UniProtKB - Q9CYH2 (PXL2A_MOUSE)
Protein
Peroxiredoxin-like 2A
Gene
Prxl2a
Organism
Mus musculus (Mouse)
Status
Functioni
Involved in redox regulation of the cell (By similarity). Acts as an antioxidant (By similarity). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (By similarity). May affect bone resorption and help to maintain bone mass (By similarity). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880).By similarity1 Publication
Miscellaneous
The active site cysteines correspond to the redox-active cysteines of peroxiredoxins.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 74 | Redox-activeBy similarity | 1 | |
Active sitei | 77 | Redox-activeBy similarity | 1 |
GO - Molecular functioni
- antioxidant activity Source: MGI
GO - Biological processi
- oxidation-reduction process Source: MGI
- regulation of osteoclast differentiation Source: MGI
Keywordsi
Molecular function | Antioxidant |
Names & Taxonomyi
Protein namesi | Recommended name: Peroxiredoxin-like 2ACuratedAlternative name(s): Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes2 Publications Short name: Protein PAMM2 Publications Redox-regulatory protein FAM213A |
Gene namesi | Name:Prxl2a Synonyms:Fam213aImported, Pamm2 Publications |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1917814, Prxl2a |
Subcellular locationi
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Mitochondrion
- mitochondrion Source: MGI
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
Cytoplasm, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000019551 | 1 – 218 | Peroxiredoxin-like 2AAdd BLAST | 218 |
Proteomic databases
EPDi | Q9CYH2 |
jPOSTi | Q9CYH2 |
MaxQBi | Q9CYH2 |
PaxDbi | Q9CYH2 |
PRIDEi | Q9CYH2 |
PTM databases
iPTMneti | Q9CYH2 |
PhosphoSitePlusi | Q9CYH2 |
SwissPalmi | Q9CYH2 |
Expressioni
Tissue specificityi
Expressed in kidney, liver, skin, and brain (PubMed:19951071). Widely expressed with highest levels detected in adipose tissue (PubMed:26438880).2 Publications
Gene expression databases
Bgeei | ENSMUSG00000021792, Expressed in uterine cervix and 330 other tissues |
ExpressionAtlasi | Q9CYH2, baseline and differential |
Genevisiblei | Q9CYH2, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 214138, 4 interactors |
IntActi | Q9CYH2, 1 interactor |
MINTi | Q9CYH2 |
STRINGi | 10090.ENSMUSP00000022317 |
Miscellaneous databases
RNActi | Q9CYH2, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 3 – 101 | Thioredoxin-like foldBy similarityAdd BLAST | 99 |
Sequence similaritiesi
Keywords - Domaini
Redox-active centerPhylogenomic databases
eggNOGi | KOG4498, Eukaryota |
GeneTreei | ENSGT00940000161199 |
InParanoidi | Q9CYH2 |
OrthoDBi | 1442607at2759 |
PhylomeDBi | Q9CYH2 |
TreeFami | TF313804 |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR032801, PXL2A/B/C IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR28630, PTHR28630, 1 hit |
Pfami | View protein in Pfam PF13911, AhpC-TSA_2, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
Q9CYH2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGMWSIGVGA VGAAAVALLL ANTDMFLSKP RKAALEYLED IDLKTLEKEP
60 70 80 90 100
RTFKAKELWE KNGAVIMAVR RPGCFLCRAE AADLMSLKPK LDELGVPLYA
110 120 130 140 150
VVKEQVKREV EDFQPYFKGE IFLDEKKKFY GPERRKMMFM GLIRLGVWYN
160 170 180 190 200
SFRAWNGGFS GNLEGEGFIL GGVFVIGSGK QGILLEHREK EFGDRVNPLS
210
VLEAVKKIKL QTPASGRS
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ3U125 | Q3U125_MOUSE | Peroxiredoxin-like 2A | Prxl2a 5730469M10Rik, Fam213a | 229 | Annotation score: | ||
D3Z252 | D3Z252_MOUSE | Peroxiredoxin-like 2A | Prxl2a 5730469M10Rik, Fam213a | 203 | Annotation score: | ||
D3YYG8 | D3YYG8_MOUSE | Peroxiredoxin-like 2A | Prxl2a 5730469M10Rik, Fam213a | 174 | Annotation score: | ||
D3Z0A8 | D3Z0A8_MOUSE | Peroxiredoxin-like 2A | Prxl2a 5730469M10Rik, Fam213a | 103 | Annotation score: | ||
D3Z398 | D3Z398_MOUSE | Peroxiredoxin-like 2A | Prxl2a 5730469M10Rik, Fam213a | 176 | Annotation score: | ||
D3YWL4 | D3YWL4_MOUSE | Peroxiredoxin-like 2A | Prxl2a 5730469M10Rik, Fam213a | 89 | Annotation score: | ||
D3Z143 | D3Z143_MOUSE | Peroxiredoxin-like 2A | Prxl2a 5730469M10Rik, Fam213a | 48 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK017688 mRNA Translation: BAB30875.2 BC056635 mRNA Translation: AAH56635.1 |
CCDSi | CCDS26957.1 |
RefSeqi | NP_001303661.1, NM_001316732.1 NP_001303662.1, NM_001316733.1 NP_001303663.1, NM_001316734.1 NP_001303664.1, NM_001316735.1 NP_001303665.1, NM_001316736.1 NP_001303666.1, NM_001316737.1 NP_001303668.1, NM_001316739.1 NP_001303669.1, NM_001316740.1 NP_081740.2, NM_027464.4 |
Genome annotation databases
Ensembli | ENSMUST00000022317; ENSMUSP00000022317; ENSMUSG00000021792 |
GeneIDi | 70564 |
KEGGi | mmu:70564 |
UCSCi | uc007tci.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK017688 mRNA Translation: BAB30875.2 BC056635 mRNA Translation: AAH56635.1 |
CCDSi | CCDS26957.1 |
RefSeqi | NP_001303661.1, NM_001316732.1 NP_001303662.1, NM_001316733.1 NP_001303663.1, NM_001316734.1 NP_001303664.1, NM_001316735.1 NP_001303665.1, NM_001316736.1 NP_001303666.1, NM_001316737.1 NP_001303668.1, NM_001316739.1 NP_001303669.1, NM_001316740.1 NP_081740.2, NM_027464.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 214138, 4 interactors |
IntActi | Q9CYH2, 1 interactor |
MINTi | Q9CYH2 |
STRINGi | 10090.ENSMUSP00000022317 |
PTM databases
iPTMneti | Q9CYH2 |
PhosphoSitePlusi | Q9CYH2 |
SwissPalmi | Q9CYH2 |
Proteomic databases
EPDi | Q9CYH2 |
jPOSTi | Q9CYH2 |
MaxQBi | Q9CYH2 |
PaxDbi | Q9CYH2 |
PRIDEi | Q9CYH2 |
Protocols and materials databases
Antibodypediai | 2394, 73 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000022317; ENSMUSP00000022317; ENSMUSG00000021792 |
GeneIDi | 70564 |
KEGGi | mmu:70564 |
UCSCi | uc007tci.1, mouse |
Organism-specific databases
CTDi | 84293 |
MGIi | MGI:1917814, Prxl2a |
Phylogenomic databases
eggNOGi | KOG4498, Eukaryota |
GeneTreei | ENSGT00940000161199 |
InParanoidi | Q9CYH2 |
OrthoDBi | 1442607at2759 |
PhylomeDBi | Q9CYH2 |
TreeFami | TF313804 |
Miscellaneous databases
BioGRID-ORCSi | 70564, 0 hits in 12 CRISPR screens |
ChiTaRSi | Fam213a, mouse |
PROi | PR:Q9CYH2 |
RNActi | Q9CYH2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021792, Expressed in uterine cervix and 330 other tissues |
ExpressionAtlasi | Q9CYH2, baseline and differential |
Genevisiblei | Q9CYH2, MM |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR032801, PXL2A/B/C IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR28630, PTHR28630, 1 hit |
Pfami | View protein in Pfam PF13911, AhpC-TSA_2, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PXL2A_MOUSE | |
Accessioni | Q9CYH2Primary (citable) accession number: Q9CYH2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2005 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 122 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families