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Protein

Calcyclin-binding protein

Gene

Cacybp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Calcyclin-binding protein
Short name:
CacyBP
Alternative name(s):
Siah-interacting protein
Gene namesi
Name:Cacybp
Synonyms:Sip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1270839 Cacybp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001853902 – 229Calcyclin-binding proteinAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei3PhosphoserineBy similarity1
Modified residuei10N6-acetyllysineBy similarity1
Modified residuei21N6-acetyllysineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei86N6-acetyllysineBy similarity1
Modified residuei119N6-acetyllysineBy similarity1

Post-translational modificationi

Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CXW3
MaxQBiQ9CXW3
PaxDbiQ9CXW3
PeptideAtlasiQ9CXW3
PRIDEiQ9CXW3
TopDownProteomicsiQ9CXW3

2D gel databases

REPRODUCTION-2DPAGEiQ9CXW3

PTM databases

iPTMnetiQ9CXW3
PhosphoSitePlusiQ9CXW3
SwissPalmiQ9CXW3

Expressioni

Tissue specificityi

Highly expressed in brain and EAT cells. Expressed at low level in heart, muscle, and at very low level in the liver, spleen, lung, kidney and stomach.1 Publication

Gene expression databases

BgeeiENSMUSG00000014226 Expressed in 311 organ(s), highest expression level in mandibular prominence
CleanExiMM_CACYBP
ExpressionAtlasiQ9CXW3 baseline and differential
GenevisibleiQ9CXW3 MM

Interactioni

Subunit structurei

Monomer or homodimer. Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1 (By similarity). Interacts with proteins of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a calcium-dependent manner (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198445, 11 interactors
IntActiQ9CXW3, 11 interactors
MINTiQ9CXW3
STRINGi10090.ENSMUSP00000014370

Structurei

Secondary structure

1229
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00226
ProteinModelPortaliQ9CXW3
SMRiQ9CXW3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9CXW3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 168CSPROSITE-ProRule annotationAdd BLAST95
Domaini169 – 229SGSPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 81Interaction with SIAH1By similarityAdd BLAST80
Regioni74 – 229Interaction with SKP1By similarityAdd BLAST156
Regioni155 – 229Interaction with S100A6Add BLAST75

Phylogenomic databases

eggNOGiKOG3260 Eukaryota
ENOG410XSB6 LUCA
GeneTreeiENSGT00390000016470
HOGENOMiHOG000238284
HOVERGENiHBG003242
InParanoidiQ9CXW3
KOiK04507
OMAiWDVLTSI
OrthoDBiEOG091G0LQC
PhylomeDBiQ9CXW3
TreeFamiTF323891

Family and domain databases

CDDicd06468 p23_CacyBP, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR037201 CacyBP_N
IPR037893 CS_CacyBP
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR007699 SGS_dom
IPR015120 Siah-Interact_N
PfamiView protein in Pfam
PF04969 CS, 1 hit
PF05002 SGS, 1 hit
PF09032 Siah-Interact_N, 1 hit
SUPFAMiSSF140106 SSF140106, 1 hit
SSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS51203 CS, 1 hit
PS51048 SGS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CXW3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASVLEELQK DLEEVKVLLE KSTRKRLRDT LTSEKSKIET ELKNKMQQKS
60 70 80 90 100
QKKPELDNEK PAAVVAPLTT GYTVKISNYG WDQSDKFVKI YITLTGVHQV
110 120 130 140 150
PTENVQVHFT ERSFDLLVKN LNGKNYSMIV NNLLKPISVE SSSKKVKTDT
160 170 180 190 200
VIILCRKKAE NTRWDYLTQV EKECKEKEKP SYDTEADPSE GLMNVLKKIY
210 220
EDGDDDMKRT INKAWVESRE KQAREDTEF
Length:229
Mass (Da):26,510
Last modified:June 1, 2001 - v1
Checksum:i2B04B54D0054ACE0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YY29A0A0A6YY29_MOUSE
Calcyclin-binding protein
Cacybp
135Annotation score:

Sequence cautioni

The sequence AAC16757 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97327 mRNA Translation: AAC16757.1 Different initiation.
AK013924 mRNA No translation available.
BC025948 mRNA Translation: AAH25948.1
CCDSiCCDS15406.1
RefSeqiNP_033916.1, NM_009786.2
UniGeneiMm.10702

Genome annotation databases

EnsembliENSMUST00000014370; ENSMUSP00000014370; ENSMUSG00000014226
GeneIDi12301
KEGGimmu:12301
UCSCiuc007deg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97327 mRNA Translation: AAC16757.1 Different initiation.
AK013924 mRNA No translation available.
BC025948 mRNA Translation: AAH25948.1
CCDSiCCDS15406.1
RefSeqiNP_033916.1, NM_009786.2
UniGeneiMm.10702

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YSMNMR-A1-77[»]
2JTTNMR-C/D189-219[»]
DisProtiDP00226
ProteinModelPortaliQ9CXW3
SMRiQ9CXW3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198445, 11 interactors
IntActiQ9CXW3, 11 interactors
MINTiQ9CXW3
STRINGi10090.ENSMUSP00000014370

PTM databases

iPTMnetiQ9CXW3
PhosphoSitePlusiQ9CXW3
SwissPalmiQ9CXW3

2D gel databases

REPRODUCTION-2DPAGEiQ9CXW3

Proteomic databases

EPDiQ9CXW3
MaxQBiQ9CXW3
PaxDbiQ9CXW3
PeptideAtlasiQ9CXW3
PRIDEiQ9CXW3
TopDownProteomicsiQ9CXW3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000014370; ENSMUSP00000014370; ENSMUSG00000014226
GeneIDi12301
KEGGimmu:12301
UCSCiuc007deg.2 mouse

Organism-specific databases

CTDi27101
MGIiMGI:1270839 Cacybp

Phylogenomic databases

eggNOGiKOG3260 Eukaryota
ENOG410XSB6 LUCA
GeneTreeiENSGT00390000016470
HOGENOMiHOG000238284
HOVERGENiHBG003242
InParanoidiQ9CXW3
KOiK04507
OMAiWDVLTSI
OrthoDBiEOG091G0LQC
PhylomeDBiQ9CXW3
TreeFamiTF323891

Miscellaneous databases

EvolutionaryTraceiQ9CXW3
PROiPR:Q9CXW3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000014226 Expressed in 311 organ(s), highest expression level in mandibular prominence
CleanExiMM_CACYBP
ExpressionAtlasiQ9CXW3 baseline and differential
GenevisibleiQ9CXW3 MM

Family and domain databases

CDDicd06468 p23_CacyBP, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR037201 CacyBP_N
IPR037893 CS_CacyBP
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR007699 SGS_dom
IPR015120 Siah-Interact_N
PfamiView protein in Pfam
PF04969 CS, 1 hit
PF05002 SGS, 1 hit
PF09032 Siah-Interact_N, 1 hit
SUPFAMiSSF140106 SSF140106, 1 hit
SSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS51203 CS, 1 hit
PS51048 SGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYBP_MOUSE
AccessioniPrimary (citable) accession number: Q9CXW3
Secondary accession number(s): O70140
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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