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Entry version 114 (02 Jun 2021)
Sequence version 2 (03 Apr 2007)
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Protein

Endosomal/lysosomal potassium channel TMEM175

Gene

Tmem175

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes (PubMed:26317472, PubMed:33505021).

Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion (PubMed:26317472).

Constitutes the major lysosomal potassium channel (By similarity).

Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors (PubMed:33505021).

The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation (PubMed:33505021).

The lysoK(GF) complex is required to protect neurons against stress-induced damage (PubMed:33505021).

By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Channel activity is activated following interaction with AKT (AKT1, AKT2 or AKT3): interaction promotes activation from closed to an open state. Activation by AKT is independent of AKT serine/threonine-protein kinase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei43Hydrophobic filter residue 1-1By similarity1
Sitei47Hydrophobic filter residue 2-1By similarity1
Sitei50Hydrophobic filter residue 3-1By similarity1
Sitei268Hydrophobic filter residue 1-2By similarity1
Sitei272Hydrophobic filter residue 2-2By similarity1
Sitei275Hydrophobic filter residue 3-2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • potassium channel activity Source: UniProtKB
  • potassium ion leak channel activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Potassium channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endosomal/lysosomal potassium channel TMEM175Curated
Alternative name(s):
Transmembrane protein 1751 Publication
Short name:
mTMEM1751 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tmem1751 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1919642, Tmem175

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 30CytoplasmicBy similarityAdd BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei31 – 53Helical; Name=TM1-1By similarityAdd BLAST23
Topological domaini54 – 74LumenalBy similarityAdd BLAST21
Transmembranei75 – 97Helical; Name=TM2-1By similarityAdd BLAST23
Topological domaini98 – 103CytoplasmicBy similarity6
Transmembranei104 – 125Helical; Name=TM3-1By similarityAdd BLAST22
Topological domaini126 – 135LumenalBy similarity10
Transmembranei136 – 157Helical; Name=TM4-1By similarityAdd BLAST22
Topological domaini158 – 181CytoplasmicBy similarityAdd BLAST24
Transmembranei182 – 202Helical; Name=TM5-1Sequence analysisAdd BLAST21
Topological domaini203 – 207LumenalBy similarity5
Transmembranei208 – 227Helical; Name=TM6-1Sequence analysisAdd BLAST20
Topological domaini228 – 254CytoplasmicBy similarityAdd BLAST27
Transmembranei255 – 279Helical; Name=TM1-2By similarityAdd BLAST25
Topological domaini280 – 306LumenalBy similarityAdd BLAST27
Transmembranei307 – 329Helical; Name=TM2-2By similarityAdd BLAST23
Topological domaini330 – 335CytoplasmicBy similarity6
Transmembranei336 – 357Helical; Name=TM3-2By similarityAdd BLAST22
Topological domaini358 – 372LumenalBy similarityAdd BLAST15
Transmembranei373 – 393Helical; Name=TM4-2By similarityAdd BLAST21
Topological domaini394 – 413CytoplasmicBy similarityAdd BLAST20
Transmembranei414 – 437Helical; Name=TM5-2By similarityAdd BLAST24
Topological domaini438 – 439LumenalBy similarity2
Transmembranei440 – 466Helical; Name=TM6-2By similarityAdd BLAST27
Topological domaini467 – 499CytoplasmicBy similarityAdd BLAST33

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice display accelerated loss of dopaminergic neurons and impaired motor skills (PubMed:33505021). Knockout neurons show increased damage in response to insults and an accumulation of alpha-synuclein (PubMed:33505021). The accumulation of alpha-synuclein leads to increased damage to the integrity of lysosomal membranes (PubMed:33505021).1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi62Q → P: Gain-of-function mutant; increased potassium channel activity in knockin mice. 1 Publication1
Mutagenesisi390I → T: Reduced potassium channel activity in knockin mice. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002825891 – 499Endosomal/lysosomal potassium channel TMEM175Add BLAST499

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei6PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9CXY1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9CXY1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9CXY1

PRoteomics IDEntifications database

More...
PRIDEi
Q9CXY1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
259540

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9CXY1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9CXY1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000013495, Expressed in spermatocyte and 244 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9CXY1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity).

Interacts with AKT (AKT1, AKT2 or AKT3); leading to formation of the lysoK(GF) complex, which activates the channel (PubMed:33505021).

By similarity1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000068607

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9CXY1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 30DisorderedSequence analysisAdd BLAST30
Regioni55 – 60Short helix H1-1By similarity6
Regioni62 – 68Short helix H2-1By similarity7
Regioni285 – 293Short helix H1-2By similarity9
Regioni295 – 301Short helix H2-2By similarity7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi32 – 38RxxxFSD motif 1By similarity7
Motifi257 – 263RxxxFSD motif 2By similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 28Basic and acidic residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Composed of two modules of six transmembranes, forming a homodimer with a tetrameric architecture. The six transmembrane regions of each module are tightly packed within each subunit without undergoing domain swapping. Forms a central ion-conduction pore lined by the side chains of the pore-lining helices. Conserved isoleucine residues (Ile-43 in the first module and Ile-268 in the second module) in the center of the pore serve as the gate in the closed conformation. In the widened channel in the open conformation, the same residues establish a constriction essential for potassium selectivity.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM175 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QR5C, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015667

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_052593_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9CXY1

Identification of Orthologs from Complete Genome Data

More...
OMAi
IVVYAFH

Database of Orthologous Groups

More...
OrthoDBi
894975at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9CXY1

TreeFam database of animal gene trees

More...
TreeFami
TF328838

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010617, TMEM175

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06736, DUF1211, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CXY1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRLQTEEQA VDSEGDSSLH RRNEEGTQSS HRMLGFSDAL LSIIATVMIL
60 70 80 90 100
PVTHTEISPE QQFDKSIQKL LATRIAVYLM TFLIVTVAWT AHTRLFQVVG
110 120 130 140 150
KIDDTLALLN LACMMTITLL PYTFSLMVTF PDVPLGIFLF CVCVIAIGSV
160 170 180 190 200
QAMIVGYAFH FPHLLNPQIQ CSTHRDLSRR HILHLVLRGP ALCFVAAVFS
210 220 230 240 250
LFFFPLSYLL MVTVIFLPHI SKATTWCKDK LMGQRESPAH DMEPFSIDLH
260 270 280 290 300
APLSKERVEA FSDGVYAIVA TLLILDICED NVPDPKDVQE KFSGSLVAAL
310 320 330 340 350
GAYGPQFLAY FGSFATVGLL WFAHHSLFLH VRKATQTMGL LNILSLAFVG
360 370 380 390 400
GLPLAYQQTS AFARQPHDEL ERVRVSCAII FFASIFQFAI WTTALLHQTE
410 420 430 440 450
TLQPAVQFGG QEHAFMFAKL ALYPCASLLA FAATCLLSRF STAIFHLMQI
460 470 480 490
SVPFAFLLLR LLVRLALAGL QVLRGLWPHH PQQDQSEPEA QSQLLPDPC
Length:499
Mass (Da):55,578
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBDED3561EF10EB92
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BHJ8Q8BHJ8_MOUSE
Endosomal/lysosomal potassium chann...
Tmem175
232Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti174H → R in AAH05542 (PubMed:15489334).Curated1
Sequence conflicti197A → S in BAE41678 (PubMed:16141072).Curated1
Sequence conflicti324H → R in BAE41678 (PubMed:16141072).Curated1
Sequence conflicti475G → R in BAB29031 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK013879 mRNA Translation: BAB29031.1
AK170273 mRNA Translation: BAE41678.1
BC005542 mRNA Translation: AAH05542.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS19514.1

NCBI Reference Sequences

More...
RefSeqi
NP_001157004.1, NM_001163532.1
NP_082499.3, NM_028223.3
XP_006535292.1, XM_006535229.2
XP_006535293.1, XM_006535230.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000063272; ENSMUSP00000068607; ENSMUSG00000013495
ENSMUST00000078323; ENSMUSP00000077437; ENSMUSG00000013495
ENSMUST00000120327; ENSMUSP00000112780; ENSMUSG00000013495

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
72392

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:72392

UCSC genome browser

More...
UCSCi
uc008yoq.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013879 mRNA Translation: BAB29031.1
AK170273 mRNA Translation: BAE41678.1
BC005542 mRNA Translation: AAH05542.1
CCDSiCCDS19514.1
RefSeqiNP_001157004.1, NM_001163532.1
NP_082499.3, NM_028223.3
XP_006535292.1, XM_006535229.2
XP_006535293.1, XM_006535230.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068607

PTM databases

iPTMnetiQ9CXY1
PhosphoSitePlusiQ9CXY1

Proteomic databases

EPDiQ9CXY1
MaxQBiQ9CXY1
PaxDbiQ9CXY1
PRIDEiQ9CXY1
ProteomicsDBi259540

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
8167, 59 antibodies

The DNASU plasmid repository

More...
DNASUi
72392

Genome annotation databases

EnsembliENSMUST00000063272; ENSMUSP00000068607; ENSMUSG00000013495
ENSMUST00000078323; ENSMUSP00000077437; ENSMUSG00000013495
ENSMUST00000120327; ENSMUSP00000112780; ENSMUSG00000013495
GeneIDi72392
KEGGimmu:72392
UCSCiuc008yoq.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84286
MGIiMGI:1919642, Tmem175

Phylogenomic databases

eggNOGiENOG502QR5C, Eukaryota
GeneTreeiENSGT00390000015667
HOGENOMiCLU_052593_0_0_1
InParanoidiQ9CXY1
OMAiIVVYAFH
OrthoDBi894975at2759
PhylomeDBiQ9CXY1
TreeFamiTF328838

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
72392, 1 hit in 52 CRISPR screens

Protein Ontology

More...
PROi
PR:Q9CXY1
RNActiQ9CXY1, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000013495, Expressed in spermatocyte and 244 other tissues
GenevisibleiQ9CXY1, MM

Family and domain databases

InterProiView protein in InterPro
IPR010617, TMEM175
PfamiView protein in Pfam
PF06736, DUF1211, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM175_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9CXY1
Secondary accession number(s): Q3TDC4, Q99K00
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: June 2, 2021
This is version 114 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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