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Protein

Interleukin enhancer-binding factor 2

Gene

Ilf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA (By similarity). Essential for the efficient reshuttling of ILF3 into the nucleus (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin enhancer-binding factor 2
Alternative name(s):
Nuclear factor of activated T-cells 45 kDa
Gene namesi
Name:Ilf2
Synonyms:Nf45
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1915031 Ilf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001260641 – 390Interleukin enhancer-binding factor 2Add BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei16Omega-N-methylarginine; alternateCombined sources1
Modified residuei24Omega-N-methylarginineCombined sources1
Modified residuei52PhosphoserineBy similarity1
Modified residuei68PhosphoserineBy similarity1
Cross-linki186Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki364Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei388PhosphothreonineBy similarity1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CXY6
MaxQBiQ9CXY6
PaxDbiQ9CXY6
PRIDEiQ9CXY6

PTM databases

iPTMnetiQ9CXY6
PhosphoSitePlusiQ9CXY6

Expressioni

Tissue specificityi

Expressed in brain, kidney and ovary; highly expressed in testis, particularly within pachytene cells.1 Publication

Developmental stagei

Expression in testis begins with developmental differentiation of pachytene spermatocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000001016 Expressed in 304 organ(s), highest expression level in pineal body
CleanExiMM_ILF2
GenevisibleiQ9CXY6 MM

Interactioni

Subunit structurei

Forms heterodimers with ILF3. ILF2-ILF3 heterodimers may also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of G22P1/KU70 and XRCC5/KU80. Forms a complex with ILF3, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with IGF2BP1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi212438, 6 interactors
IntActiQ9CXY6, 7 interactors
MINTiQ9CXY6
STRINGi10090.ENSMUSP00000001042

Structurei

Secondary structure

1390
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9CXY6
SMRiQ9CXY6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 371DZFPROSITE-ProRule annotationAdd BLAST348

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi366 – 372Poly-Glu7
Compositional biasi381 – 384Poly-Glu4

Phylogenomic databases

eggNOGiKOG3793 Eukaryota
ENOG410XQCJ LUCA
GeneTreeiENSGT00550000074528
HOGENOMiHOG000067801
HOVERGENiHBG052120
InParanoidiQ9CXY6
KOiK13089
OMAiYEKPPER
OrthoDBiEOG091G0HP1
PhylomeDBiQ9CXY6
TreeFamiTF320194

Family and domain databases

InterProiView protein in InterPro
IPR006116 2-5-oligoadenylate_synth_N
IPR006561 DZF_dom
PfamiView protein in Pfam
PF07528 DZF, 1 hit
SMARTiView protein in SMART
SM00572 DZF, 1 hit
PROSITEiView protein in PROSITE
PS51703 DZF, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CXY6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGDRGRGRG GRFGSRGGPG GGFRPFVPHI PFDFYLCEMA FPRVKPAPDE
60 70 80 90 100
TSFSEALLKR NQDLAPNSAE QASILSLVTK INNVIDNLIV APGTFEVQIE
110 120 130 140 150
EVRQVGSYKK GTMTTGHNVA DLVVILKILP TLEAVAALGN KVVESLRAQD
160 170 180 190 200
PSEVLTMLTN ETGFEISSSD ATVKILITTV PPNLRKLDPE LHLDIKVLQS
210 220 230 240 250
ALAAIRHARW FEENASQSTV KVLIRLLKDL RIRFPGFEPL TPWILDLLGH
260 270 280 290 300
YAVMNNPTRQ PLALNVAYRR CLQILAAGLF LPGSVGITDP CESGNFRVHT
310 320 330 340 350
VMTLEQQDMV CYTAQTLVRI LSHGGFRKIL GQEGDASYLA SEISTWDGVI
360 370 380 390
VTPSEKAYEK PPEKKEGEEE EENTEEPPQG EEEESMETQE
Length:390
Mass (Da):43,062
Last modified:June 1, 2001 - v1
Checksum:i75BAD022DCD4EE01
GO

Sequence cautioni

The sequence BAC27594 differs from that shown. Intron retention.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF458249 Genomic DNA Translation: AAL59388.1
AK013858 mRNA Translation: BAB29021.1
AK031892 mRNA Translation: BAC27594.1 Sequence problems.
AK078003 mRNA Translation: BAC37097.1
AK157129 mRNA Translation: BAE33972.1
BC004033 mRNA Translation: AAH04033.1
BC024718 mRNA Translation: AAH24718.1
CCDSiCCDS17530.1
RefSeqiNP_080650.1, NM_026374.3
UniGeneiMm.227258

Genome annotation databases

EnsembliENSMUST00000001042; ENSMUSP00000001042; ENSMUSG00000001016
GeneIDi67781
KEGGimmu:67781
UCSCiuc008qcj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiILF2_MOUSE
AccessioniPrimary (citable) accession number: Q9CXY6
Secondary accession number(s): Q3U083
, Q5RKG0, Q8CCY9, Q99KS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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