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Protein

Vacuolar-sorting protein SNF8

Gene

Snf8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transcription, Transcription regulation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar-sorting protein SNF8
Alternative name(s):
ESCRT-II complex subunit VPS22
Gene namesi
Name:Snf8
Synonyms:D11Moh34
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1343161 Snf8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002152101 – 258Vacuolar-sorting protein SNF8Add BLAST258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ9CZ28
MaxQBiQ9CZ28
PaxDbiQ9CZ28
PeptideAtlasiQ9CZ28
PRIDEiQ9CZ28

PTM databases

iPTMnetiQ9CZ28
PhosphoSitePlusiQ9CZ28

Expressioni

Gene expression databases

BgeeiENSMUSG00000006058 Expressed in 280 organ(s), highest expression level in cerebral cortex
ExpressionAtlasiQ9CZ28 baseline and differential
GenevisibleiQ9CZ28 MM

Interactioni

Subunit structurei

Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of SNF8, VPS25 and VPS36. SNF8 is essential for the stability of the ESCRT-II complex. ESCRT-II interacts with ELL. Interacts with TSG101 (via the C-terminal domain). Interacts with RILPL1 (via the N-terminal domain); which recruits ESCRT-II to the endosome membranes. Interacts with 14-3-3 proteins (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi205435, 5 interactors
IntActiQ9CZ28, 5 interactors
MINTiQ9CZ28
STRINGi10090.ENSMUSP00000006217

Structurei

3D structure databases

ProteinModelPortaliQ9CZ28
SMRiQ9CZ28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili27 – 53Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the SNF8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3341 Eukaryota
ENOG410XPVM LUCA
GeneTreeiENSGT00390000007843
HOGENOMiHOG000170930
HOVERGENiHBG079872
InParanoidiQ9CZ28
KOiK12188
OMAiAQFARMC
OrthoDBiEOG091G0GWO
PhylomeDBiQ9CZ28
TreeFamiTF105950

Family and domain databases

Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR016689 ESCRT-2_cplx_Snf8
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR12806 PTHR12806, 1 hit
PIRSFiPIRSF017215 ESCRT2_Vps22, 1 hit
SUPFAMiSSF46785 SSF46785, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CZ28-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHRRGVGAGA IAKKKLAEAK YKERGTVLAE DQLAQMSKQL DMFKTNLEEF
60 70 80 90 100
ASKHKQEIRK NPEFRVQFQD MCATIGVDPL ASGKGFWSEM LGVGDFYYEL
110 120 130 140 150
GVQIIEVCLA LKHRNGGLIT LEELHQQVLK GRGKFAQDVS QDDLIRAIKK
160 170 180 190 200
LKALGTGFGI IPVGGTYLIQ SVPAELNMDH TVVLQLAEKN GYVTVSEIKT
210 220 230 240 250
SLKWETERAR QVLEHLLKEG LAWLDLQAPG EAHYWLPALF TDLYSQEISA

EEAKEAFP
Length:258
Mass (Da):28,886
Last modified:June 1, 2001 - v1
Checksum:iFD64947ED7815D5E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A6M1A2A6M1_MOUSE
Vacuolar-sorting protein SNF8
Snf8
233Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013058 mRNA Translation: BAB28626.1
AL603682 Genomic DNA No translation available.
BC003938 mRNA Translation: AAH03938.1
CCDSiCCDS25288.1
RefSeqiNP_291046.1, NM_033568.2
UniGeneiMm.372235

Genome annotation databases

EnsembliENSMUST00000006217; ENSMUSP00000006217; ENSMUSG00000006058
GeneIDi27681
KEGGimmu:27681
UCSCiuc007lbb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013058 mRNA Translation: BAB28626.1
AL603682 Genomic DNA No translation available.
BC003938 mRNA Translation: AAH03938.1
CCDSiCCDS25288.1
RefSeqiNP_291046.1, NM_033568.2
UniGeneiMm.372235

3D structure databases

ProteinModelPortaliQ9CZ28
SMRiQ9CZ28
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205435, 5 interactors
IntActiQ9CZ28, 5 interactors
MINTiQ9CZ28
STRINGi10090.ENSMUSP00000006217

PTM databases

iPTMnetiQ9CZ28
PhosphoSitePlusiQ9CZ28

Proteomic databases

EPDiQ9CZ28
MaxQBiQ9CZ28
PaxDbiQ9CZ28
PeptideAtlasiQ9CZ28
PRIDEiQ9CZ28

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006217; ENSMUSP00000006217; ENSMUSG00000006058
GeneIDi27681
KEGGimmu:27681
UCSCiuc007lbb.1 mouse

Organism-specific databases

CTDi11267
MGIiMGI:1343161 Snf8

Phylogenomic databases

eggNOGiKOG3341 Eukaryota
ENOG410XPVM LUCA
GeneTreeiENSGT00390000007843
HOGENOMiHOG000170930
HOVERGENiHBG079872
InParanoidiQ9CZ28
KOiK12188
OMAiAQFARMC
OrthoDBiEOG091G0GWO
PhylomeDBiQ9CZ28
TreeFamiTF105950

Enzyme and pathway databases

ReactomeiR-MMU-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Miscellaneous databases

PROiPR:Q9CZ28
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006058 Expressed in 280 organ(s), highest expression level in cerebral cortex
ExpressionAtlasiQ9CZ28 baseline and differential
GenevisibleiQ9CZ28 MM

Family and domain databases

Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR016689 ESCRT-2_cplx_Snf8
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR12806 PTHR12806, 1 hit
PIRSFiPIRSF017215 ESCRT2_Vps22, 1 hit
SUPFAMiSSF46785 SSF46785, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSNF8_MOUSE
AccessioniPrimary (citable) accession number: Q9CZ28
Secondary accession number(s): A2A6M2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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