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Protein

Renin receptor

Gene

Atp6ap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-2022377 Metabolism of Angiotensinogen to Angiotensins
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Renin receptor
Alternative name(s):
ATPase H(+)-transporting lysosomal accessory protein 2
ATPase H(+)-transporting lysosomal-interacting protein 2
Renin/prorenin receptor
Gene namesi
Name:Atp6ap2
Synonyms:Atp6ip2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1917745 Atp6ap2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 302ExtracellularSequence analysisAdd BLAST285
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Topological domaini324 – 350CytoplasmicSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002220418 – 350Renin receptorAdd BLAST333

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CYN9
MaxQBiQ9CYN9
PaxDbiQ9CYN9
PeptideAtlasiQ9CYN9
PRIDEiQ9CYN9
TopDownProteomicsiQ9CYN9

PTM databases

iPTMnetiQ9CYN9
PhosphoSitePlusiQ9CYN9

Expressioni

Gene expression databases

BgeeiENSMUSG00000031007 Expressed in 292 organ(s), highest expression level in conjunctival fornix
ExpressionAtlasiQ9CYN9 baseline and differential
GenevisibleiQ9CYN9 MM

Interactioni

Subunit structurei

Interacts with renin and the vacuolar proton-ATPase.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi214094, 2 interactors
IntActiQ9CYN9, 1 interactor
MINTiQ9CYN9
STRINGi10090.ENSMUSP00000033313

Structurei

3D structure databases

ProteinModelPortaliQ9CYN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4737 Eukaryota
ENOG4111F0U LUCA
GeneTreeiENSGT00390000008856
HOGENOMiHOG000232083
HOVERGENiHBG056579
InParanoidiQ9CYN9
KOiK19514
OMAiFRDGNWP
OrthoDBiEOG091G0HQ3
PhylomeDBiQ9CYN9
TreeFamiTF106137

Family and domain databases

InterProiView protein in InterPro
IPR012493 Renin_rcpt
PANTHERiPTHR13351 PTHR13351, 1 hit
PfamiView protein in Pfam
PF07850 Renin_r, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CYN9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVLVVLLFF LVAGALGNEF SILRSPGSVV FRNGNWPIPG DRIPDVAALS
60 70 80 90 100
MGFSVKEDLS WPGLAVGNLF HRPRATIMVM VKGVDKLALP AGSVISYPLE
110 120 130 140 150
NAVPFSLDSV ANSIHSLFSE ETPVVLQLAP SEERVYMVGK ANSVFEDLSV
160 170 180 190 200
TLRQLRNRLF QENSLLNSLP LNSLSRNNEV DLLFLSELQV LHDISSLLSR
210 220 230 240 250
HKHLAKDHSP DLYSLELAGL DELGKRYGED SEQFRDASKI LVDALQKFAD
260 270 280 290 300
DMYSLYGGNA VVELVTVKSF DTSLVRKSRT ILEAKQENTQ SPYNLAYKYN
310 320 330 340 350
LEYSVVFNLV LWIMIGLALA VIITSYNIWN MDPGYDSIIY RMTNQKIRID
Length:350
Mass (Da):39,092
Last modified:March 1, 2003 - v2
Checksum:i3A90E0C586E7BAC7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti157N → K in BAC36365 (PubMed:16141072).Curated1
Sequence conflicti169L → H in BAC36365 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017482 mRNA Translation: BAB30766.2
AK029405 mRNA Translation: BAC26436.1
AK076495 mRNA Translation: BAC36365.1
BX000537 Genomic DNA No translation available.
BC014706 mRNA Translation: AAH14706.1
CCDSiCCDS30023.1
RefSeqiNP_081715.1, NM_027439.4
UniGeneiMm.25148

Genome annotation databases

EnsembliENSMUST00000033313; ENSMUSP00000033313; ENSMUSG00000031007
GeneIDi70495
KEGGimmu:70495
UCSCiuc009sqx.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRENR_MOUSE
AccessioniPrimary (citable) accession number: Q9CYN9
Secondary accession number(s): A2BDN5, Q8BVU6, Q91YU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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