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Protein

Cysteine-rich with EGF-like domain protein 2

Gene

Creld2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate transport of alpha4-beta2 neuronal acetylcholine receptor.By similarity

GO - Molecular functioni

Keywordsi

LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich with EGF-like domain protein 2
Gene namesi
Name:Creld2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1923987 Creld2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000025624623 – 350Cysteine-rich with EGF-like domain protein 2Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi138 ↔ 152PROSITE-ProRule annotation
Disulfide bondi146 ↔ 164PROSITE-ProRule annotation
Disulfide bondi166 ↔ 175PROSITE-ProRule annotation
Glycosylationi249N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi292 ↔ 306PROSITE-ProRule annotation
Disulfide bondi299 ↔ 315PROSITE-ProRule annotation
Disulfide bondi317 ↔ 328PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9CYA0
MaxQBiQ9CYA0
PaxDbiQ9CYA0
PeptideAtlasiQ9CYA0
PRIDEiQ9CYA0

PTM databases

iPTMnetiQ9CYA0
PhosphoSitePlusiQ9CYA0

Expressioni

Gene expression databases

BgeeiENSMUSG00000023272 Expressed in 291 organ(s), highest expression level in prostate gland
CleanExiMM_CRELD2
GenevisibleiQ9CYA0 MM

Interactioni

Subunit structurei

May interact with CHRNA4.By similarity

Protein-protein interaction databases

IntActiQ9CYA0, 3 interactors
MINTiQ9CYA0
STRINGi10090.ENSMUSP00000024042

Structurei

3D structure databases

ProteinModelPortaliQ9CYA0
SMRiQ9CYA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 176EGF-like 1PROSITE-ProRule annotationAdd BLAST43
Repeati191 – 238FU 1Add BLAST48
Repeati251 – 298FU 2Add BLAST48
Domaini288 – 329EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST42

Sequence similaritiesi

Belongs to the CRELD family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG4260 Eukaryota
ENOG41107X2 LUCA
GeneTreeiENSGT00680000100014
HOGENOMiHOG000004778
HOVERGENiHBG081344
InParanoidiQ9CYA0
OMAiCVGCTGK
OrthoDBiEOG091G09AA
PhylomeDBiQ9CYA0
TreeFamiTF316507

Family and domain databases

CDDicd00064 FU, 2 hits
InterProiView protein in InterPro
IPR021852 DUF3456
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR006212 Furin_repeat
IPR009030 Growth_fac_rcpt_cys_sf
IPR002049 Laminin_EGF
PfamiView protein in Pfam
PF11938 DUF3456, 1 hit
PF07645 EGF_CA, 2 hits
SMARTiView protein in SMART
SM00181 EGF, 4 hits
SM00179 EGF_CA, 2 hits
SM00261 FU, 2 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CYA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHLLLAAAFG LLLLLPPPGA VASRKPTMCQ RCRTLVDKFN QGMANTARKN
60 70 80 90 100
FGGGNTAWEE KTLSKYEFSE IRLLEIMEGL CDSSDFECNQ LLEQQEEQLE
110 120 130 140 150
AWWQTLKKEH PNLFEWFCVH TLKACCLPGT YGPDCQECQG GSERPCSGNG
160 170 180 190 200
YCSGDGSRQG DGSCQCHTGY KGPLCIDCTD GFFSLQRNET HSICSACDES
210 220 230 240 250
CKTCSGPSNK DCIQCEVGWA RVEDACVDVD ECAAETSPCS DGQYCENVNG
260 270 280 290 300
SYTCEDCDST CVGCTGKGPA NCKECIAGYT KESGQCTDID ECSLEEKACK
310 320 330 340 350
RKNENCYNVP GSFVCVCPEG FEETEDACVQ TAEGKVTEEN PTQPPSREDL
Length:350
Mass (Da):38,220
Last modified:June 1, 2001 - v1
Checksum:i781D7389B1944231
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017880 mRNA Translation: BAB30986.1
AK165884 mRNA Translation: BAE38436.1
BC047370 mRNA Translation: AAH47370.1
CCDSiCCDS27733.1
RefSeqiNP_083996.1, NM_029720.2
UniGeneiMm.292567

Genome annotation databases

EnsembliENSMUST00000024042; ENSMUSP00000024042; ENSMUSG00000023272
GeneIDi76737
KEGGimmu:76737
UCSCiuc007xep.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017880 mRNA Translation: BAB30986.1
AK165884 mRNA Translation: BAE38436.1
BC047370 mRNA Translation: AAH47370.1
CCDSiCCDS27733.1
RefSeqiNP_083996.1, NM_029720.2
UniGeneiMm.292567

3D structure databases

ProteinModelPortaliQ9CYA0
SMRiQ9CYA0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CYA0, 3 interactors
MINTiQ9CYA0
STRINGi10090.ENSMUSP00000024042

PTM databases

iPTMnetiQ9CYA0
PhosphoSitePlusiQ9CYA0

Proteomic databases

EPDiQ9CYA0
MaxQBiQ9CYA0
PaxDbiQ9CYA0
PeptideAtlasiQ9CYA0
PRIDEiQ9CYA0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024042; ENSMUSP00000024042; ENSMUSG00000023272
GeneIDi76737
KEGGimmu:76737
UCSCiuc007xep.1 mouse

Organism-specific databases

CTDi79174
MGIiMGI:1923987 Creld2

Phylogenomic databases

eggNOGiKOG4260 Eukaryota
ENOG41107X2 LUCA
GeneTreeiENSGT00680000100014
HOGENOMiHOG000004778
HOVERGENiHBG081344
InParanoidiQ9CYA0
OMAiCVGCTGK
OrthoDBiEOG091G09AA
PhylomeDBiQ9CYA0
TreeFamiTF316507

Miscellaneous databases

ChiTaRSiCreld2 mouse
PROiPR:Q9CYA0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023272 Expressed in 291 organ(s), highest expression level in prostate gland
CleanExiMM_CRELD2
GenevisibleiQ9CYA0 MM

Family and domain databases

CDDicd00064 FU, 2 hits
InterProiView protein in InterPro
IPR021852 DUF3456
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR006212 Furin_repeat
IPR009030 Growth_fac_rcpt_cys_sf
IPR002049 Laminin_EGF
PfamiView protein in Pfam
PF11938 DUF3456, 1 hit
PF07645 EGF_CA, 2 hits
SMARTiView protein in SMART
SM00181 EGF, 4 hits
SM00179 EGF_CA, 2 hits
SM00261 FU, 2 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCREL2_MOUSE
AccessioniPrimary (citable) accession number: Q9CYA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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