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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

Gene

Ndufs4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: MGI

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Alternative name(s):
Complex I-18 kDa
Short name:
CI-18 kDa
Complex I-AQDQ
Short name:
CI-AQDQ
NADH-ubiquinone oxidoreductase 18 kDa subunit
Gene namesi
Name:Ndufs4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1343135 Ndufs4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 42MitochondrionBy similarityAdd BLAST42
ChainiPRO_000002003943 – 175NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialAdd BLAST133

Proteomic databases

EPDiQ9CXZ1
MaxQBiQ9CXZ1
PaxDbiQ9CXZ1
PeptideAtlasiQ9CXZ1
PRIDEiQ9CXZ1

PTM databases

iPTMnetiQ9CXZ1
PhosphoSitePlusiQ9CXZ1

Expressioni

Gene expression databases

CleanExiMM_NDUFS4

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.By similarity

Protein-protein interaction databases

BioGridi201718, 1 interactor
ComplexPortaliCPX-266 Mitochondrial respiratory chain complex I
CORUMiQ9CXZ1
IntActiQ9CXZ1, 4 interactors
MINTiQ9CXZ1
STRINGi10090.ENSMUSP00000022286

Structurei

Secondary structure

1175
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9CXZ1
SMRiQ9CXZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFS4 subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3389 Eukaryota
ENOG4111TR4 LUCA
HOGENOMiHOG000140414
HOVERGENiHBG003007
InParanoidiQ9CXZ1
KOiK03937
PhylomeDBiQ9CXZ1

Family and domain databases

Gene3Di3.30.160.190, 1 hit
InterProiView protein in InterPro
IPR006885 NADH_UbQ_FeS_4_mit
IPR038532 NDUFS4-like_sf
PANTHERiPTHR12219 PTHR12219, 1 hit
PfamiView protein in Pfam
PF04800 ETC_C1_NDUFA4, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9CXZ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVSISVSL RQAMLGRRAM ATAAVSVCRV PSRLLSTSTW KLADNQTRDT
60 70 80 90 100
QLITVDEKLD ITTLTGVPEE HIKTRKVRIF VPARNNMQSG VNNTKKWKME
110 120 130 140 150
FDTRERWENP LMGWASTADP LSNMVLTFSA KEDAIAFAEK NGWSYDVEEK
160 170
KVPKPKSKSY GANFSWNKRT RVSTK
Length:175
Mass (Da):19,785
Last modified:May 10, 2004 - v3
Checksum:i33D565B204D1C7A2
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QPX3E9QPX3_MOUSE
NADH dehydrogenase [ubiquinone] iro...
Ndufs4
175Annotation score:
A0A286YDA8A0A286YDA8_MOUSE
NADH dehydrogenase [ubiquinone] iro...
Ndufs4
37Annotation score:
A0A286YCM7A0A286YCM7_MOUSE
NADH dehydrogenase [ubiquinone] iro...
Ndufs4
35Annotation score:
A0A338P6Q8A0A338P6Q8_MOUSE
NADH dehydrogenase [ubiquinone] iro...
Ndufs4
55Annotation score:
A0A338P7A0A0A338P7A0_MOUSE
NADH dehydrogenase [ubiquinone] iro...
Ndufs4
118Annotation score:

Sequence cautioni

The sequence AAD30474 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68P → Q in BAB27417 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011124 mRNA Translation: BAB27417.2
AF124785 mRNA Translation: AAD30474.1 Different initiation.
CCDSiCCDS49368.1
RefSeqiNP_035017.2, NM_010887.2
UniGeneiMm.253142

Genome annotation databases

GeneIDi17993
KEGGimmu:17993

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011124 mRNA Translation: BAB27417.2
AF124785 mRNA Translation: AAD30474.1 Different initiation.
CCDSiCCDS49368.1
RefSeqiNP_035017.2, NM_010887.2
UniGeneiMm.253142

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6G2Jelectron microscopy3.30Q1-175[»]
6G72electron microscopy3.90Q1-175[»]
ProteinModelPortaliQ9CXZ1
SMRiQ9CXZ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201718, 1 interactor
ComplexPortaliCPX-266 Mitochondrial respiratory chain complex I
CORUMiQ9CXZ1
IntActiQ9CXZ1, 4 interactors
MINTiQ9CXZ1
STRINGi10090.ENSMUSP00000022286

PTM databases

iPTMnetiQ9CXZ1
PhosphoSitePlusiQ9CXZ1

Proteomic databases

EPDiQ9CXZ1
MaxQBiQ9CXZ1
PaxDbiQ9CXZ1
PeptideAtlasiQ9CXZ1
PRIDEiQ9CXZ1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17993
KEGGimmu:17993

Organism-specific databases

CTDi4724
MGIiMGI:1343135 Ndufs4

Phylogenomic databases

eggNOGiKOG3389 Eukaryota
ENOG4111TR4 LUCA
HOGENOMiHOG000140414
HOVERGENiHBG003007
InParanoidiQ9CXZ1
KOiK03937
PhylomeDBiQ9CXZ1

Miscellaneous databases

PROiPR:Q9CXZ1
SOURCEiSearch...

Gene expression databases

CleanExiMM_NDUFS4

Family and domain databases

Gene3Di3.30.160.190, 1 hit
InterProiView protein in InterPro
IPR006885 NADH_UbQ_FeS_4_mit
IPR038532 NDUFS4-like_sf
PANTHERiPTHR12219 PTHR12219, 1 hit
PfamiView protein in Pfam
PF04800 ETC_C1_NDUFA4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNDUS4_MOUSE
AccessioniPrimary (citable) accession number: Q9CXZ1
Secondary accession number(s): Q9WUB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: September 12, 2018
This is version 115 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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