UniProtKB - Q9CXU1 (MED31_MOUSE)
Mediator of RNA polymerase II transcription subunit 31
Med31
Functioni
GO - Molecular functioni
- transcription coregulator activity Source: InterPro
- ubiquitin protein ligase activity Source: Ensembl
GO - Biological processi
- limb development Source: MGI
- negative regulation of fibroblast proliferation Source: MGI
- protein ubiquitination Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Mediator of RNA polymerase II transcription subunit 31Alternative name(s): Mediator complex subunit 31 Mediator complex subunit SOH1 |
Gene namesi | Name:Med31 Synonyms:Soh1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1914529, Med31 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- core mediator complex Source: GO_Central
- mediator complex Source: MGI
- nucleoplasm Source: Reactome
Other locations
- ubiquitin ligase complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000212528 | 2 – 131 | Mediator of RNA polymerase II transcription subunit 31Add BLAST | 130 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9CXU1 |
MaxQBi | Q9CXU1 |
PaxDbi | Q9CXU1 |
PeptideAtlasi | Q9CXU1 |
PRIDEi | Q9CXU1 |
PTM databases
iPTMneti | Q9CXU1 |
PhosphoSitePlusi | Q9CXU1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000020801, Expressed in testis and 277 other tissues |
Genevisiblei | Q9CXU1, MM |
Interactioni
Subunit structurei
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).
By similarityBinary interactionsi
Q9CXU1
With | #Exp. | IntAct |
---|---|---|
Med19 [Q8C1S0] | 2 | EBI-309355,EBI-398761 |
Protein-protein interaction databases
BioGRIDi | 212068, 2 interactors |
ComplexPortali | CPX-3264, Core mediator complex |
IntActi | Q9CXU1, 8 interactors |
MINTi | Q9CXU1 |
STRINGi | 10090.ENSMUSP00000021157 |
Miscellaneous databases
RNActi | Q9CXU1, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 122 – 125 | Poly-Gln | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4086, Eukaryota |
GeneTreei | ENSGT00390000015531 |
HOGENOMi | CLU_071681_5_1_1 |
InParanoidi | Q9CXU1 |
OMAi | QILLWQH |
OrthoDBi | 1480492at2759 |
PhylomeDBi | Q9CXU1 |
TreeFami | TF105799 |
Family and domain databases
Gene3Di | 1.10.10.1340, 1 hit |
InterProi | View protein in InterPro IPR038089, Med31_sf IPR008831, Mediator_Med31 |
PANTHERi | PTHR13186, PTHR13186, 1 hit |
Pfami | View protein in Pfam PF05669, Med31, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MAAAVAMETD DAGNRLRFQL ELEFVQCLAN PNYLNFLAQR GYFKDKAFVN
60 70 80 90 100
YLKYLLYWKE PEYAKYLKYP QCLHMLELLQ YEHFRKELVN AQCAKFIDEQ
110 120 130
QILHWQHYSR KRVRLQQALA EQQQQNNTAG K
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 86 | K → E in BAB29102 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK005655 mRNA Translation: BAB24169.1 AK013990 mRNA Translation: BAB29102.1 BX119911 Genomic DNA No translation available. BC019685 mRNA Translation: AAH19685.1 BC051929 mRNA Translation: AAH51929.1 |
CCDSi | CCDS24981.1 |
RefSeqi | NP_080344.2, NM_026068.2 |
Genome annotation databases
Ensembli | ENSMUST00000021157; ENSMUSP00000021157; ENSMUSG00000020801 |
GeneIDi | 67279 |
KEGGi | mmu:67279 |
UCSCi | uc007jyk.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK005655 mRNA Translation: BAB24169.1 AK013990 mRNA Translation: BAB29102.1 BX119911 Genomic DNA No translation available. BC019685 mRNA Translation: AAH19685.1 BC051929 mRNA Translation: AAH51929.1 |
CCDSi | CCDS24981.1 |
RefSeqi | NP_080344.2, NM_026068.2 |
3D structure databases
SMRi | Q9CXU1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 212068, 2 interactors |
ComplexPortali | CPX-3264, Core mediator complex |
IntActi | Q9CXU1, 8 interactors |
MINTi | Q9CXU1 |
STRINGi | 10090.ENSMUSP00000021157 |
PTM databases
iPTMneti | Q9CXU1 |
PhosphoSitePlusi | Q9CXU1 |
Proteomic databases
EPDi | Q9CXU1 |
MaxQBi | Q9CXU1 |
PaxDbi | Q9CXU1 |
PeptideAtlasi | Q9CXU1 |
PRIDEi | Q9CXU1 |
Protocols and materials databases
Antibodypediai | 23820, 104 antibodies |
DNASUi | 67279 |
Genome annotation databases
Ensembli | ENSMUST00000021157; ENSMUSP00000021157; ENSMUSG00000020801 |
GeneIDi | 67279 |
KEGGi | mmu:67279 |
UCSCi | uc007jyk.1, mouse |
Organism-specific databases
CTDi | 51003 |
MGIi | MGI:1914529, Med31 |
Phylogenomic databases
eggNOGi | KOG4086, Eukaryota |
GeneTreei | ENSGT00390000015531 |
HOGENOMi | CLU_071681_5_1_1 |
InParanoidi | Q9CXU1 |
OMAi | QILLWQH |
OrthoDBi | 1480492at2759 |
PhylomeDBi | Q9CXU1 |
TreeFami | TF105799 |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 67279, 7 hits in 18 CRISPR screens |
ChiTaRSi | Med31, mouse |
PROi | PR:Q9CXU1 |
RNActi | Q9CXU1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020801, Expressed in testis and 277 other tissues |
Genevisiblei | Q9CXU1, MM |
Family and domain databases
Gene3Di | 1.10.10.1340, 1 hit |
InterProi | View protein in InterPro IPR038089, Med31_sf IPR008831, Mediator_Med31 |
PANTHERi | PTHR13186, PTHR13186, 1 hit |
Pfami | View protein in Pfam PF05669, Med31, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MED31_MOUSE | |
Accessioni | Q9CXU1Primary (citable) accession number: Q9CXU1 Secondary accession number(s): Q9DAP5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2003 |
Last sequence update: | October 31, 2003 | |
Last modified: | February 10, 2021 | |
This is version 139 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families