Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Gene

Sdhd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in the pathway tricarboxylic acid cycle, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi102Iron (heme axial ligand); shared with SDHCBy similarity1
Binding sitei114Ubiquinone; shared with IP/SDHBBy similarity1

GO - Molecular functioni

  • heme binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • succinate dehydrogenase activity Source: MGI
  • ubiquinone binding Source: UniProtKB

GO - Biological processi

  • cellular response to hypoxia Source: MGI
  • mitochondrial electron transport, succinate to ubiquinone Source: GO_Central
  • regulation of catecholamine secretion Source: MGI
  • tricarboxylic acid cycle Source: MGI

Keywordsi

Biological processElectron transport, Transport, Tricarboxylic acid cycle
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-71403 Citric acid cycle (TCA cycle)
UniPathwayiUPA00223

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
Short name:
CybS
Alternative name(s):
CII-4
QPs3
Succinate dehydrogenase complex subunit D
Succinate-ubiquinone oxidoreductase cytochrome b small subunit
Succinate-ubiquinone reductase membrane anchor subunit
Gene namesi
Name:Sdhd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1914175 Sdhd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini57 – 63Mitochondrial matrixBy similarity7
Transmembranei64 – 85HelicalBy similarityAdd BLAST22
Topological domaini86 – 90Mitochondrial intermembraneBy similarity5
Transmembranei91 – 111HelicalBy similarityAdd BLAST21
Topological domaini112 – 120Mitochondrial matrixBy similarity9
Transmembranei121 – 142HelicalBy similarityAdd BLAST22
Topological domaini143 – 159Mitochondrial intermembraneBy similarityAdd BLAST17

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 56MitochondrionSequence analysisAdd BLAST56
ChainiPRO_000000648857 – 159Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialAdd BLAST103

Proteomic databases

MaxQBiQ9CXV1
PaxDbiQ9CXV1
PeptideAtlasiQ9CXV1
PRIDEiQ9CXV1
TopDownProteomicsiQ9CXV1

PTM databases

SwissPalmiQ9CXV1

Expressioni

Gene expression databases

BgeeiENSMUSG00000000171
GenevisibleiQ9CXV1 MM

Interactioni

Subunit structurei

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.By similarity

Protein-protein interaction databases

ComplexPortaliCPX-562 Mitochondrial respiratory chain complex II
CORUMiQ9CXV1
STRINGi10090.ENSMUSP00000000175

Structurei

3D structure databases

ProteinModelPortaliQ9CXV1
SMRiQ9CXV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CybS family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4097 Eukaryota
ENOG4111RTW LUCA
GeneTreeiENSGT00390000010003
HOGENOMiHOG000290645
HOVERGENiHBG003003
InParanoidiQ9CXV1
KOiK00237
OMAiPCSAVDY
OrthoDBiEOG091G0RHX
PhylomeDBiQ9CXV1
TreeFamiTF313310

Family and domain databases

CDDicd03496 SQR_TypeC_CybS, 1 hit
Gene3Di1.20.1300.10, 1 hit
InterProiView protein in InterPro
IPR007992 CybS
IPR034804 SQR/QFR_C/D
PANTHERiPTHR13337 PTHR13337, 1 hit
SUPFAMiSSF81343 SSF81343, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CXV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLLKLGVL CSGQGARALL LRSRVVRPAY VSAFLQDQPT QGRCGTQHIH
60 70 80 90 100
LSPSHHSGSK AASLHWTSER VVSVLLLGLI PAGYLNPCSV VDYSLAAALT
110 120 130 140 150
LHSHWGLGQV VTDYVHGDTL PKAARAGLLA LSALTFAGLC YFNYHDVGIC

RAVAMLWKL
Length:159
Mass (Da):17,014
Last modified:March 1, 2003 - v2
Checksum:iCB3B3CB37E257A06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013962 mRNA Translation: BAB29086.2
AK135970 mRNA Translation: BAE22752.1
BC145731 mRNA Translation: AAI45732.1
BC145733 mRNA Translation: AAI45734.1
CCDSiCCDS40623.1
RefSeqiNP_080124.1, NM_025848.3
UniGeneiMm.10406

Genome annotation databases

EnsembliENSMUST00000000175; ENSMUSP00000000175; ENSMUSG00000000171
GeneIDi66925
KEGGimmu:66925
UCSCiuc009pjv.2 mouse

Similar proteinsi

Entry informationi

Entry nameiDHSD_MOUSE
AccessioniPrimary (citable) accession number: Q9CXV1
Secondary accession number(s): A6H629, Q3UX11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2003
Last modified: June 20, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health