressed in 227 organ(s), highest expression level in CA1 field of hippocampus
ExpressionAtlasiQ9CZ82 baseline and differential
GenevisibleiQ9CZ82 MM

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).By similarity

Protein-protein interaction databases

BioGridi212025, 1 interactor
ComplexPortaliCPX-3264 Core mediator complex
IntActiQ9CZ82, 3 interactors
MINTiQ9CZ82
STRINGi10090.ENSMUSP00000099627

Structurei

3D structure databases

ProteinModelPortaliQ9CZ82
SMRiQ9CZ82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 18 family.Curated

Phylogenomic databases

eggNOGiKOG3264 Eukaryota
ENOG4110KT9 LUCA
GeneTreeiENSGT00390000003312
HOGENOMiHOG000037435
HOVERGENiHBG105560
InParanoidiQ9CZ82
KOiK15135
OMAiDHEMCFS
OrthoDBiEOG091G0K0D
PhylomeDBiQ9CZ82
TreeFamiTF313246

Family and domain databases

InterProiView protein in InterPro
IPR019095 Mediator_Med18
PANTHERiPTHR13321 PTHR13321, 1 hit
PfamiView protein in Pfam
PF09637 Med18, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CZ82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAPPVTMMP VTGGTINMME YLLQGSVLDH SLESLIHRLR GLCDNMEPET
60 70 80 90 100
FLDHEMVFLL KGQQASPFVL RARRSMDRAG APWHLRYLGQ PEMGDKNRHA
110 120 130 140 150
LVRNCVDIAT SENLTDFLME MGFRMDHEFV AKGHLFRKGI MKVVVYKIFR
160 170 180 190 200
ILVPGNTDST EALSLSYLVE LSVVAPAGQD MVSDDMRNFA EQLKPLVHLE

KIDPKRLM
Length:208
Mass (Da):23,645
Last modified:June 1, 2001 - v1
Checksum:iBA3E4AC7C6930BC3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8Y5Q6A8Y5Q6_MOUSE
Mediator of RNA polymerase II trans...
Med18 MED18
122Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012886 mRNA Translation: BAB28536.1
AK159696 mRNA Translation: BAE35296.1
AL805897 Genomic DNA No translation available.
BC068306 mRNA Translation: AAH68306.1
CCDSiCCDS18725.1
RefSeqiNP_080315.1, NM_026039.3
UniGeneiMm.45929

Genome annotation databases

EnsembliENSMUST00000102567; ENSMUSP00000099627; ENSMUSG00000066042
GeneIDi67219
KEGGimmu:67219
UCSCiuc008vbi.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012886 mRNA Translation: BAB28536.1
AK159696 mRNA Translation: BAE35296.1
AL805897 Genomic DNA No translation available.
BC068306 mRNA Translation: AAH68306.1
CCDSiCCDS18725.1
RefSeqiNP_080315.1, NM_026039.3
UniGeneiMm.45929

3D structure databases

ProteinModelPortaliQ9CZ82
SMRiQ9CZ82
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212025, 1 interactor
ComplexPortaliCPX-3264 Core mediator complex
IntActiQ9CZ82, 3 interactors
MINTiQ9CZ82
STRINGi10090.ENSMUSP00000099627

PTM databases

iPTMnetiQ9CZ82
PhosphoSitePlusiQ9CZ82

Proteomic databases

MaxQBiQ9CZ82
PaxDbiQ9CZ82
PeptideAtlasiQ9CZ82
PRIDEiQ9CZ82

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102567; ENSMUSP00000099627; ENSMUSG00000066042
GeneIDi67219
KEGGimmu:67219
UCSCiuc008vbi.2 mouse

Organism-specific databases

CTDi54797
MGIiMGI:1914469 Med18

Phylogenomic databases

eggNOGiKOG3264 Eukaryota
ENOG4110KT9 LUCA
GeneTreeiENSGT00390000003312
HOGENOMiHOG000037435
HOVERGENiHBG105560
InParanoidiQ9CZ82
KOiK15135
OMAiDHEMCFS
OrthoDBiEOG091G0K0D
PhylomeDBiQ9CZ82
TreeFamiTF313246

Miscellaneous databases

PROiPR:Q9CZ82
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066042 Expressed in 227 organ(s), highest expression level in CA1 field of hippocampus
ExpressionAtlasiQ9CZ82 baseline and differential
GenevisibleiQ9CZ82 MM

Family and domain databases

InterProiView protein in InterPro
IPR019095 Mediator_Med18
PANTHERiPTHR13321 PTHR13321, 1 hit
PfamiView protein in Pfam
PF09637 Med18, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMED18_MOUSE
AccessioniPrimary (citable) accession number: Q9CZ82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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