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Protein

Plasminogen activator inhibitor 1 RNA-binding protein

Gene

Serbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen activator inhibitor 1 RNA-binding protein
Alternative name(s):
PAI1 RNA-binding protein 1
Short name:
PAI-RBP1
SERPINE1 mRNA-binding protein 1
Gene namesi
Name:Serbp1
Synonyms:Pairbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1914120 Serbp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000581831 – 407Plasminogen activator inhibitor 1 RNA-binding proteinAdd BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineCombined sources1
Modified residuei52N6-acetyllysine; alternateCombined sources1
Cross-linki52Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Modified residuei68N6-acetyllysineBy similarity1
Cross-linki102Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei122N6-acetyllysineCombined sources1
Modified residuei140N6-acetyllysineBy similarity1
Modified residuei165Omega-N-methylarginineCombined sources1
Modified residuei188Omega-N-methylarginineCombined sources1
Modified residuei197PhosphoserineBy similarity1
Modified residuei203PhosphoserineBy similarity1
Modified residuei205PhosphoserineBy similarity1
Modified residuei208PhosphoserineBy similarity1
Modified residuei211N6-acetyllysine; alternateBy similarity1
Cross-linki211Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei216Omega-N-methylarginineCombined sources1
Modified residuei221PhosphoserineBy similarity1
Cross-linki228Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki228Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei234PhosphoserineCombined sources1
Cross-linki280Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei328N6-acetyllysineCombined sources1
Modified residuei329PhosphoserineCombined sources1
Modified residuei363Omega-N-methylarginineCombined sources1
Modified residuei366Omega-N-methylarginineCombined sources1
Modified residuei369Omega-N-methylarginineCombined sources1
Modified residuei391PhosphoserineCombined sources1
Modified residuei393PhosphoserineBy similarity1
Isoform 3 (identifier: Q9CY58-3)
Modified residuei231PhosphoserineCombined sources1
Modified residuei234PhosphothreonineCombined sources1
Isoform 2 (identifier: Q9CY58-2)
Modified residuei237PhosphoserineCombined sources1
Modified residuei240PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CY58
PaxDbiQ9CY58
PeptideAtlasiQ9CY58
PRIDEiQ9CY58
TopDownProteomicsiQ9CY58-1 [Q9CY58-1]
Q9CY58-3 [Q9CY58-3]

PTM databases

iPTMnetiQ9CY58
PhosphoSitePlusiQ9CY58
SwissPalmiQ9CY58

Expressioni

Gene expression databases

BgeeiENSMUSG00000036371 Expressed in 282 organ(s), highest expression level in primitive streak
CleanExiMM_SERBP1
ExpressionAtlasiQ9CY58 baseline and differential
GenevisibleiQ9CY58 MM

Interactioni

Subunit structurei

Interacts with SPIN1 (PubMed:23894536). Interacts with CHD3 and TDRD3. Interacts with ZDHHC17 (via ANK repeats) (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi211777, 4 interactors
IntActiQ9CY58, 7 interactors
MINTiQ9CY58
STRINGi10090.ENSMUSP00000039110

Structurei

3D structure databases

ProteinModelPortaliQ9CY58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2945 Eukaryota
ENOG410YBHR LUCA
GeneTreeiENSGT00520000055591
HOGENOMiHOG000220826
HOVERGENiHBG056357
InParanoidiQ9CY58
KOiK13199
OrthoDBiEOG091G0UA9
PhylomeDBiQ9CY58
TreeFamiTF318374

Family and domain databases

InterProiView protein in InterPro
IPR039764 HABP4/SERBP1
IPR006861 HABP4_PAIRBP1-bd
IPR032381 IHABP4_N
IPR027205 SERBP1
PANTHERiPTHR12299 PTHR12299, 1 hit
PTHR12299:SF29 PTHR12299:SF29, 1 hit
PfamiView protein in Pfam
PF04774 HABP4_PAI-RBP1, 1 hit
PF16174 IHABP4_N, 1 hit
SMARTiView protein in SMART
SM01233 HABP4_PAI-RBP1, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9CY58-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGHLQEGFG CVVTNRFDQL FDDESDPFEV LKAAENKKKE AGGGGVGGPG
60 70 80 90 100
AKSAAQAAAQ TNSNAAGKQL RKESQKDRKN PLPPSVGVAD KKEETQPPVA
110 120 130 140 150
LKKEGIRRVG RRPDQQLQGD GKLIDRRAER RPPRERRFEK PLEEKGEGGE
160 170 180 190 200
FSVDRPIIER PIRGRGGLGR GRGGRGRGMG RGDGFDSRGK REFDRHSGSD
210 220 230 240 250
RSSFSHYSGL KHEDKRGGSG SHNWGTVKDE LTESPKYIQK QISYNCSDLD
260 270 280 290 300
QSNVTEETPE GEEHPVADTE NKENEVEEVK EEGPKEMTLD EWKAIQNKDR
310 320 330 340 350
AKVEFNIRKP NEGADGQWKK GFVLHKSKSE EAHAEDSVMD HHFRKPANDI
360 370 380 390 400
TSQLEINFGD LGRPGRGGRG GRGGRGRGGR PNRGSRTDKS SASAPDVDDP

EAFPALA
Length:407
Mass (Da):44,714
Last modified:September 27, 2004 - v2
Checksum:iAC4F61EF7F38A8E5
GO
Isoform 2 (identifier: Q9CY58-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-247: Missing.

Show »
Length:392
Mass (Da):42,944
Checksum:i1569ACE4336B118B
GO
Isoform 3 (identifier: Q9CY58-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-208: Missing.
     233-247: Missing.

Show »
Length:386
Mass (Da):42,235
Checksum:iA22FB50BE68F72CB
GO
Isoform 4 (identifier: Q9CY58-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-235: ESP → LVF
     236-407: Missing.

Note: May be due to intron retention. No experimental confirmation available.
Show »
Length:235
Mass (Da):25,679
Checksum:i687C4A3292F7B607
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UMP4Q3UMP4_MOUSE
Plasminogen activator inhibitor 1 R...
Serbp1
401Annotation score:
A0A0N4SV32A0A0N4SV32_MOUSE
Plasminogen activator inhibitor 1 R...
Serbp1
362Annotation score:
A0A0N4SWH2A0A0N4SWH2_MOUSE
Plasminogen activator inhibitor 1 R...
Serbp1
211Annotation score:
A0A0N4SV40A0A0N4SV40_MOUSE
Plasminogen activator inhibitor 1 R...
Serbp1
186Annotation score:
A0A0N4SUN8A0A0N4SUN8_MOUSE
Plasminogen activator inhibitor 1 R...
Serbp1
155Annotation score:
A0A0N4SUQ1A0A0N4SUQ1_MOUSE
Plasminogen activator inhibitor 1 R...
Serbp1
147Annotation score:
A0A0N4SVK5A0A0N4SVK5_MOUSE
Plasminogen activator inhibitor 1 R...
Serbp1
75Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5L → P in BAC40253 (PubMed:16141072).Curated1
Sequence conflicti403F → S in BAB23466 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011632203 – 208Missing in isoform 3. 2 Publications6
Alternative sequenceiVSP_011633233 – 247Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_011634233 – 235ESP → LVF in isoform 4. 1 Publication3
Alternative sequenceiVSP_011635236 – 407Missing in isoform 4. 1 PublicationAdd BLAST172

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004678 mRNA Translation: BAB23466.1
AK010860 mRNA Translation: BAB27229.1
AK012390 mRNA Translation: BAB28207.1
AK045190 mRNA Translation: BAC32255.1
AK088278 mRNA Translation: BAC40253.1
BC013665 mRNA Translation: AAH13665.1
BC030502 mRNA Translation: AAH30502.1
CCDSiCCDS20219.1 [Q9CY58-1]
CCDS85060.1 [Q9CY58-2]
CCDS85062.1 [Q9CY58-3]
RefSeqiNP_001107037.1, NM_001113565.1 [Q9CY58-2]
NP_001107038.1, NM_001113566.1 [Q9CY58-3]
NP_080090.2, NM_025814.2 [Q9CY58-1]
UniGeneiMm.240490
Mm.440861

Genome annotation databases

EnsembliENSMUST00000042990; ENSMUSP00000039110; ENSMUSG00000036371 [Q9CY58-1]
ENSMUST00000203077; ENSMUSP00000144913; ENSMUSG00000036371 [Q9CY58-2]
ENSMUST00000204293; ENSMUSP00000145472; ENSMUSG00000036371 [Q9CY58-3]
GeneIDi66870
KEGGimmu:66870
UCSCiuc009cfh.1 mouse [Q9CY58-2]
uc009cfi.1 mouse [Q9CY58-4]
uc009cfj.2 mouse [Q9CY58-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004678 mRNA Translation: BAB23466.1
AK010860 mRNA Translation: BAB27229.1
AK012390 mRNA Translation: BAB28207.1
AK045190 mRNA Translation: BAC32255.1
AK088278 mRNA Translation: BAC40253.1
BC013665 mRNA Translation: AAH13665.1
BC030502 mRNA Translation: AAH30502.1
CCDSiCCDS20219.1 [Q9CY58-1]
CCDS85060.1 [Q9CY58-2]
CCDS85062.1 [Q9CY58-3]
RefSeqiNP_001107037.1, NM_001113565.1 [Q9CY58-2]
NP_001107038.1, NM_001113566.1 [Q9CY58-3]
NP_080090.2, NM_025814.2 [Q9CY58-1]
UniGeneiMm.240490
Mm.440861

3D structure databases

ProteinModelPortaliQ9CY58
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211777, 4 interactors
IntActiQ9CY58, 7 interactors
MINTiQ9CY58
STRINGi10090.ENSMUSP00000039110

PTM databases

iPTMnetiQ9CY58
PhosphoSitePlusiQ9CY58
SwissPalmiQ9CY58

Proteomic databases

EPDiQ9CY58
PaxDbiQ9CY58
PeptideAtlasiQ9CY58
PRIDEiQ9CY58
TopDownProteomicsiQ9CY58-1 [Q9CY58-1]
Q9CY58-3 [Q9CY58-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042990; ENSMUSP00000039110; ENSMUSG00000036371 [Q9CY58-1]
ENSMUST00000203077; ENSMUSP00000144913; ENSMUSG00000036371 [Q9CY58-2]
ENSMUST00000204293; ENSMUSP00000145472; ENSMUSG00000036371 [Q9CY58-3]
GeneIDi66870
KEGGimmu:66870
UCSCiuc009cfh.1 mouse [Q9CY58-2]
uc009cfi.1 mouse [Q9CY58-4]
uc009cfj.2 mouse [Q9CY58-1]

Organism-specific databases

CTDi26135
MGIiMGI:1914120 Serbp1

Phylogenomic databases

eggNOGiKOG2945 Eukaryota
ENOG410YBHR LUCA
GeneTreeiENSGT00520000055591
HOGENOMiHOG000220826
HOVERGENiHBG056357
InParanoidiQ9CY58
KOiK13199
OrthoDBiEOG091G0UA9
PhylomeDBiQ9CY58
TreeFamiTF318374

Miscellaneous databases

ChiTaRSiSerbp1 mouse
PROiPR:Q9CY58
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036371 Expressed in 282 organ(s), highest expression level in primitive streak
CleanExiMM_SERBP1
ExpressionAtlasiQ9CY58 baseline and differential
GenevisibleiQ9CY58 MM

Family and domain databases

InterProiView protein in InterPro
IPR039764 HABP4/SERBP1
IPR006861 HABP4_PAIRBP1-bd
IPR032381 IHABP4_N
IPR027205 SERBP1
PANTHERiPTHR12299 PTHR12299, 1 hit
PTHR12299:SF29 PTHR12299:SF29, 1 hit
PfamiView protein in Pfam
PF04774 HABP4_PAI-RBP1, 1 hit
PF16174 IHABP4_N, 1 hit
SMARTiView protein in SMART
SM01233 HABP4_PAI-RBP1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAIRB_MOUSE
AccessioniPrimary (citable) accession number: Q9CY58
Secondary accession number(s): Q8BHS2
, Q8BHU0, Q91WP3, Q9CSN0, Q9DBY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: November 7, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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