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Protein

Biliverdin reductase A

Gene

Blvra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.By similarity

Miscellaneous

Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7). NADPH, however, is the probable reactant in biological systems (By similarity).By similarity

Catalytic activityi

Bilirubin + NAD(P)+ = biliverdin + NAD(P)H.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: protoheme degradation

This protein is involved in the pathway protoheme degradation, which is part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the pathway protoheme degradation and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei97NAD or NADP; via carbonyl oxygenBy similarity1
Metal bindingi279ZincSequence analysis1
Metal bindingi280ZincSequence analysis1
Metal bindingi291ZincSequence analysis1
Metal bindingi292ZincSequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 20NAD or NADPBy similarity6
Nucleotide bindingi76 – 79NAD or NADPBy similarity4

GO - Molecular functioni

  • biliverdin reductase activity Source: MGI
  • nucleotide binding Source: MGI
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-189483 Heme degradation
UniPathwayiUPA00684

Names & Taxonomyi

Protein namesi
Recommended name:
Biliverdin reductase A (EC:1.3.1.24)
Short name:
BVR A
Alternative name(s):
Biliverdin-IX alpha-reductase
Gene namesi
Name:Blvra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:88170 Blvra

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000108541 – 2By similarity2
ChainiPRO_00000108553 – 295Biliverdin reductase AAdd BLAST293

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei154PhosphoserineCombined sources1
Modified residuei173PhosphothreonineBy similarity1
Modified residuei177PhosphoserineBy similarity1
Modified residuei229PhosphoserineBy similarity1
Modified residuei247N6-acetyllysineBy similarity1
Modified residuei252N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CY64
MaxQBiQ9CY64
PaxDbiQ9CY64
PeptideAtlasiQ9CY64
PRIDEiQ9CY64

PTM databases

iPTMnetiQ9CY64
PhosphoSitePlusiQ9CY64
SwissPalmiQ9CY64

Expressioni

Gene expression databases

BgeeiENSMUSG00000001999
CleanExiMM_BLVRA
ExpressionAtlasiQ9CY64 baseline and differential
GenevisibleiQ9CY64 MM

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiQ9CY64, 2 interactors
MINTiQ9CY64
STRINGi10090.ENSMUSP00000002064

Structurei

3D structure databases

ProteinModelPortaliQ9CY64
SMRiQ9CY64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi11 – 16Poly-Val6

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IH7U Eukaryota
ENOG4111FZX LUCA
GeneTreeiENSGT00390000011072
HOGENOMiHOG000231884
HOVERGENiHBG003218
InParanoidiQ9CY64
KOiK00214
OMAiHVAFICT
OrthoDBiEOG091G0E2N
PhylomeDBiQ9CY64
TreeFamiTF342889

Family and domain databases

InterProiView protein in InterPro
IPR017094 Biliverdin_Rdtase_A
IPR015249 Biliverdin_Rdtase_cat
IPR036291 NAD(P)-bd_dom_sf
IPR000683 Oxidoreductase_N
PfamiView protein in Pfam
PF09166 Biliv-reduc_cat, 1 hit
PF01408 GFO_IDH_MocA, 1 hit
PIRSFiPIRSF037032 Biliverdin_reductase_A, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD040165 Biliverdin_Rdtase_cat, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CY64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTEPKRKFG VVVVGVGRAG SVRIRDLKDP HSSAFLNLIG YVSRRELGSL
60 70 80 90 100
DNVRQISLED ALRSQEVDVA YICTESSSHE DYIRQFLQAG KHVLVEYPMA
110 120 130 140 150
LSFAAAQELW ELAAQKGRVL HEEHIELLME EFEFLKREVA GKELLKGSLR
160 170 180 190 200
FTASPLEEEK FGFPAFSGIS RLTWLVSLFG ELSLISATME NRKEDQYMKM
210 220 230 240 250
TVQLETQNKS PLSWIEEKGP GLKRNRHISI HFKSGSLEEV PNVGVNKNIF
260 270 280 290
LKDQDIFIQK LLGQVSAEDL AAEKKRILHC LELASDIQRL CHRKQ
Length:295
Mass (Da):33,525
Last modified:June 1, 2001 - v1
Checksum:iF2E1682BD77032A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27L → S in AAH52146 (PubMed:15489334).Curated1
Sequence conflicti295Q → QWGGSFRYL in BAB21950 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002231 mRNA Translation: BAB21950.1
AK010847 mRNA Translation: BAB27219.1
AK172620 mRNA Translation: BAE43098.1
BC052146 mRNA Translation: AAH52146.1
CCDSiCCDS16692.1
RefSeqiNP_080954.4, NM_026678.4
XP_006498634.1, XM_006498571.3
XP_006498635.1, XM_006498572.3
UniGeneiMm.22028

Genome annotation databases

EnsembliENSMUST00000002064; ENSMUSP00000002064; ENSMUSG00000001999
GeneIDi109778
KEGGimmu:109778
UCSCiuc008meq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiBIEA_MOUSE
AccessioniPrimary (citable) accession number: Q9CY64
Secondary accession number(s): Q3T9C6, Q80WR6, Q9DD21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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