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Protein

Tumor protein D54

Gene

Tpd52l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor protein D54
Alternative name(s):
Tumor protein D52-like 2
Gene namesi
Name:Tpd52l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1913564 Tpd52l2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001857451 – 220Tumor protein D54Add BLAST220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei3PhosphoserineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei19PhosphoserineBy similarity1
Modified residuei96PhosphoserineCombined sources1
Modified residuei149PhosphoserineBy similarity1
Modified residuei168PhosphoserineCombined sources1
Modified residuei175PhosphoserineBy similarity1
Modified residuei177PhosphothreonineBy similarity1
Modified residuei180PhosphoserineCombined sources1
Modified residuei187PhosphothreonineBy similarity1
Modified residuei206PhosphoserineCombined sources1
Modified residuei209PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CYZ2
MaxQBiQ9CYZ2
PaxDbiQ9CYZ2
PeptideAtlasiQ9CYZ2
PRIDEiQ9CYZ2

PTM databases

iPTMnetiQ9CYZ2
PhosphoSitePlusiQ9CYZ2

Expressioni

Gene expression databases

BgeeiENSMUSG00000000827 Expressed in 288 organ(s), highest expression level in ear
CleanExiMM_TPD52L2
ExpressionAtlasiQ9CYZ2 baseline and differential
GenevisibleiQ9CYZ2 MM

Interactioni

Subunit structurei

Forms a homodimer or heterodimer with other members of the family. Interacts with MAL2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211377, 2 interactors
IntActiQ9CYZ2, 3 interactors
MINTiQ9CYZ2
STRINGi10090.ENSMUSP00000117690

Structurei

3D structure databases

ProteinModelPortaliQ9CYZ2
SMRiQ9CYZ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili40 – 82Sequence analysisAdd BLAST43

Sequence similaritiesi

Belongs to the TPD52 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4010 Eukaryota
ENOG4111M9H LUCA
GeneTreeiENSGT00390000015988
HOGENOMiHOG000231968
HOVERGENiHBG058643
InParanoidiQ9CYZ2
PhylomeDBiQ9CYZ2
TreeFamiTF317562

Family and domain databases

InterProiView protein in InterPro
IPR007327 TPD52
PANTHERiPTHR19307 PTHR19307, 1 hit
PfamiView protein in Pfam
PF04201 TPD52, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.iShow all

Q9CYZ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSASQDINL NSPNKGVLSD FMTDVPVDPG VVHRTPVVEG LTEGEEEELR
60 70 80 90 100
AELAKVEEEI VTLRQVLAAK ERHCGELKRR LGLSTLGELK QNLSRSWHDV
110 120 130 140 150
QVSTAYVKTS EKLGEWNEKV TQSDLYKKTQ ETLSQAGQKT SAALSTMGSA
160 170 180 190 200
ISRKLGDMSS YSIRHSISMP VMRNSATFKS FEDRVGTIKS KVVGGRENGS
210 220
DNLPPSPGSG DQTLPDHAPF
Length:220
Mass (Da):24,043
Last modified:June 1, 2001 - v1
Checksum:i276776288500D9C8
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AUD5A2AUD5_MOUSE
Tumor protein D54
Tpd52l2
229Annotation score:
Q3TUJ9Q3TUJ9_MOUSE
Tumor protein D52-like 2, isoform C...
Tpd52l2 mCG_23059
186Annotation score:
Q8BKP1Q8BKP1_MOUSE
Tumor protein D52-like 2, isoform C...
Tpd52l2 mCG_23059
200Annotation score:
Q3TAI4Q3TAI4_MOUSE
Tumor protein D52-like 2, isoform C...
Tpd52l2 mCG_23059
206Annotation score:
V9GWU5V9GWU5_MOUSE
Tumor protein D54
Tpd52l2
169Annotation score:
F6VQ81F6VQ81_MOUSE
Tumor protein D54
Tpd52l2
161Annotation score:
V9GXN2V9GXN2_MOUSE
Tumor protein D54
Tpd52l2
45Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013188 mRNA Translation: BAB28701.1
AK159925 mRNA Translation: BAE35487.1
BC006886 mRNA Translation: AAH06886.1
CCDSiCCDS17214.1
RefSeqiNP_001278126.1, NM_001291197.1
NP_079758.2, NM_025482.3
UniGeneiMm.136648

Genome annotation databases

EnsembliENSMUST00000149163; ENSMUSP00000117690; ENSMUSG00000000827
GeneIDi66314
KEGGimmu:66314
UCSCiuc008oml.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013188 mRNA Translation: BAB28701.1
AK159925 mRNA Translation: BAE35487.1
BC006886 mRNA Translation: AAH06886.1
CCDSiCCDS17214.1
RefSeqiNP_001278126.1, NM_001291197.1
NP_079758.2, NM_025482.3
UniGeneiMm.136648

3D structure databases

ProteinModelPortaliQ9CYZ2
SMRiQ9CYZ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211377, 2 interactors
IntActiQ9CYZ2, 3 interactors
MINTiQ9CYZ2
STRINGi10090.ENSMUSP00000117690

PTM databases

iPTMnetiQ9CYZ2
PhosphoSitePlusiQ9CYZ2

Proteomic databases

EPDiQ9CYZ2
MaxQBiQ9CYZ2
PaxDbiQ9CYZ2
PeptideAtlasiQ9CYZ2
PRIDEiQ9CYZ2

Protocols and materials databases

DNASUi66314
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000149163; ENSMUSP00000117690; ENSMUSG00000000827
GeneIDi66314
KEGGimmu:66314
UCSCiuc008oml.2 mouse

Organism-specific databases

CTDi7165
MGIiMGI:1913564 Tpd52l2

Phylogenomic databases

eggNOGiKOG4010 Eukaryota
ENOG4111M9H LUCA
GeneTreeiENSGT00390000015988
HOGENOMiHOG000231968
HOVERGENiHBG058643
InParanoidiQ9CYZ2
PhylomeDBiQ9CYZ2
TreeFamiTF317562

Miscellaneous databases

ChiTaRSiTpd52l2 mouse
PROiPR:Q9CYZ2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000827 Expressed in 288 organ(s), highest expression level in ear
CleanExiMM_TPD52L2
ExpressionAtlasiQ9CYZ2 baseline and differential
GenevisibleiQ9CYZ2 MM

Family and domain databases

InterProiView protein in InterPro
IPR007327 TPD52
PANTHERiPTHR19307 PTHR19307, 1 hit
PfamiView protein in Pfam
PF04201 TPD52, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTPD54_MOUSE
AccessioniPrimary (citable) accession number: Q9CYZ2
Secondary accession number(s): Q3TVY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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