UniProtKB - Q9CXU0 (MED10_MOUSE)
Mediator of RNA polymerase II transcription subunit 10
Med10
Functioni
GO - Molecular functioni
- transcription coregulator activity Source: GO_Central
- ubiquitin protein ligase activity Source: Ensembl
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: MGI
- protein ubiquitination Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- stem cell population maintenance Source: MGI
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Mediator of RNA polymerase II transcription subunit 10Alternative name(s): Mediator complex subunit 10 |
Gene namesi | Name:Med10 Synonyms:D13Wsu50e |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:106331, Med10 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- mediator complex Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: GO_Central
Other locations
- ubiquitin ligase complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000303153 | 1 – 135 | Mediator of RNA polymerase II transcription subunit 10Add BLAST | 135 |
Proteomic databases
EPDi | Q9CXU0 |
MaxQBi | Q9CXU0 |
PaxDbi | Q9CXU0 |
PeptideAtlasi | Q9CXU0 |
PRIDEi | Q9CXU0 |
PTM databases
iPTMneti | Q9CXU0 |
PhosphoSitePlusi | Q9CXU0 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000021598, Expressed in secondary oocyte and 300 other tissues |
Genevisiblei | Q9CXU0, MM |
Interactioni
Subunit structurei
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 205750, 1 interactor |
ComplexPortali | CPX-3264, Core mediator complex |
IntActi | Q9CXU0, 2 interactors |
STRINGi | 10090.ENSMUSP00000022089 |
Miscellaneous databases
RNActi | Q9CXU0, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3046, Eukaryota |
GeneTreei | ENSGT00390000014501 |
HOGENOMi | CLU_096169_3_0_1 |
InParanoidi | Q9CXU0 |
OMAi | GKIDTMT |
OrthoDBi | 1403581at2759 |
PhylomeDBi | Q9CXU0 |
TreeFami | TF315096 |
Family and domain databases
InterProi | View protein in InterPro IPR019145, Mediator_Med10 |
Pfami | View protein in Pfam PF09748, Med10, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAEKFDHLEE HLEKFVENIR QLGIIVSDFQ PSSQAGLSQK LNFIVTGLQD
60 70 80 90 100
IDKCRQQLHD ITVPLEVFEY IDQGRNPQLY TKECLERALA KNEQVKGKID
110 120 130
TMKKFKSLLI QELSKVFPED MAKYRSIRGE DHPPS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1Y7VMY2 | A0A1Y7VMY2_MOUSE | Mediator of RNA polymerase II trans... | Med10 MED10 | 154 | Annotation score: | ||
A0A1Y7VKC0 | A0A1Y7VKC0_MOUSE | Mediator of RNA polymerase II trans... | Med10 MED10 | 83 | Annotation score: | ||
A0A1Y7VKE4 | A0A1Y7VKE4_MOUSE | Mediator of RNA polymerase II trans... | Med10 MED10 | 100 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 130 | E → G in BAE33733 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK013992 mRNA Translation: BAB29103.1 AK156498 mRNA Translation: BAE33733.1 BC048638 mRNA Translation: AAH48638.2 BC056438 mRNA Translation: AAH56438.1 |
CCDSi | CCDS26625.1 |
RefSeqi | NP_613062.1, NM_138596.2 |
Genome annotation databases
Ensembli | ENSMUST00000022089; ENSMUSP00000022089; ENSMUSG00000021598 |
GeneIDi | 28077 |
UCSCi | uc007rcq.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK013992 mRNA Translation: BAB29103.1 AK156498 mRNA Translation: BAE33733.1 BC048638 mRNA Translation: AAH48638.2 BC056438 mRNA Translation: AAH56438.1 |
CCDSi | CCDS26625.1 |
RefSeqi | NP_613062.1, NM_138596.2 |
3D structure databases
SMRi | Q9CXU0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 205750, 1 interactor |
ComplexPortali | CPX-3264, Core mediator complex |
IntActi | Q9CXU0, 2 interactors |
STRINGi | 10090.ENSMUSP00000022089 |
PTM databases
iPTMneti | Q9CXU0 |
PhosphoSitePlusi | Q9CXU0 |
Proteomic databases
EPDi | Q9CXU0 |
MaxQBi | Q9CXU0 |
PaxDbi | Q9CXU0 |
PeptideAtlasi | Q9CXU0 |
PRIDEi | Q9CXU0 |
Protocols and materials databases
Antibodypediai | 43141, 31 antibodies |
DNASUi | 28077 |
Genome annotation databases
Ensembli | ENSMUST00000022089; ENSMUSP00000022089; ENSMUSG00000021598 |
GeneIDi | 28077 |
UCSCi | uc007rcq.1, mouse |
Organism-specific databases
CTDi | 84246 |
MGIi | MGI:106331, Med10 |
Phylogenomic databases
eggNOGi | KOG3046, Eukaryota |
GeneTreei | ENSGT00390000014501 |
HOGENOMi | CLU_096169_3_0_1 |
InParanoidi | Q9CXU0 |
OMAi | GKIDTMT |
OrthoDBi | 1403581at2759 |
PhylomeDBi | Q9CXU0 |
TreeFami | TF315096 |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 28077, 8 hits in 16 CRISPR screens |
ChiTaRSi | Med10, mouse |
PROi | PR:Q9CXU0 |
RNActi | Q9CXU0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021598, Expressed in secondary oocyte and 300 other tissues |
Genevisiblei | Q9CXU0, MM |
Family and domain databases
InterProi | View protein in InterPro IPR019145, Mediator_Med10 |
Pfami | View protein in Pfam PF09748, Med10, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MED10_MOUSE | |
Accessioni | Q9CXU0Primary (citable) accession number: Q9CXU0 Secondary accession number(s): Q3U0W8, Q80VV0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | June 1, 2001 | |
Last modified: | October 7, 2020 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families