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Entry version 113 (16 Jan 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Haloacid dehalogenase-like hydrolase domain-containing protein 3

Gene

Hdhd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Haloacid dehalogenase-like hydrolase domain-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hdhd3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:1919998 Hdhd3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002873141 – 251Haloacid dehalogenase-like hydrolase domain-containing protein 3Add BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei15N6-acetyllysine; alternateCombined sources1
Modified residuei15N6-succinyllysine; alternateCombined sources1
Modified residuei130N6-acetyllysineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9CYW4

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9CYW4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9CYW4

PeptideAtlas

More...
PeptideAtlasi
Q9CYW4

PRoteomics IDEntifications database

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PRIDEi
Q9CYW4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9CYW4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9CYW4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000038422 Expressed in 172 organ(s), highest expression level in colon

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9CYW4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q9CYW4, 1 interactor

Molecular INTeraction database

More...
MINTi
Q9CYW4

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000036337

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9CYW4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9CYW4

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3085 Eukaryota
COG1011 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015582

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000075006

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG101862

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9CYW4

Identification of Orthologs from Complete Genome Data

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OMAi
CDYQGAR

Database of Orthologous Groups

More...
OrthoDBi
1119971at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9CYW4

TreeFam database of animal gene trees

More...
TreeFami
TF315144

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036412 HAD-like_sf
IPR006439 HAD-SF_hydro_IA
IPR011949 HAD-SF_hydro_IA_REG-2-like
IPR023214 HAD_sf

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00413 HADHALOGNASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784 SSF56784, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02252 DREG-2, 1 hit
TIGR01549 HAD-SF-IA-v1, 1 hit
TIGR01509 HAD-SF-IA-v3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9CYW4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHRLQMRLL TWDVKDTLIK LRRPVGEEYA SKARAHGVVV EDITVEQAFR
60 70 80 90 100
QAYRAQSHNF PNYGLSRGLT SRQWWKDVVL HTFRLAGVPD AQAMTPVADQ
110 120 130 140 150
LYEDFSSPFT WQVLEGAEMT LKGCRKRGLK LAVVSNFDRR LEDILTGLGL
160 170 180 190 200
REHFDFVLTS EAVGCPKPDP RIFREALQRA CVEPAVAAHV GDSYLCDYQG
210 220 230 240 250
SQAVGMHSFL VAGSEPLDSA VRDSVPKEHI LPSLSHLLPA LDLLEASSPM

S
Length:251
Mass (Da):28,027
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE547C44964F569D2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK013245 mRNA Translation: BAB28741.1
AL732594 Genomic DNA No translation available.
BC003491 mRNA Translation: AAH03491.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS18242.1

NCBI Reference Sequences

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RefSeqi
NP_077219.1, NM_024257.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.41506

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000037820; ENSMUSP00000036337; ENSMUSG00000038422

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
72748

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:72748

UCSC genome browser

More...
UCSCi
uc008tey.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013245 mRNA Translation: BAB28741.1
AL732594 Genomic DNA No translation available.
BC003491 mRNA Translation: AAH03491.1
CCDSiCCDS18242.1
RefSeqiNP_077219.1, NM_024257.1
UniGeneiMm.41506

3D structure databases

ProteinModelPortaliQ9CYW4
SMRiQ9CYW4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CYW4, 1 interactor
MINTiQ9CYW4
STRINGi10090.ENSMUSP00000036337

PTM databases

iPTMnetiQ9CYW4
PhosphoSitePlusiQ9CYW4

Proteomic databases

jPOSTiQ9CYW4
MaxQBiQ9CYW4
PaxDbiQ9CYW4
PeptideAtlasiQ9CYW4
PRIDEiQ9CYW4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037820; ENSMUSP00000036337; ENSMUSG00000038422
GeneIDi72748
KEGGimmu:72748
UCSCiuc008tey.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
81932
MGIiMGI:1919998 Hdhd3

Phylogenomic databases

eggNOGiKOG3085 Eukaryota
COG1011 LUCA
GeneTreeiENSGT00390000015582
HOGENOMiHOG000075006
HOVERGENiHBG101862
InParanoidiQ9CYW4
OMAiCDYQGAR
OrthoDBi1119971at2759
PhylomeDBiQ9CYW4
TreeFamiTF315144

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9CYW4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000038422 Expressed in 172 organ(s), highest expression level in colon
GenevisibleiQ9CYW4 MM

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR006439 HAD-SF_hydro_IA
IPR011949 HAD-SF_hydro_IA_REG-2-like
IPR023214 HAD_sf
PRINTSiPR00413 HADHALOGNASE
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR02252 DREG-2, 1 hit
TIGR01549 HAD-SF-IA-v1, 1 hit
TIGR01509 HAD-SF-IA-v3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHDHD3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9CYW4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2001
Last modified: January 16, 2019
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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