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Protein

Single-stranded DNA-binding protein 2

Gene

Ssbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Single-stranded DNA-binding protein 2
Alternative name(s):
Sequence-specific single-stranded-DNA-binding protein 2
Gene namesi
Name:Ssbp2
Synonyms:Ssdp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1914220 Ssbp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001238271 – 361Single-stranded DNA-binding protein 2Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6N6-acetyllysineCombined sources1
Modified residuei321PhosphoserineCombined sources1
Modified residuei333PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9CYZ8
PRIDEiQ9CYZ8

PTM databases

iPTMnetiQ9CYZ8
PhosphoSitePlusiQ9CYZ8

Expressioni

Gene expression databases

BgeeiENSMUSG00000003992 Expressed in 296 organ(s), highest expression level in striatum
CleanExiMM_SSBP2
ExpressionAtlasiQ9CYZ8 baseline and differential
GenevisibleiQ9CYZ8 MM

Interactioni

Protein-protein interaction databases

BioGridi211844, 18 interactors
IntActiQ9CYZ8, 3 interactors
MINTiQ9CYZ8
STRINGi10090.ENSMUSP00000004094

Structurei

3D structure databases

ProteinModelPortaliQ9CYZ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 50LisHPROSITE-ProRule annotationAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi100 – 293Pro-richAdd BLAST194
Compositional biasi147 – 312Gly-richAdd BLAST166

Phylogenomic databases

eggNOGiKOG4594 Eukaryota
ENOG410XPQX LUCA
GeneTreeiENSGT00390000009187
HOGENOMiHOG000037785
HOVERGENiHBG068487
InParanoidiQ9CYZ8
OMAiMGPNTMG
OrthoDBiEOG091G111C
PhylomeDBiQ9CYZ8
TreeFamiTF318961

Family and domain databases

InterProiView protein in InterPro
IPR006594 LisH
IPR008116 SSDP_DNA-bd
PRINTSiPR01743 SSDNABINDING
SMARTiView protein in SMART
SM00667 LisH, 1 hit
PROSITEiView protein in PROSITE
PS50896 LISH, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9CYZ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYGKGKSNSS AVPSDSQARE KLALYVYEYL LHVGAQKSAQ TFLSEIRWEK
60 70 80 90 100
NITLGEPPGF LHSWWCVFWD LYCAAPERRE TCEHSSEAKA FHDYSAAAAP
110 120 130 140 150
SPVLGNMPPG DGMPVGPVPP GFFQPFMSPR YPGGPRPPLR IPNQALGGVP
160 170 180 190 200
GSQPLLPSGM DPTRQQGHPN MGGPMQRMTP PRGMVPLGPQ NYGGAMRPPL
210 220 230 240 250
NALGGPGMPG MNMGPGGGRP WPNPTNANSI PYSSASPGNY VGPPGGGGPP
260 270 280 290 300
GTPIMPSPAD STNSGDNMYT LMNAVPPGPN RPNFPMGPGS DGPMGGLGGM
310 320 330 340 350
ESHHMNGSLG SGDMDSISKN SPNNMSLSNQ PGTPRDDGEM GGNFLNPFQS
360
ESYSPSMTMS V
Length:361
Mass (Da):37,846
Last modified:June 1, 2001 - v1
Checksum:iEC6F98DCEBFF662E
GO
Isoform 2 (identifier: Q9CYZ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-124: Missing.

Note: No experimental confirmation available.
Show »
Length:331
Mass (Da):35,000
Checksum:i3496A6875143F773
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RG78D6RG78_MOUSE
Single-stranded DNA-binding protein...
Ssbp2
49Annotation score:
A0A338P6Q9A0A338P6Q9_MOUSE
Single-stranded DNA-binding protein...
Ssbp2
244Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00625995 – 124Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037837 mRNA Translation: AAK71881.1
AK013177 mRNA Translation: BAB28693.1
CT009700, AC154320 Genomic DNA Translation: CAO77907.1
BC002176 mRNA Translation: AAH02176.1
CCDSiCCDS26676.1 [Q9CYZ8-2]
CCDS26677.1 [Q9CYZ8-1]
RefSeqiNP_077148.1, NM_024186.5 [Q9CYZ8-2]
NP_077234.2, NM_024272.4 [Q9CYZ8-1]
UniGeneiMm.343095

Genome annotation databases

EnsembliENSMUST00000004094; ENSMUSP00000004094; ENSMUSG00000003992 [Q9CYZ8-1]
ENSMUST00000042122; ENSMUSP00000037115; ENSMUSG00000003992 [Q9CYZ8-2]
GeneIDi66970
KEGGimmu:66970
UCSCiuc007rjv.2 mouse [Q9CYZ8-1]
uc007rjw.2 mouse [Q9CYZ8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037837 mRNA Translation: AAK71881.1
AK013177 mRNA Translation: BAB28693.1
CT009700, AC154320 Genomic DNA Translation: CAO77907.1
BC002176 mRNA Translation: AAH02176.1
CCDSiCCDS26676.1 [Q9CYZ8-2]
CCDS26677.1 [Q9CYZ8-1]
RefSeqiNP_077148.1, NM_024186.5 [Q9CYZ8-2]
NP_077234.2, NM_024272.4 [Q9CYZ8-1]
UniGeneiMm.343095

3D structure databases

ProteinModelPortaliQ9CYZ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211844, 18 interactors
IntActiQ9CYZ8, 3 interactors
MINTiQ9CYZ8
STRINGi10090.ENSMUSP00000004094

PTM databases

iPTMnetiQ9CYZ8
PhosphoSitePlusiQ9CYZ8

Proteomic databases

PaxDbiQ9CYZ8
PRIDEiQ9CYZ8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004094; ENSMUSP00000004094; ENSMUSG00000003992 [Q9CYZ8-1]
ENSMUST00000042122; ENSMUSP00000037115; ENSMUSG00000003992 [Q9CYZ8-2]
GeneIDi66970
KEGGimmu:66970
UCSCiuc007rjv.2 mouse [Q9CYZ8-1]
uc007rjw.2 mouse [Q9CYZ8-2]

Organism-specific databases

CTDi23635
MGIiMGI:1914220 Ssbp2

Phylogenomic databases

eggNOGiKOG4594 Eukaryota
ENOG410XPQX LUCA
GeneTreeiENSGT00390000009187
HOGENOMiHOG000037785
HOVERGENiHBG068487
InParanoidiQ9CYZ8
OMAiMGPNTMG
OrthoDBiEOG091G111C
PhylomeDBiQ9CYZ8
TreeFamiTF318961

Miscellaneous databases

ChiTaRSiSsbp2 mouse
PROiPR:Q9CYZ8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003992 Expressed in 296 organ(s), highest expression level in striatum
CleanExiMM_SSBP2
ExpressionAtlasiQ9CYZ8 baseline and differential
GenevisibleiQ9CYZ8 MM

Family and domain databases

InterProiView protein in InterPro
IPR006594 LisH
IPR008116 SSDP_DNA-bd
PRINTSiPR01743 SSDNABINDING
SMARTiView protein in SMART
SM00667 LisH, 1 hit
PROSITEiView protein in PROSITE
PS50896 LISH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSSBP2_MOUSE
AccessioniPrimary (citable) accession number: Q9CYZ8
Secondary accession number(s): B1B188, Q99LX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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