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Entry version 124 (16 Oct 2019)
Sequence version 2 (01 Mar 2003)
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Protein

Chromatin target of PRMT1 protein

Gene

Chtop

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in the ligand-dependent activation of estrogen receptor target genes (By similarity). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC methylates H4R3 and transactivates genes involved in glioblastomagenesis (PubMed:25284789).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-72187 mRNA 3'-end processing
R-MMU-73856 RNA Polymerase II Transcription Termination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromatin target of PRMT1 protein
Alternative name(s):
Friend of PRMT1 protein
Small arginine- and glycine-rich protein
Short name:
SRAG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Chtop
Synonyms:Fop
ORF Names:MNCb-1706
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1913761 Chtop

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000892642 – 249Chromatin target of PRMT1 proteinAdd BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei40PhosphoserineBy similarity1
Modified residuei49PhosphoserineBy similarity1
Modified residuei64PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki70Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei243PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Asymmetrically methylated by PRMT1. Symmetrically methylated by PRMT5.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9CY57

PRoteomics IDEntifications database

More...
PRIDEi
Q9CY57

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9CY57

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9CY57

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9CY57

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed with highest levels found in thymus, spleen, and lymph nodes. Expressed in an erythroid progenitor cell line derived from fetal liver.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Broadly expressed at 16.5 dpc.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000001017 Expressed in 295 organ(s), highest expression level in saccule of membranous labyrinth

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9CY57 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9CY57 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PRMT1 and PRMT5 (PubMed:19858291, PubMed:22872859).

Interacts with the 5FMC complex; the interaction is methylation-dependent.

Interacts with FYTTD1, SET and PRC1 complex members CBX4, RNF2 and PHC2; the interactions are methylation-independent.

Interacts with ZNF148 (PubMed:22872859).

Interacts with WDR77 and ERH (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
211527, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q9CY57, 11 interactors

Molecular INTeraction database

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MINTi
Q9CY57

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000001043

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9CY57

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni154 – 207Interaction with PRMT1Add BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi195 – 204GAR motif; involved in 5hmC bindingBy similarity10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi88 – 209Arg/Gly-richAdd BLAST122

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IWUS Eukaryota
ENOG4111XP9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002869

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9CY57

Identification of Orthologs from Complete Genome Data

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OMAi
RFTNMMK

Database of Orthologous Groups

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OrthoDBi
1598721at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9CY57

TreeFam database of animal gene trees

More...
TreeFami
TF331447

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR025715 FoP_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13865 FoP_duplication, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01218 FoP_duplication, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9CY57-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAQSAPKVV LKSTTKMSLN ERFTNMLKNK QPMPVNIRAS MQQQQQLASA
60 70 80 90 100
RNRRLAQQME NRPSVQAALK LKQKSLKQRL GKSNIQARLG RPIGALARGA
110 120 130 140 150
IGGRGLPIIQ RGLPRGGLRG GRATRTLLRG GMSLRGQNLL RGGRAVAPRM
160 170 180 190 200
GLRRGGVRGR GGPGRGGLGR GAMGRGGIGG RGRGMIGRGR GGFGGRGRGR
210 220 230 240
GRGRGALTRP VLTKEQLDNQ LDAYMSKTKG HLDAELDAYM AQTDPETND
Length:249
Mass (Da):26,585
Last modified:March 1, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F3E44A53ED0645F
GO
Isoform 2 (identifier: Q9CY57-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.

Note: May be due to an intron retention.
Show »
Length:224
Mass (Da):23,850
Checksum:i6D480418EFCABB24
GO
Isoform 3 (identifier: Q9CY57-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-74: Missing.
     137-182: Missing.

Note: No experimental confirmation available.
Show »
Length:202
Mass (Da):21,978
Checksum:i9D045E5C3055D068
GO
Isoform 4 (identifier: Q9CY57-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.
     137-182: Missing.

Note: No experimental confirmation available.
Show »
Length:178
Mass (Da):19,371
Checksum:i02A7E08E03DD3BF2
GO
Isoform 5 (identifier: Q9CY57-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.
     74-74: Missing.
     137-182: Missing.

Note: No experimental confirmation available.
Show »
Length:177
Mass (Da):19,243
Checksum:iB54CBF9F53701E1F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PW20E9PW20_MOUSE
Chromatin target of PRMT1 protein
Chtop 2500003M10Rik
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YZA1D3YZA1_MOUSE
Chromatin target of PRMT1 protein
Chtop 2500003M10Rik
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z7T7D3Z7T7_MOUSE
Chromatin target of PRMT1 protein
Chtop 2500003M10Rik
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA95102 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB25951 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC37084 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti96L → Q in BAE31263 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0117431 – 25Missing in isoform 2, isoform 4 and isoform 5. 3 PublicationsAdd BLAST25
Alternative sequenceiVSP_01174474Missing in isoform 3 and isoform 5. 1 Publication1
Alternative sequenceiVSP_011745137 – 182Missing in isoform 3, isoform 4 and isoform 5. 2 PublicationsAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB041654 mRNA Translation: BAA95102.1 Different initiation.
AK004558 mRNA Translation: BAB23371.1
AK005377 mRNA Translation: BAB23984.2
AK008885 mRNA Translation: BAB25951.1 Different initiation.
AK010866 mRNA Translation: BAB27232.2
AK047914 mRNA Translation: BAC33189.1
AK077960 mRNA Translation: BAC37084.1 Different initiation.
AK132769 mRNA Translation: BAE21348.1
AK149010 mRNA Translation: BAE28718.1
AK152492 mRNA Translation: BAE31263.1
CH466547 Genomic DNA Translation: EDL15130.1
BC083333 mRNA Translation: AAH83333.1
BC120651 mRNA Translation: AAI20652.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS17532.1 [Q9CY57-2]
CCDS79964.1 [Q9CY57-5]
CCDS79965.1 [Q9CY57-4]
CCDS79966.1 [Q9CY57-3]
CCDS79968.1 [Q9CY57-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001280705.1, NM_001293776.1 [Q9CY57-1]
NP_001280706.1, NM_001293777.1
NP_001280707.1, NM_001293778.1
NP_001280708.1, NM_001293779.1 [Q9CY57-3]
NP_001280710.1, NM_001293781.1 [Q9CY57-5]
NP_001280711.1, NM_001293782.1 [Q9CY57-2]
NP_075704.2, NM_023215.6 [Q9CY57-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000001043; ENSMUSP00000001043; ENSMUSG00000001017 [Q9CY57-2]
ENSMUST00000049937; ENSMUSP00000061800; ENSMUSG00000001017 [Q9CY57-1]
ENSMUST00000076639; ENSMUSP00000075936; ENSMUSG00000001017 [Q9CY57-3]
ENSMUST00000107342; ENSMUSP00000102965; ENSMUSG00000001017 [Q9CY57-5]
ENSMUST00000107343; ENSMUSP00000102966; ENSMUSG00000001017 [Q9CY57-4]
ENSMUST00000107344; ENSMUSP00000102967; ENSMUSG00000001017 [Q9CY57-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
66511

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:66511

UCSC genome browser

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UCSCi
uc008qco.2 mouse [Q9CY57-1]
uc008qcr.2 mouse [Q9CY57-3]
uc056ztp.1 mouse [Q9CY57-5]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041654 mRNA Translation: BAA95102.1 Different initiation.
AK004558 mRNA Translation: BAB23371.1
AK005377 mRNA Translation: BAB23984.2
AK008885 mRNA Translation: BAB25951.1 Different initiation.
AK010866 mRNA Translation: BAB27232.2
AK047914 mRNA Translation: BAC33189.1
AK077960 mRNA Translation: BAC37084.1 Different initiation.
AK132769 mRNA Translation: BAE21348.1
AK149010 mRNA Translation: BAE28718.1
AK152492 mRNA Translation: BAE31263.1
CH466547 Genomic DNA Translation: EDL15130.1
BC083333 mRNA Translation: AAH83333.1
BC120651 mRNA Translation: AAI20652.1
CCDSiCCDS17532.1 [Q9CY57-2]
CCDS79964.1 [Q9CY57-5]
CCDS79965.1 [Q9CY57-4]
CCDS79966.1 [Q9CY57-3]
CCDS79968.1 [Q9CY57-1]
RefSeqiNP_001280705.1, NM_001293776.1 [Q9CY57-1]
NP_001280706.1, NM_001293777.1
NP_001280707.1, NM_001293778.1
NP_001280708.1, NM_001293779.1 [Q9CY57-3]
NP_001280710.1, NM_001293781.1 [Q9CY57-5]
NP_001280711.1, NM_001293782.1 [Q9CY57-2]
NP_075704.2, NM_023215.6 [Q9CY57-2]

3D structure databases

SMRiQ9CY57
ModBaseiSearch...

Protein-protein interaction databases

BioGridi211527, 4 interactors
IntActiQ9CY57, 11 interactors
MINTiQ9CY57
STRINGi10090.ENSMUSP00000001043

PTM databases

iPTMnetiQ9CY57
PhosphoSitePlusiQ9CY57
SwissPalmiQ9CY57

Proteomic databases

PaxDbiQ9CY57
PRIDEiQ9CY57

Genome annotation databases

EnsembliENSMUST00000001043; ENSMUSP00000001043; ENSMUSG00000001017 [Q9CY57-2]
ENSMUST00000049937; ENSMUSP00000061800; ENSMUSG00000001017 [Q9CY57-1]
ENSMUST00000076639; ENSMUSP00000075936; ENSMUSG00000001017 [Q9CY57-3]
ENSMUST00000107342; ENSMUSP00000102965; ENSMUSG00000001017 [Q9CY57-5]
ENSMUST00000107343; ENSMUSP00000102966; ENSMUSG00000001017 [Q9CY57-4]
ENSMUST00000107344; ENSMUSP00000102967; ENSMUSG00000001017 [Q9CY57-2]
GeneIDi66511
KEGGimmu:66511
UCSCiuc008qco.2 mouse [Q9CY57-1]
uc008qcr.2 mouse [Q9CY57-3]
uc056ztp.1 mouse [Q9CY57-5]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26097
MGIiMGI:1913761 Chtop

Phylogenomic databases

eggNOGiENOG410IWUS Eukaryota
ENOG4111XP9 LUCA
GeneTreeiENSGT00390000002869
InParanoidiQ9CY57
OMAiRFTNMMK
OrthoDBi1598721at2759
PhylomeDBiQ9CY57
TreeFamiTF331447

Enzyme and pathway databases

ReactomeiR-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-72187 mRNA 3'-end processing
R-MMU-73856 RNA Polymerase II Transcription Termination

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Chtop mouse

Protein Ontology

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PROi
PR:Q9CY57

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000001017 Expressed in 295 organ(s), highest expression level in saccule of membranous labyrinth
ExpressionAtlasiQ9CY57 baseline and differential
GenevisibleiQ9CY57 MM

Family and domain databases

InterProiView protein in InterPro
IPR025715 FoP_C
PfamiView protein in Pfam
PF13865 FoP_duplication, 1 hit
SMARTiView protein in SMART
SM01218 FoP_duplication, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHTOP_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9CY57
Secondary accession number(s): Q0VBG3
, Q3U7V6, Q3UF43, Q3V105, Q5XJG9, Q8C5N4, Q9D7T3, Q9DB03, Q9DC54, Q9JJ95
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: March 1, 2003
Last modified: October 16, 2019
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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