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Protein

Hydrolethalus syndrome protein 1 homolog

Gene

Hyls1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in ciliogenesis.By similarity

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Hydrolethalus syndrome protein 1 homolog
Gene namesi
Name:Hyls1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1924082 Hyls1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002849271 – 307Hydrolethalus syndrome protein 1 homologAdd BLAST307

Proteomic databases

PaxDbiQ9CXX0
PRIDEiQ9CXX0

PTM databases

iPTMnetiQ9CXX0
PhosphoSitePlusiQ9CXX0

Expressioni

Tissue specificityi

Expressed in hippocampus and dentate gyrus of 3-month adult brain.1 Publication

Developmental stagei

Detected at each embryonic stage, the highest expression level observed at E11.1 Publication

Gene expression databases

CleanExiMM_HYLS1

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110762

Structurei

3D structure databases

SMRiQ9CXX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HYLS1 family.Curated

Phylogenomic databases

eggNOGiENOG410J0N2 Eukaryota
ENOG4111UPE LUCA
HOGENOMiHOG000112979
HOVERGENiHBG107985
InParanoidiQ9CXX0
KOiK16472
TreeFamiTF336132

Family and domain databases

InterProiView protein in InterPro
IPR026227 HYLS1
IPR027918 HYLS1_C_dom
PfamiView protein in Pfam
PF15311 HYLS1_C, 1 hit
PRINTSiPR02098 HYLETHALUSS1

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CXX0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEKRQAYSV PEAMKQLIGP GGQKWANMDP EERMLAAATA FTRICAGQGE
60 70 80 90 100
GDSRREAQAG QYDPYSKASV TPGKRPALPM HLHFPHTASR VTSSTVSETS
110 120 130 140 150
QKCRKPVMKR KVLRRKPDGE VLVTDESVIS ECESGTESDL GLWDLRHRFM
160 170 180 190 200
NLQFQEGTES PVVTSQKFNL PCEYQGISQE DQLICYLQRE EMDPPVYEQD
210 220 230 240 250
LIVASRPKSF ILPRLDQLSR NRGKIDRVAR YFEYKRDWDS MRFPGEDHRK
260 270 280 290 300
ELRWSVRGQM LSRTEPPSKP QHVYVPNNYL VPLRWGVRCD LANGVMPKKL

PFPLSPS
Length:307
Mass (Da):35,141
Last modified:May 1, 2007 - v2
Checksum:i1F7D5A46BA95B813
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J1K7A0A0R4J1K7_MOUSE
Hydrolethalus syndrome protein 1 ho...
Hyls1 mCG_126066
314Annotation score:

Sequence cautioni

The sequence AAH35953 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB29044 differs from that shown. Reason: Frameshift at position 289.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013896 mRNA Translation: BAB29044.1 Frameshift.
AK131639 mRNA Translation: BAE20733.1
BC035953 mRNA Translation: AAH35953.1 Different initiation.
RefSeqiNP_084038.1, NM_029762.1
UniGeneiMm.482285

Genome annotation databases

GeneIDi76832
KEGGimmu:76832
UCSCiuc009oti.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013896 mRNA Translation: BAB29044.1 Frameshift.
AK131639 mRNA Translation: BAE20733.1
BC035953 mRNA Translation: AAH35953.1 Different initiation.
RefSeqiNP_084038.1, NM_029762.1
UniGeneiMm.482285

3D structure databases

SMRiQ9CXX0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110762

PTM databases

iPTMnetiQ9CXX0
PhosphoSitePlusiQ9CXX0

Proteomic databases

PaxDbiQ9CXX0
PRIDEiQ9CXX0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi76832
KEGGimmu:76832
UCSCiuc009oti.2 mouse

Organism-specific databases

CTDi219844
MGIiMGI:1924082 Hyls1

Phylogenomic databases

eggNOGiENOG410J0N2 Eukaryota
ENOG4111UPE LUCA
HOGENOMiHOG000112979
HOVERGENiHBG107985
InParanoidiQ9CXX0
KOiK16472
TreeFamiTF336132

Miscellaneous databases

PROiPR:Q9CXX0
SOURCEiSearch...

Gene expression databases

CleanExiMM_HYLS1

Family and domain databases

InterProiView protein in InterPro
IPR026227 HYLS1
IPR027918 HYLS1_C_dom
PfamiView protein in Pfam
PF15311 HYLS1_C, 1 hit
PRINTSiPR02098 HYLETHALUSS1
ProtoNetiSearch...

Entry informationi

Entry nameiHYLS1_MOUSE
AccessioniPrimary (citable) accession number: Q9CXX0
Secondary accession number(s): Q3V2R4, Q8CI83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: November 7, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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