UniProtKB - Q9CZ15 (PSF1_MOUSE)
Protein
DNA replication complex GINS protein PSF1
Gene
Gins1
Organism
Mus musculus (Mouse)
Status
Functioni
Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.By similarity
GO - Biological processi
- DNA replication Source: MGI
- DNA strand elongation involved in mitotic DNA replication Source: GO_Central
- inner cell mass cell proliferation Source: MGI
Keywordsi
Biological process | DNA replication |
Enzyme and pathway databases
Reactomei | R-MMU-176974, Unwinding of DNA |
Names & Taxonomyi
Protein namesi | Recommended name: DNA replication complex GINS protein PSF1Alternative name(s): GINS complex subunit 1 |
Gene namesi | Name:Gins1 Synonyms:Psf1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1916520, Gins1 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Other locations
- Chromosome By similarity
Note: Associates with chromatin.By similarity
Nucleus
- CMG complex Source: UniProtKB
- GINS complex Source: GO_Central
- nucleus Source: MGI
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
Chromosome, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219036 | 1 – 196 | DNA replication complex GINS protein PSF1Add BLAST | 196 |
Proteomic databases
EPDi | Q9CZ15 |
MaxQBi | Q9CZ15 |
PaxDbi | Q9CZ15 |
PeptideAtlasi | Q9CZ15 |
PRIDEi | Q9CZ15 |
PTM databases
iPTMneti | Q9CZ15 |
PhosphoSitePlusi | Q9CZ15 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000027454, Expressed in embryo and 229 other tissues |
Genevisiblei | Q9CZ15, MM |
Interactioni
Subunit structurei
Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4.
Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro (By similarity).
Component of the CMG helicase complex, composed of the MCM2-7 complex, the GINS complex and CDC45 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 213326, 1 interactor |
ComplexPortali | CPX-4502, GINS complex |
STRINGi | 10090.ENSMUSP00000028948 |
Miscellaneous databases
RNActi | Q9CZ15, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the GINS1/PSF1 family.Curated
Phylogenomic databases
eggNOGi | KOG3303, Eukaryota |
GeneTreei | ENSGT00390000013968 |
HOGENOMi | CLU_079191_1_1_1 |
InParanoidi | Q9CZ15 |
OMAi | HLCMRRN |
OrthoDBi | 1249159at2759 |
PhylomeDBi | Q9CZ15 |
TreeFami | TF312848 |
Family and domain databases
CDDi | cd11710, GINS_A_psf1, 1 hit |
InterProi | View protein in InterPro IPR036224, GINS_bundle-like_dom_sf IPR005339, GINS_Psf1 |
PANTHERi | PTHR12914, PTHR12914, 1 hit |
SUPFAMi | SSF158573, SSF158573, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9CZ15-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFCEKAMELV RELHRAPEGQ LPAFNEDGLR QVLEEMKALY EQNQSDVNEA
60 70 80 90 100
KSAGRGDLIP TVKFRHCALL RNRRCTIAYL YDRLLRIRAL RWEYGSVLPN
110 120 130 140 150
SLRFHMSAEE TEWFNHYKKS LATYMRSLGG DEGLDITQDV KPPKSLYIEV
160 170 180 190
RCLKDYGEFE VDDGTSVLLK KNSQHFLPRW KCEQLIRQGV LEHVLS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK013116 mRNA Translation: BAB28658.1 |
CCDSi | CCDS50743.1 |
RefSeqi | NP_081290.1, NM_027014.1 |
Genome annotation databases
Ensembli | ENSMUST00000028948; ENSMUSP00000028948; ENSMUSG00000027454 |
GeneIDi | 69270 |
KEGGi | mmu:69270 |
UCSCi | uc008mus.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK013116 mRNA Translation: BAB28658.1 |
CCDSi | CCDS50743.1 |
RefSeqi | NP_081290.1, NM_027014.1 |
3D structure databases
SMRi | Q9CZ15 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 213326, 1 interactor |
ComplexPortali | CPX-4502, GINS complex |
STRINGi | 10090.ENSMUSP00000028948 |
PTM databases
iPTMneti | Q9CZ15 |
PhosphoSitePlusi | Q9CZ15 |
Proteomic databases
EPDi | Q9CZ15 |
MaxQBi | Q9CZ15 |
PaxDbi | Q9CZ15 |
PeptideAtlasi | Q9CZ15 |
PRIDEi | Q9CZ15 |
Protocols and materials databases
Antibodypediai | 10061, 168 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000028948; ENSMUSP00000028948; ENSMUSG00000027454 |
GeneIDi | 69270 |
KEGGi | mmu:69270 |
UCSCi | uc008mus.2, mouse |
Organism-specific databases
CTDi | 9837 |
MGIi | MGI:1916520, Gins1 |
Phylogenomic databases
eggNOGi | KOG3303, Eukaryota |
GeneTreei | ENSGT00390000013968 |
HOGENOMi | CLU_079191_1_1_1 |
InParanoidi | Q9CZ15 |
OMAi | HLCMRRN |
OrthoDBi | 1249159at2759 |
PhylomeDBi | Q9CZ15 |
TreeFami | TF312848 |
Enzyme and pathway databases
Reactomei | R-MMU-176974, Unwinding of DNA |
Miscellaneous databases
BioGRID-ORCSi | 69270, 9 hits in 18 CRISPR screens |
ChiTaRSi | Tap1, mouse |
PROi | PR:Q9CZ15 |
RNActi | Q9CZ15, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027454, Expressed in embryo and 229 other tissues |
Genevisiblei | Q9CZ15, MM |
Family and domain databases
CDDi | cd11710, GINS_A_psf1, 1 hit |
InterProi | View protein in InterPro IPR036224, GINS_bundle-like_dom_sf IPR005339, GINS_Psf1 |
PANTHERi | PTHR12914, PTHR12914, 1 hit |
SUPFAMi | SSF158573, SSF158573, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PSF1_MOUSE | |
Accessioni | Q9CZ15Primary (citable) accession number: Q9CZ15 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2005 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families