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Protein

Single-stranded DNA-binding protein, mitochondrial

Gene

Ssbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA (By similarity).By similarity

GO - Molecular functioni

  • chromatin binding Source: UniProtKB
  • single-stranded DNA binding Source: GO_Central

GO - Biological processi

  • mitochondrial DNA replication Source: GO_Central
  • mitochondrion morphogenesis Source: MGI
  • positive regulation of helicase activity Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
Single-stranded DNA-binding protein, mitochondrial
Short name:
Mt-SSB
Short name:
MtSSB
Gene namesi
Name:Ssbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1920040 Ssbp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 16MitochondrionBy similarityAdd BLAST16
ChainiPRO_000003326417 – 152Single-stranded DNA-binding protein, mitochondrialAdd BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67PhosphoserineCombined sources1
Modified residuei79PhosphoserineBy similarity1
Modified residuei113N6-acetyllysineBy similarity1
Modified residuei122N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CYR0
MaxQBiQ9CYR0
PaxDbiQ9CYR0
PeptideAtlasiQ9CYR0
PRIDEiQ9CYR0

PTM databases

iPTMnetiQ9CYR0
PhosphoSitePlusiQ9CYR0

Expressioni

Gene expression databases

BgeeiENSMUSG00000029911 Expressed in 151 organ(s), highest expression level in female gonad
CleanExiMM_SSBP1
ExpressionAtlasiQ9CYR0 baseline and differential
GenevisibleiQ9CYR0 MM

Interactioni

Subunit structurei

Homotetramer. Interacts with MPG/AAG, through inhibition of its glycosylase activity it potentially prevents formation of DNA breaks in ssDNA, ensuring that base removal primarily occurs in dsDNA.By similarity

Protein-protein interaction databases

IntActiQ9CYR0, 1 interactor
STRINGi10090.ENSMUSP00000031971

Structurei

3D structure databases

ProteinModelPortaliQ9CYR0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 141SSBAdd BLAST112

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1653 Eukaryota
COG0629 LUCA
GeneTreeiENSGT00390000002796
HOGENOMiHOG000106484
HOVERGENiHBG001181
InParanoidiQ9CYR0
KOiK03111
OrthoDBiEOG091G1330
PhylomeDBiQ9CYR0
TreeFamiTF314629

Family and domain databases

CDDicd04496 SSB_OBF, 1 hit
HAMAPiMF_00984 SSB, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR000424 Primosome_PriB/ssb
IPR011344 ssDNA-bd
PANTHERiPTHR10302 PTHR10302, 1 hit
PTHR10302:SF0 PTHR10302:SF0, 1 hit
PfamiView protein in Pfam
PF00436 SSB, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00621 ssb, 1 hit
PROSITEiView protein in PROSITE
PS50935 SSB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9CYR0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRRPVLQVF RQFVRHESEV ASSLVLERSL NRVQLLGRVG QDPVMRQVEG
60 70 80 90 100
KNPVTIFSLA TNEMWRSGDS EVYQMGDVSQ KTTWHRISVF RPGLRDVAYQ
110 120 130 140 150
YVKKGARIFV EGKVDYGEYM DKNNVRRQAT TIIAGKKLVV HSVSGCSLEG

LA
Length:152
Mass (Da):17,319
Last modified:June 1, 2001 - v1
Checksum:i719B9F03C4C0D1EE
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8R2K3Q8R2K3_MOUSE
Single-stranded DNA binding protein...
Ssbp1 mCG_15097
148Annotation score:
D3Z3Y3D3Z3Y3_MOUSE
Single-stranded DNA-binding protein...
Ssbp1
76Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013425 mRNA Translation: BAB28850.1
CCDSiCCDS20030.1
RefSeqiNP_082634.1, NM_028358.2
NP_997633.1, NM_212468.3
XP_006506392.1, XM_006506329.2
XP_017177153.1, XM_017321664.1
UniGeneiMm.276356
Mm.393562

Genome annotation databases

EnsembliENSMUST00000031971; ENSMUSP00000031971; ENSMUSG00000029911
GeneIDi381760
KEGGimmu:381760
UCSCiuc009bmr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013425 mRNA Translation: BAB28850.1
CCDSiCCDS20030.1
RefSeqiNP_082634.1, NM_028358.2
NP_997633.1, NM_212468.3
XP_006506392.1, XM_006506329.2
XP_017177153.1, XM_017321664.1
UniGeneiMm.276356
Mm.393562

3D structure databases

ProteinModelPortaliQ9CYR0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CYR0, 1 interactor
STRINGi10090.ENSMUSP00000031971

PTM databases

iPTMnetiQ9CYR0
PhosphoSitePlusiQ9CYR0

Proteomic databases

EPDiQ9CYR0
MaxQBiQ9CYR0
PaxDbiQ9CYR0
PeptideAtlasiQ9CYR0
PRIDEiQ9CYR0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031971; ENSMUSP00000031971; ENSMUSG00000029911
GeneIDi381760
KEGGimmu:381760
UCSCiuc009bmr.1 mouse

Organism-specific databases

CTDi6742
MGIiMGI:1920040 Ssbp1

Phylogenomic databases

eggNOGiKOG1653 Eukaryota
COG0629 LUCA
GeneTreeiENSGT00390000002796
HOGENOMiHOG000106484
HOVERGENiHBG001181
InParanoidiQ9CYR0
KOiK03111
OrthoDBiEOG091G1330
PhylomeDBiQ9CYR0
TreeFamiTF314629

Miscellaneous databases

PROiPR:Q9CYR0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029911 Expressed in 151 organ(s), highest expression level in female gonad
CleanExiMM_SSBP1
ExpressionAtlasiQ9CYR0 baseline and differential
GenevisibleiQ9CYR0 MM

Family and domain databases

CDDicd04496 SSB_OBF, 1 hit
HAMAPiMF_00984 SSB, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR000424 Primosome_PriB/ssb
IPR011344 ssDNA-bd
PANTHERiPTHR10302 PTHR10302, 1 hit
PTHR10302:SF0 PTHR10302:SF0, 1 hit
PfamiView protein in Pfam
PF00436 SSB, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00621 ssb, 1 hit
PROSITEiView protein in PROSITE
PS50935 SSB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSSBP_MOUSE
AccessioniPrimary (citable) accession number: Q9CYR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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