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Protein

60S ribosomal protein L11

Gene

Rpl11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:21804542). Promotes nucleolar location of PML (PubMed:15195100).2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Protein family/group databases

MoonProtiQ9CXW4

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L11
Gene namesi
Name:Rpl11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1914275 Rpl11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001250832 – 17860S ribosomal protein L11Add BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Cross-linki38Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei44PhosphothreonineBy similarity1
Modified residuei47PhosphothreonineBy similarity1
Modified residuei52N6-acetyllysine; alternateBy similarity1
Cross-linki52Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei85N6-acetyllysineBy similarity1
Cross-linki154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CXW4
MaxQBiQ9CXW4
PaxDbiQ9CXW4
PeptideAtlasiQ9CXW4
PRIDEiQ9CXW4

PTM databases

iPTMnetiQ9CXW4
PhosphoSitePlusiQ9CXW4
SwissPalmiQ9CXW4

Expressioni

Gene expression databases

BgeeiENSMUSG00000059291
CleanExiMM_RPL11
ExpressionAtlasiQ9CXW4 baseline and differential
GenevisibleiQ9CXW4 MM

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU). Part of a LSU subcomplex, the 5S RNP which is composed of the 5S RNA, RPL5 and RPL11 (By similarity). Interacts with PML (PubMed:15195100). Interacts with MDM2; negatively regulates MDM2-mediated TP53 ubiquitination and degradation (PubMed:15195100, PubMed:21804542). Interacts with NOP53; retains RPL11 into the nucleolus (PubMed:21804542).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Mdm2P238044EBI-1548890,EBI-641788

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211883, 7 interactors
CORUMiQ9CXW4
IntActiQ9CXW4, 6 interactors
MINTiQ9CXW4
STRINGi10090.ENSMUSP00000099595

Structurei

3D structure databases

ProteinModelPortaliQ9CXW4
SMRiQ9CXW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0397 Eukaryota
COG0094 LUCA
GeneTreeiENSGT00910000144211
HOGENOMiHOG000231312
HOVERGENiHBG055214
InParanoidiQ9CXW4
KOiK02868
OMAiEDTMAWF
OrthoDBiEOG091G0LSV
PhylomeDBiQ9CXW4
TreeFamiTF300017

Family and domain databases

Gene3Di3.30.1440.10, 1 hit
InterProiView protein in InterPro
IPR002132 Ribosomal_L5
IPR031309 Ribosomal_L5_C
IPR020929 Ribosomal_L5_CS
IPR022803 Ribosomal_L5_dom_sf
IPR031310 Ribosomal_L5_N
PANTHERiPTHR11994 PTHR11994, 1 hit
PfamiView protein in Pfam
PF00281 Ribosomal_L5, 1 hit
PF00673 Ribosomal_L5_C, 1 hit
PIRSFiPIRSF002161 Ribosomal_L5, 1 hit
SUPFAMiSSF55282 SSF55282, 1 hit
PROSITEiView protein in PROSITE
PS00358 RIBOSOMAL_L5, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CXW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQDQGEKEN PMRELRIRKL CLNICVGESG DRLTRAAKVL EQLTGQTPVF
60 70 80 90 100
SKARYTVRSF GIRRNEKIAV HCTVRGAKAE EILEKGLKVR EYELRKNNFS
110 120 130 140 150
DTGNFGFGIQ EHIDLGIKYD PSIGIYGLDF YVVLGRPGFS IADKKRRTGC
160 170
IGAKHRISKE EAMRWFQQKY DGIILPGK
Length:178
Mass (Da):20,252
Last modified:January 23, 2007 - v4
Checksum:i26EC965C9239774E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48P → Q in BAB29059 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002998 mRNA Translation: BAB22504.1
AK008422 mRNA Translation: BAB25660.1
AK011211 mRNA Translation: BAB27470.1
AK011800 mRNA Translation: BAB27850.1
AK013923 mRNA Translation: BAB29059.1
AK088967 mRNA Translation: BAC40676.1
AK153486 mRNA Translation: BAE32034.1
AK164445 mRNA Translation: BAE37793.1
AK169053 mRNA Translation: BAE40841.1
BC025077 mRNA Translation: AAH25077.1
BC069896 mRNA Translation: AAH69896.1
CCDSiCCDS18799.1
RefSeqiNP_080195.1, NM_025919.2
UniGeneiMm.276856
Mm.371622

Genome annotation databases

EnsembliENSMUST00000102536; ENSMUSP00000099595; ENSMUSG00000059291
GeneIDi67025
KEGGimmu:67025
UCSCiuc008vhr.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRL11_MOUSE
AccessioniPrimary (citable) accession number: Q9CXW4
Secondary accession number(s): Q3TPE3, Q6ZWY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 144 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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