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Entry version 137 (16 Oct 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Ribosome biogenesis regulatory protein homolog

Gene

Rrs1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRibosome biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribosome biogenesis regulatory protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rrs1
Synonyms:Rrr
ORF Names:MNCb-2643
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1929721 Rrs1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001853751 – 365Ribosome biogenesis regulatory protein homologAdd BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki226Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei273Citrulline1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Citrullinated by PADI4.1 Publication

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9CYH6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9CYH6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9CYH6

PeptideAtlas

More...
PeptideAtlasi
Q9CYH6

PRoteomics IDEntifications database

More...
PRIDEi
Q9CYH6

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9CYH6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9CYH6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9CYH6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9CYH6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000061024 Expressed in 88 organ(s), highest expression level in epiblast (generic)

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9CYH6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
208485, 3 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9CYH6

Protein interaction database and analysis system

More...
IntActi
Q9CYH6, 1 interactor

Molecular INTeraction database

More...
MINTi
Q9CYH6

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000071955

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9CYH6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi302 – 365Arg/Gly/Lys-richAdd BLAST64

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRS1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1765 Eukaryota
COG5225 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005213

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9CYH6

KEGG Orthology (KO)

More...
KOi
K14852

Identification of Orthologs from Complete Genome Data

More...
OMAi
RRWGYKR

Database of Orthologous Groups

More...
OrthoDBi
1264304at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9CYH6

TreeFam database of animal gene trees

More...
TreeFami
TF313067

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007023 Ribosom_reg

The PANTHER Classification System

More...
PANTHERi
PTHR17602 PTHR17602, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04939 RRS1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9CYH6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGQRVEELL AKAEQEEAEK LQRITVHKEL ELEFDLGNLL ASDRNPPTVL
60 70 80 90 100
RQAGPSPEAE LRALARDNTQ LLINQLWRLP TERVEEAVVA RLPEPATRLP
110 120 130 140 150
REKPLPRPRP LTRWQQFARL KGIRPKKKTN LVWDEASGQW RRRWGYKRAR
160 170 180 190 200
DDTKEWLIEV PGSADPMEDQ FAKRTQAKKE RVAKNELNRL RNLARAHKMQ
210 220 230 240 250
MPSSAGLHPT GHQSKEELGR AMQVAKVSTA SVGRFQERLP KEKAPRGSGK
260 270 280 290 300
KRKFQPLFGD FAAEKKNQLE LLRVMNSKKP RLDVTRATNK QMREEDQEEA
310 320 330 340 350
AKRRKMSQKG KRKGGRQGPS GKRKGGPPGQ GEKRKGGLGS KKHSWPSALA
360
GKKKGVPPQG GKRRK
Length:365
Mass (Da):41,552
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA99BDE7321652E66
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti135E → V in BAB26750 (PubMed:16141072).Curated1
Sequence conflicti185N → G in BAB31912 (PubMed:16141072).Curated1
Sequence conflicti324K → R in BAA95072 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB041589 mRNA Translation: BAA95072.1
AK010178 mRNA Translation: BAB26750.1
AK017683 mRNA Translation: BAB30871.1
AK019257 mRNA Translation: BAB31631.1
AK019913 mRNA Translation: BAB31912.1
AK142041 mRNA Translation: BAE24922.1
BC003481 mRNA Translation: AAH03481.1
BC055925 mRNA Translation: AAH55925.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14811.1

NCBI Reference Sequences

More...
RefSeqi
NP_067486.2, NM_021511.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000072079; ENSMUSP00000071955; ENSMUSG00000061024

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
59014

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:59014

UCSC genome browser

More...
UCSCi
uc007agk.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041589 mRNA Translation: BAA95072.1
AK010178 mRNA Translation: BAB26750.1
AK017683 mRNA Translation: BAB30871.1
AK019257 mRNA Translation: BAB31631.1
AK019913 mRNA Translation: BAB31912.1
AK142041 mRNA Translation: BAE24922.1
BC003481 mRNA Translation: AAH03481.1
BC055925 mRNA Translation: AAH55925.1
CCDSiCCDS14811.1
RefSeqiNP_067486.2, NM_021511.2

3D structure databases

SMRiQ9CYH6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi208485, 3 interactors
CORUMiQ9CYH6
IntActiQ9CYH6, 1 interactor
MINTiQ9CYH6
STRINGi10090.ENSMUSP00000071955

PTM databases

iPTMnetiQ9CYH6
PhosphoSitePlusiQ9CYH6
SwissPalmiQ9CYH6

Proteomic databases

EPDiQ9CYH6
MaxQBiQ9CYH6
PaxDbiQ9CYH6
PeptideAtlasiQ9CYH6
PRIDEiQ9CYH6
TopDownProteomicsiQ9CYH6

Genome annotation databases

EnsembliENSMUST00000072079; ENSMUSP00000071955; ENSMUSG00000061024
GeneIDi59014
KEGGimmu:59014
UCSCiuc007agk.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23212
MGIiMGI:1929721 Rrs1

Phylogenomic databases

eggNOGiKOG1765 Eukaryota
COG5225 LUCA
GeneTreeiENSGT00390000005213
InParanoidiQ9CYH6
KOiK14852
OMAiRRWGYKR
OrthoDBi1264304at2759
PhylomeDBiQ9CYH6
TreeFamiTF313067

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Rrs1 mouse

Protein Ontology

More...
PROi
PR:Q9CYH6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000061024 Expressed in 88 organ(s), highest expression level in epiblast (generic)
GenevisibleiQ9CYH6 MM

Family and domain databases

InterProiView protein in InterPro
IPR007023 Ribosom_reg
PANTHERiPTHR17602 PTHR17602, 1 hit
PfamiView protein in Pfam
PF04939 RRS1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRRS1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9CYH6
Secondary accession number(s): Q3UQW6
, Q9CS27, Q9D2B2, Q9D6M6, Q9JJC1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 1, 2001
Last modified: October 16, 2019
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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