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Protein

Anthrax toxin receptor 1

Gene

Antxr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi50Divalent metal cationBy similarity1
Metal bindingi52Divalent metal cationBy similarity1
Metal bindingi116Divalent metal cationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
LigandMetal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Anthrax toxin receptor 1
Alternative name(s):
Tumor endothelial marker 8
Gene namesi
Name:Antxr1
Synonyms:Atr, Tem8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1916788 Antxr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 319ExtracellularSequence analysisAdd BLAST289
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Topological domaini341 – 562CytoplasmicSequence analysisAdd BLAST222

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000000269331 – 562Anthrax toxin receptor 1Add BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 218By similarity
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi182N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei360PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9CZ52
PeptideAtlasiQ9CZ52
PRIDEiQ9CZ52

PTM databases

iPTMnetiQ9CZ52
PhosphoSitePlusiQ9CZ52
SwissPalmiQ9CZ52

Expressioni

Gene expression databases

BgeeiENSMUSG00000033420 Expressed in 254 organ(s), highest expression level in embryo
CleanExiMM_ANTXR1
MM_ATR
ExpressionAtlasiQ9CZ52 baseline and differential
GenevisibleiQ9CZ52 MM

Interactioni

Subunit structurei

Interacts with gelatin and type 1 collagen. Interacts with the actin cytoskeleton. Binds to the protective antigen (PA) of Bacillus anthracis. Binding does not occur in the presence of calcium (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213512, 1 interactor
STRINGi10090.ENSMUSP00000045634

Structurei

3D structure databases

ProteinModelPortaliQ9CZ52
SMRiQ9CZ52
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 213VWFAPROSITE-ProRule annotationAdd BLAST172

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni152 – 158Interaction with PABy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi358 – 366Asp/Glu-rich (highly acidic)9
Compositional biasi501 – 562Pro-richAdd BLAST62

Domaini

Binding to PA occurs through the VWA domain.By similarity

Sequence similaritiesi

Belongs to the ATR family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK1W Eukaryota
ENOG410YC57 LUCA
GeneTreeiENSGT00430000031214
HOGENOMiHOG000264249
HOVERGENiHBG050514
InParanoidiQ9CZ52
KOiK20909
OMAiFTVEDTY
OrthoDBiEOG091G08TW
PhylomeDBiQ9CZ52
TreeFamiTF328943

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR017360 Anthrax_toxin_rcpt
IPR008399 Anthrax_toxin_rcpt_C
IPR008400 Anthrax_toxin_rcpt_extracel
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR16059 PTHR16059, 1 hit
PfamiView protein in Pfam
PF05586 Ant_C, 1 hit
PF05587 Anth_Ig, 1 hit
PF00092 VWA, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD377005 Anthrax_toxin_rcpt_C, 1 hit
SMARTiView protein in SMART
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50234 VWFA, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9CZ52-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDRAGRLGAG LRGLCVAALV LVCAGHGGRR EDGGPACYGG FDLYFILDKS
60 70 80 90 100
GSVLHHWNEI YYFVEQLAHR FISPQLRMSF IVFSTRGTTL MKLTEDREQI
110 120 130 140 150
RQGLEELQKV LPGGDTYMHE GFERASEQIY YENSQGYRTA SVIIALTDGE
160 170 180 190 200
LHEDLFFYSE REANRSRDLG AIVYCVGVKD FNETQLARIA DSKDHVFPVN
210 220 230 240 250
DGFQALQGII HSILKKSCIE ILAAEPSTIC AGESFQVVVR GNGFRHARNV
260 270 280 290 300
DRVLCSFKIN DSVTLNEKPF AVEDTYLLCP APILKEVGMK AALQVSMNDG
310 320 330 340 350
LSFISSSVII TTTHCSDGSI LAIALLVLFL LLALALLWWF WPLCCTVIIK
360 370 380 390 400
EVPPPPVEES EEEDDDGLPK KKWPTVDASY YGGRGVGGIK RMEVRWGEKG
410 420 430 440 450
STEEGAKLEK AKNARVKMPE QEYEFPEPRN LNNNMRRPSS PRKWYSPIKG
460 470 480 490 500
KLDALWVLLR KGYDRVSVMR PQPGDTGRCI NFTRVKNSQP AKYPLNNTYH
510 520 530 540 550
PSSPPPAPIY TPPPPAPHCP PPAPSAPTPP IPSPPSTLPP PPQAPPPNRA
560
PPPSRPPPRP SV
Length:562
Mass (Da):62,308
Last modified:November 2, 2001 - v2
Checksum:i6AC92049B4BB4F7C
GO
Isoform 2 (identifier: Q9CZ52-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     477-562: GRCINFTRVK...PSRPPPRPSV → RFRGWRLTIC...FSSFLERAFQ

Note: No experimental confirmation available.
Show »
Length:521
Mass (Da):58,615
Checksum:i95FC613140B6B790
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SV16A0A0N4SV16_MOUSE
Anthrax toxin receptor 1
Antxr1
500Annotation score:
A0A0N4SUW7A0A0N4SUW7_MOUSE
Anthrax toxin receptor 1
Antxr1
138Annotation score:

Sequence cautioni

The sequence BAB28591 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000450477 – 562GRCIN…PRPSV → RFRGWRLTICLGSKHVHPGR HDKGPETPLLKQAWMFSSFL ERAFQ in isoform 2. 1 PublicationAdd BLAST86

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378762 mRNA Translation: AAL11999.1
BC094544 mRNA Translation: AAH94544.1
AK013005 mRNA Translation: BAB28591.1 Different initiation.
CCDSiCCDS20318.1 [Q9CZ52-1]
RefSeqiNP_473382.1, NM_054041.2 [Q9CZ52-1]
UniGeneiMm.232525

Genome annotation databases

EnsembliENSMUST00000042025; ENSMUSP00000045634; ENSMUSG00000033420 [Q9CZ52-1]
ENSMUST00000204805; ENSMUSP00000145105; ENSMUSG00000033420 [Q9CZ52-2]
GeneIDi69538
KEGGimmu:69538
UCSCiuc009cte.1 mouse [Q9CZ52-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378762 mRNA Translation: AAL11999.1
BC094544 mRNA Translation: AAH94544.1
AK013005 mRNA Translation: BAB28591.1 Different initiation.
CCDSiCCDS20318.1 [Q9CZ52-1]
RefSeqiNP_473382.1, NM_054041.2 [Q9CZ52-1]
UniGeneiMm.232525

3D structure databases

ProteinModelPortaliQ9CZ52
SMRiQ9CZ52
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213512, 1 interactor
STRINGi10090.ENSMUSP00000045634

PTM databases

iPTMnetiQ9CZ52
PhosphoSitePlusiQ9CZ52
SwissPalmiQ9CZ52

Proteomic databases

PaxDbiQ9CZ52
PeptideAtlasiQ9CZ52
PRIDEiQ9CZ52

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042025; ENSMUSP00000045634; ENSMUSG00000033420 [Q9CZ52-1]
ENSMUST00000204805; ENSMUSP00000145105; ENSMUSG00000033420 [Q9CZ52-2]
GeneIDi69538
KEGGimmu:69538
UCSCiuc009cte.1 mouse [Q9CZ52-1]

Organism-specific databases

CTDi84168
MGIiMGI:1916788 Antxr1

Phylogenomic databases

eggNOGiENOG410IK1W Eukaryota
ENOG410YC57 LUCA
GeneTreeiENSGT00430000031214
HOGENOMiHOG000264249
HOVERGENiHBG050514
InParanoidiQ9CZ52
KOiK20909
OMAiFTVEDTY
OrthoDBiEOG091G08TW
PhylomeDBiQ9CZ52
TreeFamiTF328943

Miscellaneous databases

ChiTaRSiAntxr1 mouse
PROiPR:Q9CZ52
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033420 Expressed in 254 organ(s), highest expression level in embryo
CleanExiMM_ANTXR1
MM_ATR
ExpressionAtlasiQ9CZ52 baseline and differential
GenevisibleiQ9CZ52 MM

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR017360 Anthrax_toxin_rcpt
IPR008399 Anthrax_toxin_rcpt_C
IPR008400 Anthrax_toxin_rcpt_extracel
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR16059 PTHR16059, 1 hit
PfamiView protein in Pfam
PF05586 Ant_C, 1 hit
PF05587 Anth_Ig, 1 hit
PF00092 VWA, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD377005 Anthrax_toxin_rcpt_C, 1 hit
SMARTiView protein in SMART
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50234 VWFA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiANTR1_MOUSE
AccessioniPrimary (citable) accession number: Q9CZ52
Secondary accession number(s): Q505H2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 2, 2001
Last modified: October 10, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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