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Protein

Putative RNA-binding protein Luc7-like 1

Gene

Luc7l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May bind to RNA via its Arg/Ser-rich domain.

GO - Molecular functioni

  • identical protein binding Source: MGI
  • mRNA binding Source: GO_Central
  • RS domain binding Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Putative RNA-binding protein Luc7-like 1
Gene namesi
Name:Luc7l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1914228 Luc7l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001872811 – 371Putative RNA-binding protein Luc7-like 1Add BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei336PhosphoserineBy similarity1
Modified residuei363PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CYI4
PaxDbiQ9CYI4
PeptideAtlasiQ9CYI4
PRIDEiQ9CYI4

PTM databases

iPTMnetiQ9CYI4
PhosphoSitePlusiQ9CYI4

Expressioni

Gene expression databases

BgeeiENSMUSG00000024188 Expressed in 281 organ(s), highest expression level in female gonad
CleanExiMM_LUC7L
ExpressionAtlasiQ9CYI4 baseline and differential
GenevisibleiQ9CYI4 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211851, 3 interactors
IntActiQ9CYI4, 1 interactor
MINTiQ9CYI4
STRINGi10090.ENSMUSP00000110627

Structurei

3D structure databases

ProteinModelPortaliQ9CYI4
SMRiQ9CYI4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili87 – 177Sequence analysisAdd BLAST91
Coiled coili220 – 256Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi239 – 344Arg/Ser-richAdd BLAST106

Sequence similaritiesi

Belongs to the Luc7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0796 Eukaryota
COG5200 LUCA
GeneTreeiENSGT00730000110670
HOGENOMiHOG000215956
HOVERGENiHBG062167
InParanoidiQ9CYI4
OrthoDBiEOG091G0PSO
PhylomeDBiQ9CYI4
TreeFamiTF317607

Family and domain databases

InterProiView protein in InterPro
IPR004882 Luc7-rel
PANTHERiPTHR12375 PTHR12375, 1 hit
PfamiView protein in Pfam
PF03194 LUC7, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9CYI4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAQAQMRAL LDQLMGTARD GDETRQRVKF TDDRVCKSHL LDCCPHDILA
60 70 80 90 100
GTRMDLGECT KIHDLALRAD YEIASKERDL FFELDAMDHL ESFIAECDRR
110 120 130 140 150
TELAKKRLAE TQEEISAEVS AKAEKVHELN EEIGKLLAKA EQLGAEGNVD
160 170 180 190 200
ESQKILMEVE KVRAKKKEAE EEYRNSMPAS SFQQQKLRVC EVCSAYLGLH
210 220 230 240 250
DNDRRLADHF GGKLHLGFIQ IREKLDQLRK TVAEKQEKRN QDRLRRREER
260 270 280 290 300
EREERLGRRS GSRTRDRRRS RSRDRRRRRS RSTSRERRKF SRSRSRDRYR
310 320 330 340 350
RHRSRSRSHS RGHRRASRDR STKYKFSRER SLREESWEYG RNERGPTDWR
360 370
LENSNGKTAS RRSEEKEAGE I
Length:371
Mass (Da):43,934
Last modified:May 10, 2004 - v2
Checksum:iD63AC7111F855F4F
GO
Isoform 2 (identifier: Q9CYI4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Note: No experimental confirmation available.
Show »
Length:318
Mass (Da):37,976
Checksum:i11C8D6EFC856C6B5
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z765D3Z765_MOUSE
Putative RNA-binding protein Luc7-l...
Luc7l
172Annotation score:
D3YZ82D3YZ82_MOUSE
Putative RNA-binding protein Luc7-l...
Luc7l
69Annotation score:
A0A0R4J047A0A0R4J047_MOUSE
Luc7 homolog (S. cerevisiae)-like, ...
Luc7l mCG_49994
325Annotation score:
F6QU81F6QU81_MOUSE
Putative RNA-binding protein Luc7-l...
Luc7l
170Annotation score:
D6RGP6D6RGP6_MOUSE
Putative RNA-binding protein Luc7-l...
Luc7l
79Annotation score:
D6REI1D6REI1_MOUSE
Putative RNA-binding protein Luc7-l...
Luc7l
70Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti213K → E in BAB30856 (PubMed:16141072).Curated1
Sequence conflicti224 – 226KLD → SLI in BAB30856 (PubMed:16141072).Curated3
Sequence conflicti289K → R in BAB30856 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0102161 – 53Missing in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010539 mRNA Translation: BAB27015.1
AK017655 mRNA Translation: BAB30856.1
BC034135 mRNA Translation: AAH34135.1
CCDSiCCDS28549.1 [Q9CYI4-1]
RefSeqiNP_080157.1, NM_025881.3
NP_082466.2, NM_028190.3 [Q9CYI4-1]
XP_017173104.1, XM_017317615.1 [Q9CYI4-2]
UniGeneiMm.440216

Genome annotation databases

EnsembliENSMUST00000114976; ENSMUSP00000110627; ENSMUSG00000024188 [Q9CYI4-1]
GeneIDi66978
KEGGimmu:66978
UCSCiuc008bdy.2 mouse [Q9CYI4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010539 mRNA Translation: BAB27015.1
AK017655 mRNA Translation: BAB30856.1
BC034135 mRNA Translation: AAH34135.1
CCDSiCCDS28549.1 [Q9CYI4-1]
RefSeqiNP_080157.1, NM_025881.3
NP_082466.2, NM_028190.3 [Q9CYI4-1]
XP_017173104.1, XM_017317615.1 [Q9CYI4-2]
UniGeneiMm.440216

3D structure databases

ProteinModelPortaliQ9CYI4
SMRiQ9CYI4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211851, 3 interactors
IntActiQ9CYI4, 1 interactor
MINTiQ9CYI4
STRINGi10090.ENSMUSP00000110627

PTM databases

iPTMnetiQ9CYI4
PhosphoSitePlusiQ9CYI4

Proteomic databases

EPDiQ9CYI4
PaxDbiQ9CYI4
PeptideAtlasiQ9CYI4
PRIDEiQ9CYI4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114976; ENSMUSP00000110627; ENSMUSG00000024188 [Q9CYI4-1]
GeneIDi66978
KEGGimmu:66978
UCSCiuc008bdy.2 mouse [Q9CYI4-1]

Organism-specific databases

CTDi55692
MGIiMGI:1914228 Luc7l

Phylogenomic databases

eggNOGiKOG0796 Eukaryota
COG5200 LUCA
GeneTreeiENSGT00730000110670
HOGENOMiHOG000215956
HOVERGENiHBG062167
InParanoidiQ9CYI4
OrthoDBiEOG091G0PSO
PhylomeDBiQ9CYI4
TreeFamiTF317607

Miscellaneous databases

ChiTaRSiLuc7l mouse
PROiPR:Q9CYI4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024188 Expressed in 281 organ(s), highest expression level in female gonad
CleanExiMM_LUC7L
ExpressionAtlasiQ9CYI4 baseline and differential
GenevisibleiQ9CYI4 MM

Family and domain databases

InterProiView protein in InterPro
IPR004882 Luc7-rel
PANTHERiPTHR12375 PTHR12375, 1 hit
PfamiView protein in Pfam
PF03194 LUC7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLUC7L_MOUSE
AccessioniPrimary (citable) accession number: Q9CYI4
Secondary accession number(s): Q8K247, Q9CWM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: November 7, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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