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Protein

Kinetochore-associated protein DSN1 homolog

Gene

Dsn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.By similarity

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • mitotic sister chromatid segregation Source: GO_Central

Keywordsi

Biological processCell cycle, Cell division, Chromosome partition, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-6798695 Neutrophil degranulation
R-MMU-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Recommended name:
Kinetochore-associated protein DSN1 homolog
Gene namesi
Name:Dsn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914184 Dsn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000794821 – 348Kinetochore-associated protein DSN1 homologAdd BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei79PhosphoserineBy similarity1
Modified residuei107PhosphoserineBy similarity1
Modified residuei123PhosphoserineBy similarity1
Cross-linki253Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei331PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CYC5
MaxQBiQ9CYC5
PaxDbiQ9CYC5
PeptideAtlasiQ9CYC5
PRIDEiQ9CYC5

PTM databases

iPTMnetiQ9CYC5
PhosphoSitePlusiQ9CYC5

Expressioni

Gene expression databases

BgeeiENSMUSG00000027635 Expressed in 209 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ9CYC5 baseline and differential
GenevisibleiQ9CYC5 MM

Interactioni

Subunit structurei

Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3 and CBX5. Interacts with KNSTRN.By similarity

Protein-protein interaction databases

BioGridi211821, 1 interactor
IntActiQ9CYC5, 2 interactors
MINTiQ9CYC5
STRINGi10090.ENSMUSP00000099418

Structurei

3D structure databases

SMRiQ9CYC5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IHC2 Eukaryota
ENOG410YXFH LUCA
GeneTreeiENSGT00390000011347
HOGENOMiHOG000231275
HOVERGENiHBG051208
InParanoidiQ9CYC5
KOiK11544
OMAiTHDHQLE
OrthoDBiEOG091G08B4
PhylomeDBiQ9CYC5
TreeFamiTF335504

Family and domain databases

InterProiView protein in InterPro
IPR013218 Dsn1/Mis13
PANTHERiPTHR14778 PTHR14778, 1 hit
PfamiView protein in Pfam
PF08202 MIS13, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9CYC5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSVTRSEDQ EPTMSETQDR PLQPSLKPLE ALPQSSAYQE MMTQGVSEEK
60 70 80 90 100
NHLGSNPGEG ESCGADHQEG SQLRSFHLSP QEQSIRPQDR RQSWRRASMK
110 120 130 140 150
EVNRRKSLAP FHPGITELCR SISVKLAQSQ RLGALLLSSF QFSVEKLEPF
160 170 180 190 200
LKNTKDFSLE CFRAKASSLS EELKHFTDRL GNDGTLQKCF VEDSKEKAAD
210 220 230 240 250
FSLEASVAEV KEYITKFSLE RQAWDRLLLQ YQNEVPPEEM PRGSTETRIT
260 270 280 290 300
EVKVDPAAYL RSSQKEVLST KPDYQRIVQD QNQVFAYVEL VMDELQGSVK
310 320 330 340
QLQALMDEST QYLQKVSVQL KKRSMDQLDS SPARKLLKLP LQSSPSTQ
Length:348
Mass (Da):39,553
Last modified:June 1, 2001 - v1
Checksum:i951795E67E65062E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ACV5A2ACV5_MOUSE
Kinetochore-associated protein DSN1...
Dsn1
232Annotation score:
B0QZT4B0QZT4_MOUSE
Kinetochore-associated protein DSN1...
Dsn1
124Annotation score:
B0QZT5B0QZT5_MOUSE
Kinetochore-associated protein DSN1...
Dsn1
65Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6R → G in BAB30906 (PubMed:16141072).Curated1
Sequence conflicti330S → T in BAB24479 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017813 mRNA Translation: BAB30950.1
AK006246 mRNA Translation: BAB24479.1
AK017740 mRNA Translation: BAB30906.1
BC025079 mRNA Translation: AAH25079.1
BC046807 mRNA Translation: AAH46807.1
CCDSiCCDS16972.1
RefSeqiNP_080129.2, NM_025853.3
UniGeneiMm.25410

Genome annotation databases

EnsembliENSMUST00000103129; ENSMUSP00000099418; ENSMUSG00000027635
ENSMUST00000103130; ENSMUSP00000099419; ENSMUSG00000027635
GeneIDi66934
KEGGimmu:66934
UCSCiuc008noj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017813 mRNA Translation: BAB30950.1
AK006246 mRNA Translation: BAB24479.1
AK017740 mRNA Translation: BAB30906.1
BC025079 mRNA Translation: AAH25079.1
BC046807 mRNA Translation: AAH46807.1
CCDSiCCDS16972.1
RefSeqiNP_080129.2, NM_025853.3
UniGeneiMm.25410

3D structure databases

SMRiQ9CYC5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211821, 1 interactor
IntActiQ9CYC5, 2 interactors
MINTiQ9CYC5
STRINGi10090.ENSMUSP00000099418

PTM databases

iPTMnetiQ9CYC5
PhosphoSitePlusiQ9CYC5

Proteomic databases

EPDiQ9CYC5
MaxQBiQ9CYC5
PaxDbiQ9CYC5
PeptideAtlasiQ9CYC5
PRIDEiQ9CYC5

Protocols and materials databases

DNASUi66934
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103129; ENSMUSP00000099418; ENSMUSG00000027635
ENSMUST00000103130; ENSMUSP00000099419; ENSMUSG00000027635
GeneIDi66934
KEGGimmu:66934
UCSCiuc008noj.2 mouse

Organism-specific databases

CTDi79980
MGIiMGI:1914184 Dsn1

Phylogenomic databases

eggNOGiENOG410IHC2 Eukaryota
ENOG410YXFH LUCA
GeneTreeiENSGT00390000011347
HOGENOMiHOG000231275
HOVERGENiHBG051208
InParanoidiQ9CYC5
KOiK11544
OMAiTHDHQLE
OrthoDBiEOG091G08B4
PhylomeDBiQ9CYC5
TreeFamiTF335504

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-6798695 Neutrophil degranulation
R-MMU-68877 Mitotic Prometaphase

Miscellaneous databases

PROiPR:Q9CYC5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027635 Expressed in 209 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ9CYC5 baseline and differential
GenevisibleiQ9CYC5 MM

Family and domain databases

InterProiView protein in InterPro
IPR013218 Dsn1/Mis13
PANTHERiPTHR14778 PTHR14778, 1 hit
PfamiView protein in Pfam
PF08202 MIS13, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDSN1_MOUSE
AccessioniPrimary (citable) accession number: Q9CYC5
Secondary accession number(s): Q9CYF2, Q9DA26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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