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Protein

Centrosomal protein of 97 kDa

Gene

Cep97

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-MMU-5620912 Anchoring of the basal body to the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 97 kDa
Short name:
Cep97
Alternative name(s):
Leucine-rich repeat and IQ domain-containing protein 2
Gene namesi
Name:Cep97
Synonyms:Lrriq2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1921451 Cep97

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002637061 – 856Centrosomal protein of 97 kDaAdd BLAST856

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei308PhosphoserineBy similarity1
Modified residuei410PhosphoserineBy similarity1
Modified residuei497PhosphoserineBy similarity1
Modified residuei521PhosphoserineCombined sources1
Modified residuei534PhosphothreonineBy similarity1
Modified residuei755PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CZ62
PaxDbiQ9CZ62
PeptideAtlasiQ9CZ62
PRIDEiQ9CZ62

PTM databases

iPTMnetiQ9CZ62
PhosphoSitePlusiQ9CZ62

Expressioni

Gene expression databases

BgeeiENSMUSG00000022604 Expressed in 229 organ(s), highest expression level in rostral migratory stream
CleanExiMM_CEP97
ExpressionAtlasiQ9CZ62 baseline and differential
GenevisibleiQ9CZ62 MM

Interactioni

Subunit structurei

Interacts with CALM1, CEP76, CCP110, KIF24, TALPID3. Via its interaction with CCP110, may indirectly interact with HERC2 and NEURL4.By similarity

Protein-protein interaction databases

BioGridi216572, 1 interactor
IntActiQ9CZ62, 2 interactors
STRINGi10090.ENSMUSP00000023270

Structurei

3D structure databases

ProteinModelPortaliQ9CZ62
SMRiQ9CZ62
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati37 – 58LRR 1Add BLAST22
Repeati59 – 80LRR 2Add BLAST22
Repeati81 – 102LRR 3Add BLAST22
Repeati103 – 124LRR 4Add BLAST22
Repeati125 – 146LRR 5Add BLAST22
Repeati147 – 168LRR 6Add BLAST22
Repeati171 – 192LRR 7Add BLAST22
Repeati196 – 205LRR 810
Domaini211 – 249LRRCTAdd BLAST39
Domaini550 – 579IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni300 – 742CCP110-bindingBy similarityAdd BLAST443

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0531 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00910000144283
HOGENOMiHOG000111550
HOVERGENiHBG061575
InParanoidiQ9CZ62
KOiK16717
OMAiEAPQEKS
OrthoDBiEOG091G02EC
PhylomeDBiQ9CZ62
TreeFamiTF320816

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51450 LRR, 7 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9CZ62-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVARVDGAL APGEGSVVNW SGQGLQKLGA NLPCEADVHT LILDKNQIIK
60 70 80 90 100
LENLEKCKQL IQLSVANNRL VRMMGVAKLT QLRVLNLPHN SIGCVEGLKD
110 120 130 140 150
LVHLEWLNLA GNNLKTMEQV NSCTALQHLD LSDNNIPQIG DVSKLISLKT
160 170 180 190 200
LLLHGNIITS LRMAPAYLPR NLSILSLAEN EIRDLNEISF LASLSELEQL
210 220 230 240 250
SIMNNPCVMA TPSIPGFDYR PFIVSWCLNL RVLDGYVISQ KESLKAEWLY
260 270 280 290 300
SQGKGRSYRP GQHIQLVQYL ATVCPLTSAL GLQTAEDAKL EKILSKQRFH
310 320 330 340 350
QRQLMSQSQD EELSPLAAVE TRVHRTPECS SPGQDFQESE PVLQINSWVG
360 370 380 390 400
ISSNDDQLYA VKNNFPAAAH AARYSRNDLH LEDIQTDEDK LNCSLLSSES
410 420 430 440 450
TFMPVASGLS PVSPTVELRL QGINLGLEDD DGADEFTKGL ENQDEDKDKE
460 470 480 490 500
KSLWDMSESC VEMLKRKIST EVSEAAGLLP CPKSVIISAA LKEDTHSLTS
510 520 530 540 550
LPESAGHSAS RTEANSEEAM SPATSEKFPC RILTQRPAAL GQDKVTLQKL
560 570 580 590 600
NAAATKLQAC WRGFYTRNYN QQAKGVRYEI RLRRMQEHIV CLTDEVRRLR
610 620 630 640 650
KERDEERVKT FVQEEAVRFL WNEVRSVQAW QQTVEQRLAS WPPDVPPISS
660 670 680 690 700
TLASPKPPLF PHHQDPSSDQ SSDWLVAEDE AAQGRSAPDF PDSGFHSSLT
710 720 730 740 750
EQVPCLQDSL DFEKSSVESS ENSVLGNSAD TVKCVKDRDS EATAEEHSDC
760 770 780 790 800
SRESSASEQD NTLLQQYLTS VQQLDDAAEA ADSDDVAGDG KRHLACSPER
810 820 830 840 850
FDASSDSETH RVASTSQDEI SQTPENCQLN EEAQGQPPEC DPAFQGLHVG

VTVQPV
Length:856
Mass (Da):94,641
Last modified:June 1, 2001 - v1
Checksum:i619F0B577D0C15A9
GO
Isoform 2 (identifier: Q9CZ62-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.

Show »
Length:784
Mass (Da):86,896
Checksum:i9FC1E774A81C81C4
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BH46Q8BH46_MOUSE
Centrosomal protein of 97 kDa
Cep97 Lrriq2, mCG_130901
158Annotation score:
Q6P077Q6P077_MOUSE
Centrosomal protein of 97 kDa
Cep97 Lrriq2
157Annotation score:
Q8BJR7Q8BJR7_MOUSE
Centrosomal protein of 97 kDa
Cep97 Lrriq2, mCG_130901
151Annotation score:

Sequence cautioni

The sequence BAC32752 differs from that shown. Reason: Frameshift at position 658.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0218831 – 72Missing in isoform 2. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012971 mRNA Translation: BAB28575.1
AK046486 mRNA Translation: BAC32752.1 Frameshift.
AK154885 mRNA Translation: BAE32902.1
BC067049 mRNA Translation: AAH67049.1
CCDSiCCDS28217.1 [Q9CZ62-1]
RefSeqiNP_001152836.1, NM_001159364.1
NP_001152837.1, NM_001159365.1
NP_001152838.1, NM_001159366.1
NP_083091.1, NM_028815.4 [Q9CZ62-1]
UniGeneiMm.178427

Genome annotation databases

EnsembliENSMUST00000023270; ENSMUSP00000023270; ENSMUSG00000022604 [Q9CZ62-1]
ENSMUST00000117468; ENSMUSP00000112687; ENSMUSG00000022604 [Q9CZ62-2]
ENSMUST00000118500; ENSMUSP00000112663; ENSMUSG00000022604 [Q9CZ62-2]
GeneIDi74201
KEGGimmu:74201
UCSCiuc007zlr.2 mouse [Q9CZ62-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012971 mRNA Translation: BAB28575.1
AK046486 mRNA Translation: BAC32752.1 Frameshift.
AK154885 mRNA Translation: BAE32902.1
BC067049 mRNA Translation: AAH67049.1
CCDSiCCDS28217.1 [Q9CZ62-1]
RefSeqiNP_001152836.1, NM_001159364.1
NP_001152837.1, NM_001159365.1
NP_001152838.1, NM_001159366.1
NP_083091.1, NM_028815.4 [Q9CZ62-1]
UniGeneiMm.178427

3D structure databases

ProteinModelPortaliQ9CZ62
SMRiQ9CZ62
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216572, 1 interactor
IntActiQ9CZ62, 2 interactors
STRINGi10090.ENSMUSP00000023270

PTM databases

iPTMnetiQ9CZ62
PhosphoSitePlusiQ9CZ62

Proteomic databases

EPDiQ9CZ62
PaxDbiQ9CZ62
PeptideAtlasiQ9CZ62
PRIDEiQ9CZ62

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023270; ENSMUSP00000023270; ENSMUSG00000022604 [Q9CZ62-1]
ENSMUST00000117468; ENSMUSP00000112687; ENSMUSG00000022604 [Q9CZ62-2]
ENSMUST00000118500; ENSMUSP00000112663; ENSMUSG00000022604 [Q9CZ62-2]
GeneIDi74201
KEGGimmu:74201
UCSCiuc007zlr.2 mouse [Q9CZ62-1]

Organism-specific databases

CTDi79598
MGIiMGI:1921451 Cep97

Phylogenomic databases

eggNOGiKOG0531 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00910000144283
HOGENOMiHOG000111550
HOVERGENiHBG061575
InParanoidiQ9CZ62
KOiK16717
OMAiEAPQEKS
OrthoDBiEOG091G02EC
PhylomeDBiQ9CZ62
TreeFamiTF320816

Enzyme and pathway databases

ReactomeiR-MMU-5620912 Anchoring of the basal body to the plasma membrane

Miscellaneous databases

ChiTaRSiCep97 mouse
PROiPR:Q9CZ62
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022604 Expressed in 229 organ(s), highest expression level in rostral migratory stream
CleanExiMM_CEP97
ExpressionAtlasiQ9CZ62 baseline and differential
GenevisibleiQ9CZ62 MM

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51450 LRR, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCEP97_MOUSE
AccessioniPrimary (citable) accession number: Q9CZ62
Secondary accession number(s): Q8BL35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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