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Protein

Translocon-associated protein subunit alpha

Gene

Ssr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

Miscellaneous

Seems to bind calcium.By similarity

GO - Biological processi

Keywordsi

LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Translocon-associated protein subunit alpha
Short name:
TRAP-alpha
Alternative name(s):
Signal sequence receptor subunit alpha
Short name:
SSR-alpha
Gene namesi
Name:Ssr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:105082 Ssr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 207LumenalSequence analysisAdd BLAST186
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 286CytoplasmicSequence analysisAdd BLAST58

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003328222 – 286Translocon-associated protein subunit alphaAdd BLAST265

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi136N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei247PhosphoserineBy similarity1
Modified residuei260PhosphothreonineBy similarity1
Modified residuei268PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9CY50
MaxQBiQ9CY50
PaxDbiQ9CY50
PRIDEiQ9CY50
TopDownProteomicsiQ9CY50

PTM databases

iPTMnetiQ9CY50
PhosphoSitePlusiQ9CY50

Expressioni

Gene expression databases

BgeeiENSMUSG00000021427 Expressed in 329 organ(s), highest expression level in urinary bladder
CleanExiMM_SSR1
ExpressionAtlasiQ9CY50 baseline and differential
GenevisibleiQ9CY50 MM

Interactioni

Subunit structurei

Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins (By similarity).By similarity

Protein-protein interaction databases

BioGridi223355, 3 interactors
IntActiQ9CY50, 5 interactors
MINTiQ9CY50
STRINGi10090.ENSMUSP00000021864

Structurei

3D structure databases

ProteinModelPortaliQ9CY50
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.

Sequence similaritiesi

Belongs to the TRAP-alpha family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1631 Eukaryota
ENOG410XNTM LUCA
GeneTreeiENSGT00400000022103
HOGENOMiHOG000006932
HOVERGENiHBG009736
InParanoidiQ9CY50
KOiK13249
OMAiCTFSAPN
OrthoDBiEOG091G0KOC
PhylomeDBiQ9CY50
TreeFamiTF321074

Family and domain databases

InterProiView protein in InterPro
IPR005595 TRAP_alpha
PfamiView protein in Pfam
PF03896 TRAP_alpha, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9CY50-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLLPRLLLL FLLAFPAAVL LRGGPGGSLA LAQDPTEDEE IVEDSIIEDE
60 70 80 90 100
DDEAEVEEDE PTDLAEDKEE EDVSSEPEAS PSADTTILFV KGEDFPANNI
110 120 130 140 150
VKFLVGFTNK GTEDFIVESL DASFRYPQDY QFYIQNFTAL PLNTVVPPQR
160 170 180 190 200
QATFEYSFIP AEPMGGRPFG LVINLNYKDL NGNVFQDAVF NQTVTVIERE
210 220 230 240 250
DGLDGETIFM YMFLAGLGLL VVVGLHQLLE SRKRKRPIQK VEMGTSSQND
260 270 280
VDMSWIPQET LNQINKASPR RQPRKRAQKR SVGSDE
Length:286
Mass (Da):32,065
Last modified:June 1, 2001 - v1
Checksum:i780D1C6880700C8D
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YCT4A0A286YCT4_MOUSE
Translocon-associated protein subun...
Ssr1
298Annotation score:
A0A286YCG8A0A286YCG8_MOUSE
Translocon-associated protein subun...
Ssr1
318Annotation score:
A0A286YDB7A0A286YDB7_MOUSE
Translocon-associated protein subun...
Ssr1
115Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27G → V in AAK16151 (Ref. 1) Curated1
Sequence conflicti27G → V in AAK82421 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF326229 mRNA Translation: AAK16151.2
AF395811 mRNA Translation: AAK82421.1
AK010884 mRNA Translation: BAB27245.1
AK166235 mRNA Translation: BAE38650.1
AK167793 mRNA Translation: BAE39823.1
BC011255 mRNA Translation: AAH11255.1
CCDSiCCDS26459.1
RefSeqiNP_080241.3, NM_025965.3
UniGeneiMm.426670
Mm.490298

Genome annotation databases

EnsembliENSMUST00000021864; ENSMUSP00000021864; ENSMUSG00000021427
GeneIDi107513
KEGGimmu:107513
UCSCiuc011yyk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF326229 mRNA Translation: AAK16151.2
AF395811 mRNA Translation: AAK82421.1
AK010884 mRNA Translation: BAB27245.1
AK166235 mRNA Translation: BAE38650.1
AK167793 mRNA Translation: BAE39823.1
BC011255 mRNA Translation: AAH11255.1
CCDSiCCDS26459.1
RefSeqiNP_080241.3, NM_025965.3
UniGeneiMm.426670
Mm.490298

3D structure databases

ProteinModelPortaliQ9CY50
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi223355, 3 interactors
IntActiQ9CY50, 5 interactors
MINTiQ9CY50
STRINGi10090.ENSMUSP00000021864

PTM databases

iPTMnetiQ9CY50
PhosphoSitePlusiQ9CY50

Proteomic databases

EPDiQ9CY50
MaxQBiQ9CY50
PaxDbiQ9CY50
PRIDEiQ9CY50
TopDownProteomicsiQ9CY50

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021864; ENSMUSP00000021864; ENSMUSG00000021427
GeneIDi107513
KEGGimmu:107513
UCSCiuc011yyk.1 mouse

Organism-specific databases

CTDi6745
MGIiMGI:105082 Ssr1

Phylogenomic databases

eggNOGiKOG1631 Eukaryota
ENOG410XNTM LUCA
GeneTreeiENSGT00400000022103
HOGENOMiHOG000006932
HOVERGENiHBG009736
InParanoidiQ9CY50
KOiK13249
OMAiCTFSAPN
OrthoDBiEOG091G0KOC
PhylomeDBiQ9CY50
TreeFamiTF321074

Miscellaneous databases

ChiTaRSiSsr1 mouse
PROiPR:Q9CY50
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021427 Expressed in 329 organ(s), highest expression level in urinary bladder
CleanExiMM_SSR1
ExpressionAtlasiQ9CY50 baseline and differential
GenevisibleiQ9CY50 MM

Family and domain databases

InterProiView protein in InterPro
IPR005595 TRAP_alpha
PfamiView protein in Pfam
PF03896 TRAP_alpha, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSSRA_MOUSE
AccessioniPrimary (citable) accession number: Q9CY50
Secondary accession number(s): Q3TIM3, Q99MP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2001
Last modified: October 10, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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